Dr. Pam R (@PamR33) header
Dr. Pam R (@PamR33) profile picture

Dr. Pam R

@PamR33

Dreamer by day, scientist by night at the Red-Horse Lab @Stanford 🤍🔬 | Prev. @GladstoneInst @Cal

Joined October 2011
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"Among all the uncertainty, you can always count on awesome science to make you smile. Check out our latest @CellCellPress interdisciplinary endeavor—a reminder that we all have a 🫀, whether right-dominant or not! sciencedirect.com/science/ar…
Image from Dr. Pam R (@PamR33)
Image from Dr. Pam R (@PamR33)
Image from Dr. Pam R (@PamR33)
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🔬The Hall Lab at the Stowers Institute is looking for a Research Technician II to join the team! Led by Stowers Fellow Nelson Hall, Ph.D., the lab explores how stem cells support regeneration across diverse species, including some fascinating flatworms. 🪱 Interested in contributing to innovative research and exploring new approaches to understanding regeneration? 🎥 Meet Nelson and learn more about his research! 🔗 Explore the opportunity and apply: bit.ly/4jFzHyJ #STEMJobs #Hiring #ResearchJobs
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Dr. Pam R retweeted
Ali Max Erturk (@erturklab) profile picture
Ali Max Erturk
@erturklabOct 13
We recently introduced DISCO-seq 🤩: scRNA-seq after tissue clearing 🧬 biorxiv.org/content/10.64898… First, image whole organs or bodies in 3D at cellular resolution. Then select regions for unbiased scRNA-seq. From glioblastoma to whole-body SARS-CoV-2 spike mapping 👇🏻 #DISCOseq
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Researchers in @ScienceAdvances have developed a cross-national “speech clock” that can track biological aging and markers of dementia across a large and diverse sample of Latin American populations. scim.ag/47rTx99
Image from Science Magazine (@ScienceMagazine)
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Learn about the heart's ‘little brain’ and how it protects us against stress 🧠🫀- from my second hang out spot, Ruiz Chang's lab. Study led by newly minted Dr. Qian Xu 🎉 cell.com/cell/fulltext/S0092…
The intrinsic cardiac nervous system is essential for cardiac function and survival

The intrinsic cardiac nervous system is essential for cardiac function and survival

Two genetically distinct neuronal subtypes in the intrinsic cardiac nervous system are differentially required for baseline cardiac function and stress resilience to maintain cardiac stability and...

cell.com
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A mouse that lives higher than any other mammal has evolved unexpected adaptations that allow it to thrive from sea level to Andean summits, researchers report in a new Science study. According to the findings, the Andean leaf-eared mouse uses a distinct combination of metabolic and genetic adaptations—including an unexpected ability to detoxify poisonous plants—to survive extreme environments. Learn more: scim.ag/3RwD4My
Image from Science Magazine (@ScienceMagazine)
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I am a fan of @ifanirene work. This is an incredible study, featuring one of the most iconic Peruvian (and Andean) animals, the Cuy (guinea pig). Congratulations!
Irene Xiaochen Fan (@ifanirene) profile pictureIrene Xiaochen Fan@ifanireneMay 12
Why do guinea pigs have so many natural bypass arteries? In our preprint, we use this ischemia-resistant mammal + in vivo Perturb-seq to ask how protective collateral arteries are built. The surprise: more collaterals may come from turning down “artery repressor” pathways, including WNT, hypoxia-response, and TCA cycle. Knocking down selected repressors increased pial collaterals in mouse brain. @RonghaoZhou @kristyredhorse @jengreitz @BRaftrey @PamR33 @ChenMaggieSY biorxiv.org/content/10.64898…
Image from Irene Xiaochen Fan (@ifanirene)
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Latin American genomics is on fire! 🔥. Now is the genetic diversity of South American genomes in the cover of @Nature! Great work by @MacsCastro and @hunemeier_t's research team! Congrats!👏 nature.com/nature/volumes/65…
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Outstanding work from an outstanding grad student @jameszsci
James Zwierzynski (@jameszsci) profile pictureJames Zwierzynski@jameszsciApr 10
Excited to share our preprint, reviving @kristyredhorse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:
Image from James Zwierzynski (@jameszsci)
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ARTEMIS II AS SEEN BY THE OFFICIAL NASA CESSNA THIS IS THE BEST LAUNCH VIDEO AND IT ISN'T CLOSE
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Dr. Pam R retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopolMar 25
The AI Scientist, a new @Nature article making the case: "The dawn of a new era in which the process of discovery is no longer a solely human pursuit and in which the pace at which we are able to reap the harvest of scientific discovery could accelerate dramatically." nature.com/articles/s41586-0…
Towards end-to-end automation of AI research

Towards end-to-end automation of AI research

Nature - An artificial intelligence system can produce research papers with minimal human involvement, even passing the first round of peer review for the workshop of a main machine learning...

nature.com
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Can a deep learning model know your data well enough to predict missing parts? InterpolAI accurately interpolates synthetic images between pairs of authentic images to “repair” tissue damage and reduce stitching artifacts across modalities. @deniswirtz bit.ly/453o1i1
Image from Nature Methods (@naturemethods)
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Oof Fridays are starting to be my least favorite day
Image from Dr. Pam R (@PamR33)
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I had the privilege of working with such talented scientists @jiayan_zhou03 @ifanirene @ZanettiD_ @ShoaClarke @tassimes @kristyredhorse
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Definitely @suhaasaz
Itai Yanai (@ItaiYanai) profile pictureItai Yanai
@ItaiYanai6 Oct 2024
Doing good science is 90% finding a science buddy to constantly talk to about the project.
Image from Itai Yanai (@ItaiYanai)
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I'm able to hire a second post-grad! If interested, please send me a cover letter + CV by October 1st
Dr. Sedona Murphy (@SedonaMurphy) profile pictureDr. Sedona Murphy@SedonaMurphy24 Apr 2024
Seeking someone looking for a two-year postbac position to get my group up and running at Yale University! We will be utilizing chromatin tracing and other multiplexed imaging approaches to study the relationship between 3D genome organization and epigenetic memory in embryos!
Image from Dr. Sedona Murphy (@SedonaMurphy)
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Dr. Pam R retweeted
nature (@Nature) profile picture
nature
@Nature30 Aug 2024
Nature research paper: Fibrin drives thromboinflammation and neuropathology in COVID-19 go.nature.com/3Z2IDDO
Fibrin drives thromboinflammation and neuropathology in COVID-19

Fibrin drives thromboinflammation and neuropathology in COVID-19

Nature - Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.

nature.com
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Tomorrow!! Join us for the #InFocusSession on Regulation of Endothelial Identity!! 🫸🫷💪😁 Register and details👉 conta.cc/3SJZ0k0
Image from NAVBO (@vascularbiology)
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The most exciting implications of my work is a layer of cell type specific epigenetic memory regulation through chromatin organization. Instead of a euchromatin and heterochromatin binary, differing degrees of chromatin stability may help to regulate plasticity:
Image from Dr. Sedona Murphy (@SedonaMurphy)
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Pre-print Alert! Intra-vital imaging of embryonic brains reveals pial collateral development by artery tip extension. @NCBS_Bangalore @vascularbiology @surajk23 @niloufershan @Swarnadipg98 @Vinayak5iv @DwariManish biorxiv.org/content/10.1101/…
Development of Pial Collaterals by Extension of Pre-existing Artery Tips

Development of Pial Collaterals by Extension of Pre-existing Artery Tips

Pial collaterals provide protection from ischemic damage and improve prognosis of stroke patients. The origin or precise sequence of events underlying pial collateral development is unclear and has...

biorxiv.org
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