Randall Platt (@randall_platt) header
Randall Platt (@randall_platt) profile picture

Randall Platt

@randall_platt

Associate Professor @ETH_BSSE | CRISPR molecular technology development | @UUtah - @ImperialCollege - @MIT - @BroadInstitute - @ETH_en

 Basel, Switzerland
platt.ethz.ch
Joined August 2015
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Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)Photo by Randall Platt (@randall_platt)
Today in @NatureBiotech we introduce the "recordanelle", a synthetic organelle that enables transcriptome-wide single-cell RNA recording in human cells. Big thanks to team: @ReinkemeierCD, Marcos Manero-Carranza, et al. 🧵👇 @ETH_en @ETH_BSSE @BRC_CH rdcu.be/5Pus7dyu63ta
Christopher Reinkemeier (@ReinkemeierCD) profile pictureChristopher Reinkemeier@ReinkemeierCDOct 21
Ever wondered what a cell has experienced in the past? This is in general hard to measure. Here we introduce the recordanelle, to equip cells with a tool that lets them record their own history. nature.com/articles/s41587-0… @NatureBiotech @ETH @randall_platt @ETH_BSSE
Recordanelles for transcriptome-wide single-cell RNA recording in human cells

Recordanelles for transcriptome-wide single-cell RNA recording in human cells

Nature Biotechnology - Recordanelles continuously and unbiasedly record the transcriptome throughout time in living mammalian cells.

nature.com
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This article nicely summarises our recordanelle work: ethz.ch/en/news-and-events/e… Thanks to @ETH_en Corporate Communications for this nice article. You can find the paper @NatureBiotech here: nature.com/articles/s41587-0…
New method reveals what a cell did days ago

New method reveals what a cell did days ago

Many biological molecules are short-lived and ephemeral. Now, researchers at ETH Zurich have developed an archive function that allows them to look into a cell’s past for the first time. This could...

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Want to try out the recordanelle? All key plasmids are now available at @Addgene ➡️ addgene.org/browse/article/2… Paper: nature.com/articles/s41587-0… @NatureBiotech @randall_platt #OpenScience #SynBio #scRNAseq

Addgene

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Recordanelle plasmids now available on @Addgene! addgene.org/browse/article/2…

Addgene

addgene.org
Randall Platt (@randall_platt) profile pictureRandall Platt@randall_plattOct 21
Today in @NatureBiotech we introduce the "recordanelle", a synthetic organelle that enables transcriptome-wide single-cell RNA recording in human cells. Big thanks to team: @ReinkemeierCD, Marcos Manero-Carranza, et al. 🧵👇 @ETH_en @ETH_BSSE @BRC_CH rdcu.be/5Pus7dyu63ta
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Interested in the story behind our recordanelle? Check out our Research Briefing: ➡️ nature.com/articles/s41587-0… For the full paper: #OpenAccess ➡️nature.com/articles/s41587-0… Thanks to @NatureBiotech for the editorial summary. @randall_platt @ETH_BSSE @ETH_en
Recordanelles capture transient gene expression in single human cells

Recordanelles capture transient gene expression in single human cells

Nature Biotechnology - RNA sequencing can capture high-resolution snapshots of a cell’s transcriptome, but transient changes in individual cells cannot be captured over long periods at a...

nature.com
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Recordanelles for transcriptome-wide single-cell RNA recording in human cells nature.com/articles/s41587-0…
Image from Nature Biotechnology (@NatureBiotech)
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Randall Platt retweeted
Jacob Corn (@jcornlab) profile picture
Jacob Corn@jcornlabMay 28
The preliminary program and registration is open for SwissPR 2026, happening in Basel at the Biozentrum on 30th June. Hear from @jpkbravo, @schmidburgk, @grunewaju, @MartinPacesa more. Register now at swisspr-symposium.uzh.ch/en.…
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Finding new medicines is getting more and more expensive, and AI won't help much unless we can generate physiological data at scale. In our new preprint, @GordianBio extends the progress of the functional genomics community to run pooled in vivo screens at scale, in a way that answers questions about physiology and therapeutic potential. We show screens in mice and horses, fibrotic and degenerative disease, with a framework for physiological predictions validated in human ex vivo tissues. Very proud of @v_sontake, @vkartha88, Neety and the rest of the team. Tweetorial follows:
Image from Martin Borch Jensen (@MartinBJensen)
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Job alert🚀We are recruiting a Bioinformatics Scientist to help guide the lab's computational research, contribute to ongoing projects, and pursue independent research. Come join us in Basel, Switzerland! More info at: tinyurl.com/nhe4epse @ETH_en @ETH_BSSE
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Just under one week to apply for this Research Technician position.
Randall Platt (@randall_platt) profile pictureRandall Platt@randall_platt5 Sep 2025
🚨Job alert 🚨We are recruiting a Research Technician, primarily with skills in molecular and cellular biology. Come join us in Basel, Switzerland! More info at: jobs.ethz.ch/job/view/JOPG_e…
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🚨 Computational postdoc Job alert 🚨We are recruiting a postdoc to focus on the development and application of computational methods for functional genomics. Come join us in Basel, Switzerland! More info at: jobs.ethz.ch/job/view/JOPG_e…
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🚨Job alert 🚨We are recruiting a Research Technician, primarily with skills in molecular and cellular biology. Come join us in Basel, Switzerland! More info at: jobs.ethz.ch/job/view/JOPG_e…
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In @NatRevGenet we outline strategies for in vivo pooled (single cell) CRISPR screens for genotype → phenotype mapping in animal models. This contains over a decade of hard earned knowledge by us and the field. Kudos to @AntonioSantinha & Alessio Strano. rdcu.be/eykft
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New online! Methods and applications of in vivo CRISPR screening bit.ly/40BAAy0
Image from Nature Reviews Genetics (@NatureRevGenet)
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In vivo CRISPR screens offer a unique way to study gene function at scale🐁. In our new @NatureRevGenet article, Alessio Strano, @randall_platt, and I review current methods, experimental designs, and explore exciting future directions!nature.com/articles/s41576-0… @ETH_en @ETH_BSSE
Methods and applications of in vivo CRISPR screening

Methods and applications of in vivo CRISPR screening

Nature Reviews Genetics - In vivo CRISPR screens generate high-throughput, unbiased genotype–phenotypes maps for complex biological processes that cannot be studied in vitro. This Review...

nature.com
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I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
Image from Martin Pacesa (@MartinPacesa)
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👏🏽 Big congrats to Costanza Borrelli who studied cell-cell interactions in the Lab of Andreas Moor, and Antonio Santinha from @randall_platt Lab, inventor of a novel technology for single-cell CRISPR screening, received the 2024 @ETH_en Medals🤩 > u.ethz.ch/ZOnc3
Image from D-BSSE, ETH Zurich (@ETH_BSSE)
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🚨Job alert🚨 We are recruiting a PhD student to work on the development of high-throughput protein perturbation technologies. Come join us in Basel, Switzerland! More info at: jobs.ethz.ch/job/view/JOPG_e…
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Randall Platt retweeted
Jacob Corn (@jcornlab) profile picture
Jacob Corn@jcornlab18 Dec 2024
I'm looking for a research #technician to help discover on how cells remove organelles. Are you skilled with #CRISPR, flow cytometry, and primary cell culture? Please apply! jobs.ethz.ch/job/view/JOPG_e…
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Replying to @NatureBiotech @randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel
Precision mutational scanning: your multipass to the future of genetics - @naturemethods N&V by @fjsanchezrivera nature.com/articles/s41592-0…
Precision mutational scanning: your multipass to the future of genetics

Precision mutational scanning: your multipass to the future of genetics

Nature Methods - Massively parallel base and prime editing screens provide unparalleled interrogation of genetic variants with single-nucleotide resolution.

nature.com
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