Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths) header
Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths) profile picture

Scientific lead of @ParisTxGroup

Paris, France
Joined September 2017
Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)Photo by Marc Raynaud πŸ‡«πŸ‡· (@Raynaud_Maths)
Marc Raynaud πŸ‡«πŸ‡· retweeted
trained fruit flies to play beer pond with each other cuz why not
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Marc Raynaud πŸ‡«πŸ‡· retweeted
🚨 Someone open sourced an entire animal. Not a model of an animal. The animal. A fruit fly, rebuilt joint by joint from microscopy, that walks, grips, flies and lands inside a physics engine running on your laptop. It's called flybody. Built by Google DeepMind and HHMI Janelia, published in Nature, and sitting on GitHub under Apache 2.0 right now. What's actually inside: A full body in MuJoCo. Legs, wings, head, abdomen, every joint articulated and physically simulated. A 59-dimensional action space in the walking task alone. That is how many things a network has to coordinate for the fly to take one step. Leg adhesion, so it actually grips surfaces instead of sliding off them like a game asset. Ready-made RL environments: walking imitation, free flight, and vision-guided flight where the policy flies on what the fly sees. The whole thing is Python. Clone it, open MuJoCo, and the fly is on your screen. And the part that got me: Nobody animated any of this. You hand the body to a reinforcement learning agent and it discovers how to move it. Same loop as a robot arm, except the robot is a bug and the reward is staying airborne. Which means people are now training it to do things no fly has done in 100 million years of evolution. 525 stars. Apache 2.0. Zero dollars.
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πŸš€ Proud moment for us at @ParisTxGroup ! We are delighted to share our new article showing the strong performance of #iBox across diverse cohorts, subpopulations, and clinical scenarios, published @BMJMedicine A key contribution of this work is the development and validation of additional flexible iBox algorithms, designed to adapt to differences in data availability across transplant centers worldwide. These findings further support iBox as a powerful tool for allograft risk stratification and clinical trial endpoint assessment, in the context of its ongoing @US_FDA qualification pathway. Congratulations to all co-authors and collaborators who made this possible. #KidneyTransplantation #Transplantation #Nephrology #ClinicalTrials #DigitalHealth #Biomarkers #iBox #PrecisionMedicine bmjmedicine.bmj.com/content/…
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With @ParisTxGroup and @AlexandreLoupy, at #esot2025, we have officially announced the world’s FIRST AI TRANPLANT CLINIC that will be launched in 2026 ! It will be a revolution for precision diagnostics, prognostics, patient monitoring and therapeutic simulation ! #AI #Transplantation
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πŸ“’ New publication in Xenotransplantation Journal by our group @ParisTxGroup @AlexandreLoupy ! Among the 2,900+ Xeno papers we assessed, 706 focused on solid organ & islet transplants from animals to humans 🐷➑️🧍 lnkd.in/eVKHzNVn Here’s a summary of what we found πŸ‘‡
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πŸ“ˆ Two peaks in research: πŸ”¬ 1990s – gene editing boom πŸ§ͺ 2020s – first pig-to-human kidney transplants But today’s surge is mostly reviews, not original data. πŸ›‘ Immunological barriers = most discussed challenge. πŸ“š Research still siloed in transplant journals.
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This study shows how #MetaResearch helps map progress, expose gaps, and guide future directions. Big congrats to Ivana Juric πŸ™Œ Thanks to all co-authors & collaborators for the amazing team effort!
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🚨 Just published in @NatureComms ! Our response with @DivardG and @AlexandreLoupy to the letter by Giorgakis et al. addresses the application of the Virtual Biopsy System for kidney transplants. Let's dive in! πŸ‘‡ nature.com/articles/s41467-0…
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2/3 πŸ”Giorgakis et al. raised concerns about false positives in high-risk settings. πŸ‘‰ While biopsies remain critical for complex cases, VBS is performant at identifying low-risk kidneys, safely omitting unnecessary biopsies and enabling quicker decisions. 🌟 VBS AUC range = 0.72–0.81 for ruling out severe lesions.
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3/3 πŸš€With multicenter validation (17 centers, 14,032 biopsies), the VBS is a tool to optimize kidney allocation globally. 🌍 We encourage further trials to show relevance in additional settings.
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πŸ™Œ Truly an amazing adventure. What a chance to work with such a talented team!
πŸ“’ Just published in @NEJM and presented at @ASNKidney #KidneyWk: Our study, analyzing over 16,000 biopsies from 30+ centers, provides insight into microvascular inflammation in kidney allografts. @AlexandreLoupy πŸ™Œ to @MartaSablik @A_Sannier @Raynaud_Maths Let’s dive into it πŸ‘‡
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Listening to Kevin Fowler @gratefull080504 a kidney recipient himself, on how involving patients in the clinical trial discussion #Banff2024 Leveraging the patient voice will help solve problems. @univ_paris_cite @ParisTxGroup
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Today, I stand at the war memorial at @Univ_Paris_Cite, dedicated to the physicians and medical students who gave their lives for France during WWI. As we gather for #Banff2024, their sacrifices remind us of the commitment to saving lives.πŸ•ŠοΈπŸ‡«πŸ‡· #PITOR #UPCitΓ© @ParisTxGroup
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And for the last day of @ATCMeeting, at the plenary session, we have THE @zpdemir2, who shows the associations between HLA immunogenicity and AMR. @ParisTxGroup #ATC2024Philly @APHP @AST_info
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Excited to attend a unique philosophical session @ATCmeeting, exploring deep questions: What is death? πŸ’€ What is courage? πŸ’ͺ What is a human? 🧬 Fascinating to see these profound discussions in the context of organ transplantation. #ATC2024Philly @ParisTxGroup @APHP @AST_info
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R Broussy is showing the impact of glomerulonephritis recurrence on kidney allograft survival. A very rare and insightful population-based study ! @brousse_romain @ParisTxGroup @ATCMeeting #ATC2024Philly
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