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OpenCellCZB (@OpenCellCZB) profile picture

OpenCellCZB

@OpenCellCZB

OpenCell is a collaborative proteome-scale project to measure human protein localizations and interactions led by the @LeonettiManuel lab @czbiohub

 San Francisco, CA
opencell.czbiohub.org
Joined March 2021
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  • Followers191
One of the super useful features of the opencell.czbiohub.org website is that you can look up the cellular copy numbers and concentrations of your favorite proteins - check it out! (even for proteins that aren't among our targets or their interactors)
Image from Marco Hein @marcoyannic.bsky.social (@marcoyannic)
Manuel Leonetti (@LeonettiManuel) profile pictureManuel Leonetti@LeonettiManuel11 Mar 2022
Our paper is out today in @ScienceMagazine, I’m stoked @OpenCellCZB ! Check out opencell.czbiohub.org: CRISPR tagging + 3D live imaging + IP mass spec to map the human proteome. science.org/doi/10.1126/scie… 👇 tweetorial from our 2021 pre-print.
Image from Manuel Leonetti (@LeonettiManuel)
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OpenCellCZB retweeted
elevyLab (@ElevyLab) profile picture
elevyLab@ElevyLab15 Mar 2022
Check our perspective on the @OpenCellCZB awesome work from @LeonettiManuel "Modules" help interpret biological systems. However, we see in these new data that connectors far outweigh modules in PPI networks! What does that mean? We discuss it: science.org/doi/10.1126/scie…
Image from elevyLab (@ElevyLab)
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Our paper is out today in @ScienceMagazine, I’m stoked @OpenCellCZB ! Check out opencell.czbiohub.org: CRISPR tagging + 3D live imaging + IP mass spec to map the human proteome. science.org/doi/10.1126/scie… 👇 tweetorial from our 2021 pre-print.
Image from Manuel Leonetti (@LeonettiManuel)
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Published today in Science, a team from CZ Biohub and @MPI_Biochem combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. 🧵 science.org/doi/10.1126/scie…
OpenCell: Endogenous tagging for the cartography of human cellular organization

OpenCell: Endogenous tagging for the cartography of human cellular organization

Combining genome engineering, live-cell imaging, mass spectrometry, and data science are used to map the localization and interactions of human proteins.

science.org
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.#OpenCell from @czbiohub -- results from which are published in @ScienceMagazine today -- is mapping cells one protein at a time, paving a new way to visualize cellular architecture. science.org/doi/full/10.1126…. Video: youtube.com/watch?v=6j4fpV-q…
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Cellular life is amazingly complex. To find cures for diseases, we must understand the molecular details of how cells and their proteins operate. Visit our new OpenCell website and interactively explore the localization and interactions of human proteins:opencell.czbiohub.org
Manuel Leonetti (@LeonettiManuel) profile pictureManuel Leonetti@LeonettiManuel30 Mar 2021
Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
Image from Manuel Leonetti (@LeonettiManuel)
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OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization biorxiv.org/cgi/content/shor… #bioRxiv
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Self-Supervised Deep-Learning Encodes High-Resolution Features of Protein Subcellular Localization biorxiv.org/cgi/content/shor… #bioRxiv
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