PhD student at National University of Singapore
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![Figure 3. Phosphorylated tau CSF epitopes and Ab PET associations. T-parametric maps show the voxel-wise association between CSF biomarkers and [18F]AZD4694 in all participants (e) as well as within CI (f) and CU (g). Models were adjusted by age and sex and RFT was used to account for multiple comparisons (significant t-values > 3.1). The dot plot (h) shows the average slope (beta) values by ROI for each of the CSF biomarkers. The beta value was derived from linear models that had Ab PET as the outcome measure, the CSF biomarkers were the predictors and the covariates were sex and age. These models were performed at the voxel level and the CSF p-tau beta values of each voxel were averaged within ROIs. Were](https://pbs.twimg.com/media/FLd0D04XEAEpJoE.jpg?name=orig)
ALT Figure 3. Phosphorylated tau CSF epitopes and Ab PET associations. T-parametric maps show the voxel-wise association between CSF biomarkers and [18F]AZD4694 in all participants (e) as well as within CI (f) and CU (g). Models were adjusted by age and sex and RFT was used to account for multiple comparisons (significant t-values > 3.1). The dot plot (h) shows the average slope (beta) values by ROI for each of the CSF biomarkers. The beta value was derived from linear models that had Ab PET as the outcome measure, the CSF biomarkers were the predictors and the covariates were sex and age. These models were performed at the voxel level and the CSF p-tau beta values of each voxel were averaged within ROIs. Were
ALT Figure 4. P-tau231 as an early biomarker of Ab pathology. The theoretical framework proposed presents a temporarily ordered progression of CSF p-tau epitopes in the context of the AD continuum, in which we hypothesize CSF p-tau231 as the first biomarker to become altered in the pre-amyloid phase, being then followed by p-tau217 and p-tau181 at pre-clinical and clinical stages.
![Phosphorylated tau CSF epitopes and Tau PET associations. Spearman rank correlations between CSF biomarkers and tau PET ([18F]MK6240) across all groups show p-tau231 as having the highest correlation coefficient, followed by p-tau217 (ac). The accuracy of CSF biomarkers in distinguishing tau PET status (positive vs negative) is evidenced by AUCs as shown in (d). T-parametric maps show the voxel-wise association between CSF biomarkers and [18F]MK6240 in all participants (e) as well as within CI (f) and CU (g). Models were adjusted for age and sex and RFT was used to account for multiple comparisons (significant t-values > 3.1). CU: cognitively unimpaired; CI: cognitively impaired.](https://pbs.twimg.com/media/FLd0MCZXwAEIY3t.jpg?name=orig)
ALT Phosphorylated tau CSF epitopes and Tau PET associations. Spearman rank correlations between CSF biomarkers and tau PET ([18F]MK6240) across all groups show p-tau231 as having the highest correlation coefficient, followed by p-tau217 (ac). The accuracy of CSF biomarkers in distinguishing tau PET status (positive vs negative) is evidenced by AUCs as shown in (d). T-parametric maps show the voxel-wise association between CSF biomarkers and [18F]MK6240 in all participants (e) as well as within CI (f) and CU (g). Models were adjusted for age and sex and RFT was used to account for multiple comparisons (significant t-values > 3.1). CU: cognitively unimpaired; CI: cognitively impaired.
