Radek Nowak (@RPNowak) header
Radek Nowak (@RPNowak) profile picture

Radek Nowak

@RPNowak

Professor @UniBonn. Former @DanaFarber @harvardmed | Targeted Protein Degradation | Chemical and Structural Biology | @UniofOxford alumni. Tweets are my own.

 Bonn, Germany
nowak-lab.com/
Joined November 2013
  • Tweets1.4K
  • Following721
  • Followers1.9K
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Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)Photo by Radek Nowak (@RPNowak)
Targeted protein #degradation: from mechanisms to #clinic. New molecular mechanisms can rapidly be translated - we can learn so much from nature. Great to be able to share this piece with @jonathanMtsai Ben Ebert and Eric Fischer @fischerlab1. #TPD nature.com/articles/s41580-0…
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Radek Nowak retweeted
Hojong Yoon (@hojong_yoon) profile picture
Hojong Yoon@hojong_yoonAug 5
Excited to share our latest work published today! linkedin.com/posts/hojong-yo…
Discovering Molecular Glues for E3 Ligases with Systematic Approach | Hojong Yoon posted on the...

Discovering Molecular Glues for E3 Ligases with Systematic Approach | Hojong Yoon posted on the...

Excited to share our latest work published today. Link: https://lnkd.in/g2KUcu-j This project started with a simple but challenging question: can we systematically discover molecular glues for a...

linkedin.com
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Radek Nowak retweeted
Lyn Jones (@LynJonesChemBio) profile picture
Lyn Jones@LynJonesChemBioJul 22
New bioRxiv preprint: covalent remodeling of CRBN locks His353 in a conformation that avoids the IMiD clash and polarizes the C2–H to form a new edge‑to‑face interaction with NTAQ1 Phe126. #TargetedProteinDegradation #MolecularGlue biorxiv.org/content/10.64898…
Covalent remodeling of CRBN creates a non-canonical neosubstrate interface with NTAQ1

Covalent remodeling of CRBN creates a non-canonical neosubstrate interface with NTAQ1

Molecular glue degrader EM12-FS covalently modifies cereblon (CRBN) His353, enabling selective recruitment of the neosubstrate NTAQ1 to the CRL4CRBN ubiquitin ligase. We determined the cryo-EM...

biorxiv.org
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Beautiful work identifying a novel degron-independent neo-substrate of CRBN, led by the KAT2A team — Samuel Ojeda and Meng Wang of the @fischerlab1!! Congrats to all involved! science.org/doi/10.1126/scie…
Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues

Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues

Lysine acetyltransferases (KATs) cooperate with oncogenes such as c-Myc, estrogen receptor, and lysine methyltransferase 2A (KMT2A) fusions to sustain malignant programs. Targeting of KAT proteins...

science.org
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NEW: today OpenBind ‘comes out of stealth’ so to speak with their first data dump of ~900 novel protein-ligand structures - most with paired affinities This represents a meaningful %-age increase in all of humanities P-L data in the PDB collected in the last 50 years More👇
Image from Charlie Harris (@charlieharris01)
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Radek Nowak retweeted
Ingo Hartung (@HartungIngo) profile picture
Ingo Hartung@HartungIngoApr 20
Nathanael Gray @StanfordUChem about bifunctional proximity-inducing molecules which allow to rewire transcription #AACR26. TCIPs hijacking BCL6, BRD4, CDK9, p300 and p53 Y220C as “synthetic hybride TFs” leading to transcriptional hyperactivation & gain-of-function pharmacology.
Image from Ingo Hartung (@HartungIngo)
Image from Ingo Hartung (@HartungIngo)
Image from Ingo Hartung (@HartungIngo)
Image from Ingo Hartung (@HartungIngo)
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📢 Save the Date for our DFCI Targeted Protein Degradation in-person Meeting!! 📍 Location: Boston, MA 📅 Date: September 10th, 2026 🔬 Talks from leaders in the field 🤝 Networking reception 🌍 Livestream available
Image from Katherine A Donovan (@kdonovan1008)
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Our new lab website is live! 👉 nowak-lab.com We are looking for a postdoc in #structuralbiology / #cryoEM to join our lab at the University of Bonn @UniBonn. Please share or reach out!

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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Induced proximity-based therapeutic modalities nature.com/articles/s41573-0… rdcu.be/eOfBH This new Review discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Image from Nature Reviews Drug Discovery (@NatRevDrugDisc)
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Was so much fun to be part of that journey! So much for the exciting science and most importantly friendships. To the next 10! @fischerlab1
Katherine A Donovan (@kdonovan1008) profile pictureKatherine A Donovan@kdonovan100822 Oct 2025
This month we celebrated a decade of the @fischerlab1 - 10 years of discovery, innovation, and collaboration! Thank you to everyone who’s been part of this journey — past and present lab members, collaborators, and supporters. Here’s to the next 10! 🧪🎉
Image from Katherine A Donovan (@kdonovan1008)
Image from Katherine A Donovan (@kdonovan1008)
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Excited to present our research at the Promega TPD and Induced Proximity Summit this Thursday! #TPD #UniBonn promega.foleon.com/na-tpd-sy…
Agenda - TPD and Induced Proximity 2025

Agenda - TPD and Induced Proximity 2025

promega.foleon.com
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Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18
Image from Steven Corsello (@corsellos)
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A new study in @MolecularCell by @DanaFarber’s @biomiko, Benjamin Ebert, MD, PhD, and @fischerlab1 reports a systematic screen of 9,000 zinc fingers revealing 38 new CRBN-recruited degrons. This includes targets invisible to proteomics, expanding the ZF proteome map to guide drug design and mitigate off-target toxicity. Read more: bit.ly/41XoG1Q
Image from Dana-Farber News (@DanaFarberNews)
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@DanaFarber @DanaFarberNews @broadinstitute @MassGeneralNews
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Thanks to all co-authors: @jeanniescience Simran Rastogi, Anna Goldstein, ​ Marek Nagiec, Kathrine Donovan, Jianwei Che, Moritz Hunkeler, Chi-Lin Hsu, Megha Lakshminarayan, Chelsea Shu @beckyzon @zkozicka Paul Park @jonathanMtsai @hojong_yoon @LynJonesChemBio @adamssperling
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This work was a fantastic collaboration: 🔬Structure: @jihojasonpark, @RPNowak, @ssroyburman - @fischerlab1 🧬 Functional Genomics: JessePellman, CharlesZou - Ebert lab ⚗️Chemistry: Hlib Razumkov, Qixiang Geng (Gray lab)
Image from Mikołaj Słabicki (@biomiko)
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A single ZF residue can switch a drug’s specificity. That’s a lever for rational molecular‑glue design.
Image from Mikołaj Słabicki (@biomiko)
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Chemistry rewires biology: subtle changes to glutarimide analogs reshape degron selectivity, reprogramming CRBN toward new ZF targets.
Image from Mikołaj Słabicki (@biomiko)
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Structure + mutagenesis reveal distinct CRBN recruitment modes—different substrates or drugs interact with different CRBN surfaces.
Image from Mikołaj Słabicki (@biomiko)
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CRBN is more versatile than expected: potent degraders can overcome β-hairpin mutations and still engage substrates.
Image from Mikołaj Słabicki (@biomiko)
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Degron profiling reveals hidden off-targets: OSR1 is not detected in proteomics experiments, yet emerges as a CRBN substrate. OSR1 plays a critical role in kidney development—highlighting potential clinical implications.
Image from Mikołaj Słabicki (@biomiko)
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