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PennMuscle

@PennMuscle

The Pennsylvania Muscle Institute was created to discover the mechanisms of muscle function, muscle disease, and motile biological systems. | Also on Bluesky

 Philadelphia, PA
med.upenn.edu/pmi/
Joined February 2013
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Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)Photo by PennMuscle (@PennMuscle)
Join @PennMuscle on 12/5 for their symposium, “From Molecules to Movement: Cytoskeletal Insights into Muscle Function & Neuronal Health” ft'ing @BonifacinoJuan (@NIH), @SchnorrerL (@IBDMmarseille), @kjverhey1 (@UMich) & James Dowling (@PennNeurology) tinyurl.com/2thjcnx9
Image from Penn Medicine CSO (@PennMedCSO)
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Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging ft. @Charlie_R_Bond, @SHugelier, Jiazheng Xing, Elena Sorokina & @Melike_Lak (@UPennPhysiology/ @PennMuscle) rupress.org/jcb/article/224/…
Image from Penn Medicine CSO (@PennMedCSO)
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How myosin-I enhances pushing of branched actin networks, with Mengqi Xu, Michael Ostap and colleagues at UPenn, and modeling by David Rutkowski now published science.org/doi/10.1126/scia…
Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks

Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks

The myosin-I power stroke enhances the pushing forces generated by the actin cytoskeleton.

science.org
Dimitris Vavylonis (@DVavylonis) profile pictureDimitris Vavylonis@DVavylonis16 Feb 2024
Replying to @DVavylonis
A filament-level computational model recapitulated these myosin observations. In simulations, myosin pushing forces contributed significantly to bead propulsion after symmetry breaking.
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Visualization & quantification of organelle axonal transport in cultured neurons ft. @jayneaiken_ & @ErikaHolzbaur (@UPennPhysiology/ @PennMuscle) tinyurl.com/jwpv68ye
Image from Penn Medicine CSO (@PennMedCSO)
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Only 8 days left to submit your abstract for #bps2024. Don't miss your chance to present your work! The abstract submission deadline is October 1. Submit today ow.ly/sz1y50POlX2
Image from Biophysical Society (@BiophysicalSoc)
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Happy National Postdoc Appreciation Week!🔬👩‍🔬👨‍🔬🎉 This week, we celebrate & thank our incredible postdocs, whose exceptional work & dedication to advancing scientific knowledge is shaping the future of research & health care at @PennMedicine & beyond @PennBPP #NPAW2023
Image from Penn Medicine CSO (@PennMedCSO)
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New research suggests that stabilizing Hsp70-BAG interactions could be a novel therapeutic target for familial hypertrophic cardiomyopathy ft. @wagner_mj, Jaime Yob, @sday_hcm (@PennCardiology/ @PennCVI) & @Prosser_Lab (@UPennPhysiology) tinyurl.com/29kwwzqh
Image from Penn Medicine CSO (@PennMedCSO)
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Investigating actin filaments in #apicomplexan parasites using cryo-ET ft. @MattMartinez44, @MageswaranKumar, @AmandineGuerin5, William Chen, @yiweichang (@BB_UPenn), Cameron Thompson (@PennMuscle), Sabine Chavin (@PennSAS) & @striepenlab (@PennVet) t.ly/8lqIJ
Image from Penn Medicine CSO (@PennMedCSO)
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#ICYMI: $25M gift to @PennMedicine & @ChildrensPhila establishes new Center for Epilepsy & Neurodevelopmental Disorders🎉 ft. @Prosser_Lab (@UPennPhysiology), @lab_davidson (@PennPathLabMed), @IngoHelbig (@PennNeurology), Larry Jameson & @MadelineSBell bit.ly/3DKMGJK
Image from Penn Medicine CSO (@PennMedCSO)
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A tremendous thank you to Deans' Distinguished Visiting Professor Elizabeth Lennon of @pennvet who presented at yesterday's @UPennPhysiology/ @PennMuscle #PSOMDDVP seminar!🎉 For more information about the program & upcoming events➡️ bit.ly/37rjyrq
Image from Penn Medicine CSO (@PennMedCSO)
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Department of Physiology & Department of Neuroscience Joint Seminar: 2/3/23 from 12:00-1:00 in CRB702 (415 Curie Blvd.) or pennmedicine.zoom.us/j/99219… Speaker: Chen Ran, PhD, Harvard Medical School Title: "The coding of internal senses in the brain"
Image from UPenn Physiology (@UPennPhysiology)
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Recruitment Seminar 2/14/2023 @ 2:00pm Biomedical Research Building, Gaulton Auditorium or pennmedicine.zoom.us/j/99219… Speaker: Ashley Solmonson, PhD, Assistant Instructor, UT Southwestern Medical Center Title: "Dissecting developmental metabolism using rare genetic variants"
Image from UPenn Physiology (@UPennPhysiology)
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Faculty Recruitment Seminar 1/26/2023 @ 2:00pm Biomedical Research Building, Room 252 pennmedicine.zoom.us/j/99219… Speaker: Rosalie Lawrence, PhD - Title: "Metabolic mechanisms of cellular stress response"
Image from UPenn Physiology (@UPennPhysiology)
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Desmin intermediate filaments & tubulin detyrosination stabilize growing microtubules in cardiomyocytes💓 ft. Alexander Salomon, @Sai_entist, Naima Okami, @julieheffler, Patrick Robison, Alexey Bogush & @Prosser_Lab (@UPennPhysiology/ @PennMuscle) bit.ly/3NHNeDS
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Recruitment Seminar 1/9/2023 @ 2:00pm Clinical Research Building, Austrian Auditorium or pennmedicine.zoom.us/j/99219… Speaker: Kelsie Eichel, PhD, Postdoctoral Scholar, Department of Biology, Stanford University Title: " How to organize a neuron: insights from C. elegans to humans"
Image from UPenn Physiology (@UPennPhysiology)
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Leslie Leinwand never ceases to amaze on myosin modulation and sarcomere turnover, followed by @MAG2ART providing much needed visual evidence (and quant!) of how sarcomeres are formed. What a day! And now… cocktails, dinner, and challenging each others science. @PennMuscle
Image from Ben Prosser (@Prosser_Lab)
Image from Ben Prosser (@Prosser_Lab)
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Cheesin’ for the obligatory poster picture during @PennMuscle symposium! Great talks and had a blast talking about my science to those interested in THE best protein complex ever, Arp2/3 🫶🏻🥹 – at Philadelphia, PA
Image from Fred Erick Fregoso, PhD (@FregosoFred)
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Mike Ostap and Yale Goldman honoring the life and legacy of the late Saul Winegrad. #myotwitter @PennMuscle
Image from Ben Prosser (@Prosser_Lab)
Image from Ben Prosser (@Prosser_Lab)
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Next up brilliant presentations from @Wi_Roman and @KehatLab on myonuclear movement driving muscle repair, and a sub-cellular dissection of how and where new protein synthesis is controlled to build sarcomeres. #myotwitter @PennMuscle
Image from Ben Prosser (@Prosser_Lab)
Image from Ben Prosser (@Prosser_Lab)
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The @PennMuscle Symposium is underway! >100 muscle biologists together in a room with FANTASTIC speakers and discussion. @BayliesLab, Keita Uchida from my group and Nuoying Ma from @MourkiotiLab kicked off the morning session. I’m a kid in a candy store.
Image from Ben Prosser (@Prosser_Lab)
Image from Ben Prosser (@Prosser_Lab)
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