The Mostoslavsky lab at Harvard & Mass General Cancer Center. We study chromatin, cancer, metabolism, DNA repair, PTMs et al. Tweets are from anyone in the lab!
Boston, MA, USA
Joined April 2018
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Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to @ThomasLClarke for leading the project!
nature.com/articles/s41556-0…
that inhibits CD8 T cells, enhancing tumor growth. The study places neutrophils at the heart of a metabolically driven immunosuppressive network, one of the first examples of a metabolite functioning as an non-genetic alteration shaping the immune milieu and tumor evolution
in turn increasing lactate production, and lactylation of the fumarate hydratase enzyme. This event drives release of fumarate that is taken up by neutrophils, where it drives inhibition of the chromatin enzyme KDM2B (an aKG-dependent dioxygenase), and a transcriptional switch
Happy to share our news&views of a recent paper by He and colleagues, describing a new metabolic-epigenetic pathway that drives immune suppression in colorectal cancer. It involves a unique adaptation by which increase in GSK3b in tumor cells drives expression of glycolytic genes
Mostoslavsky Lab retweeted
Thanks @HarvardGSAS for featuring my story going beyond the dogmas of life. Cannot wait to formally share with the world all the cool science we’re doing at the @MostoslavskyLab @MGHCancerCenter.
gsas.harvard.edu/news/beyond…
Mostoslavsky Lab retweeted
We’re happy to share our new study out today @NatureCellBio
We show that a chromatin factor, ZNF280A, is required for DNA double strand break repair, linking its absence to clinical features in 22q11.2 distal deletion syndrome.
@MostoslavskyLab
nature.com/articles/s41556-0…
Mostoslavsky Lab retweeted
Excited to share our new work on how DNAJB1-PRKACA drives cancer cell growth in Fibrolamellar Carcinoma.
@CD_AACR Thanks to all our collaborators and funding support. @FibroFoundation @AICF_nyc @DonaBertarelli @ForbeckForums @AlexLemonade
Now online in @CD_AACR: DNAJB1-PRKACA Drives #Fibrolamellar Liver Cancer via Impaired SIK Signaling & CRTC2/p300-mediated Transcriptional Reprogramming - by @IlariaG32, @DoransRing6012, Taranjit Gujral, Nabeel Bardeesy, et al. doi.org/10.1158/2159-8290.CD… @fredhutch @MGHCancerCenter
Mostoslavsky Lab retweeted
New Research: Subcellular one carbon metabolism in cancer, aging and epigenetics frontiersin.org/articles/10.… #FrontiersIn #Epigenetics #Epigenomics
Really happy to share our new mini Review on One Carbon Metabolism and chromatin (fantastic job by @Tiz_bernasocchi. Out in @FrontGenetics frontiersin.org/journals/epi…
Mostoslavsky Lab retweeted
New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/scie…
#CancerResearch #Cholangiocarcinoma #IDH1 1/n
The Mostoslavsky Lab is looking for a highly motivated Research Technician interested in being part of our team for at least two years! Please share with your networks, and/or apply by sending an intro email with CV to: [email protected]
This will be a full-time research technician position, roles will include assisting with basic science techniques, from standard molecular biology to advanced biochemistry, genetics, and in vivo work.
Mostoslavsky Lab retweeted
FOR THE LOVE OF PURINES: We are truly excited to share our latest work @CellPressNews on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors.cell.com/cell/fulltext/S0092…
Thrilled to be a Keynote Speaker at the Center of Excellence in Chromosome Biology (CECB) Symposium in @theNCI. Thanks @WeyemiLab and @LabShalini for the honor!
Mostoslavsky Lab retweeted
Massive effort by Christina Ferrer @MostoslavskyLab! I am so happy to see this piece of work finally published!
Online now!! Really thrilled to share our latest work identifying a novel driver of metastasis, Gstt1, @NatureCellBio. A huge effort lead by Christina Ferrer and an incredible team of collaborators!!
link.springer.com/article/10…
Online now!! Really thrilled to share our latest work identifying a novel driver of metastasis, Gstt1, @NatureCellBio. A huge effort lead by Christina Ferrer and an incredible team of collaborators!!
link.springer.com/article/10…
Gstt1, a glutathione conjugase, normally expressed only in the liver, it is specifically upregulated in metastatic cells. Critically, inhibition of Gstt1 does not impact primary tumors, but completely eliminated metastatic growth.
Link to pdf rdcu.be/dKtEA