SNSF/EMBO Postdoc Fellow with @randall_platt | @ETH_BSSE prev. PhD @LemkeLab @EMBL & @uni_mainz creating synthetic organelles #condensates #synbio
Basel, Switzerland
Joined February 2020
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Ever wondered what a cell has experienced in the past? This is in general hard to measure. Here we introduce the recordanelle, to equip cells with a tool that lets them record their own history.
nature.com/articles/s41587-0…
@NatureBiotech @ETH @randall_platt @ETH_BSSE
This article nicely summarises our recordanelle work: ethz.ch/en/news-and-events/e…
Thanks to @ETH_en Corporate Communications for this nice article.
You can find the paper @NatureBiotech here: nature.com/articles/s41587-0…
Christopher Reinkemeier retweeted
One engineered protein, anchored to the mitochondria, builds a synthetic organelle that samples up to 90% of a human cell's mRNAs and protects them for days.
Earlier RNA recorders logged a few genes over a narrow window.
nitter.cf/ReinkemeierCD/status/2…
Ever wondered what a cell has experienced in the past? This is in general hard to measure. Here we introduce the recordanelle, to equip cells with a tool that lets them record their own history.
nature.com/articles/s41587-0…
@NatureBiotech @ETH @randall_platt @ETH_BSSE
Want to try out the recordanelle? All key plasmids are now available at @Addgene
➡️ addgene.org/browse/article/2…
Paper: nature.com/articles/s41587-0…
@NatureBiotech @randall_platt
#OpenScience #SynBio #scRNAseq
Thanks @RNASeqBlog for this very informative blog post summary of our recordanelle technology.
Direct link to the paper for more details ⬇️
nature.com/articles/s41587-0…
Researchers developed recordanelles that preserve RNA for days, allowing single-cell RNA sequencing to capture past gene activity and reveal temporary cellular responses that conventional methods may miss. - @ETH_en - @ETH rna-seqblog.com/recordanelle…
Interested in the story behind our recordanelle? Check out our Research Briefing:
➡️ nature.com/articles/s41587-0…
For the full paper: #OpenAccess ➡️nature.com/articles/s41587-0…
Thanks to @NatureBiotech for the editorial summary.
@randall_platt @ETH_BSSE @ETH_en
We also talk about how this project was started by my fabulous co-first author Marcos Manero-Carranza, during his Master thesis (for which he got an #ETHMedal).
Christopher Reinkemeier retweeted
Recordanelles: a nondisruptive and unbiased transcriptome-wide single-cell RNA recording technology to enable a deeper understanding of biology of human cells @NatureBiotech @randall_platt @ReinkemeierCD
nature.com/articles/s41587-0…
Christopher Reinkemeier retweeted
Recordanelles for transcriptome-wide single-cell RNA recording in human cells nature.com/articles/s41587-0…
Christopher Reinkemeier retweeted
Today in @NatureBiotech we introduce the "recordanelle", a synthetic organelle that enables transcriptome-wide single-cell RNA recording in human cells. Big thanks to team: @ReinkemeierCD, Marcos Manero-Carranza, et al. 🧵👇
@ETH_en @ETH_BSSE @BRC_CH
rdcu.be/5Pus7dyu63ta
Ever wondered what a cell has experienced in the past? This is in general hard to measure. Here we introduce the recordanelle, to equip cells with a tool that lets them record their own history.
nature.com/articles/s41587-0…
@NatureBiotech @ETH @randall_platt @ETH_BSSE
It does so without a measurable impact on viability, the cell’s proteome, the global transcriptome or the cell’s metabolism. Thus, this work provides a non-disruptive and unbiased transcriptome-wide single-cell RNA recording technology.
Christopher Reinkemeier retweeted
And the poster award winners:
Christopher Reinkemeier (ETH)
Guo-Teng Liang (Baylor)
Jeff Lotthammer (WashU)
Jake Simmons (UNC)
Sean Carney (NIH)
Nazanin Farahi (VIB)
Sveinn Bjarnason (Uni. Iceland)
Carla Garcia Cabau (IRB)
Carlos A. Elena-Real (FMP)
Marissa Zintel (Berkeley)
