Kyriaki Karava (@k_karava) header
Kyriaki Karava (@k_karava) profile picture

Kyriaki Karava

@k_karava

Scientific Assistant and Animal Fact Enthusiast in the Platt Group, D-BSSE ETH Zürich. She/her.

 Basel, Switzerland
Joined February 2022
  • Tweets16
  • Following138
  • Followers54
Our manuscript on multimodal scanning of genetic variants is out! We utilize base and prime editing to examine the function of thousands of variants in EGFR activation and drug response. It’s very special to see my MSc work published in @NatureBiotech 🧵🔽 nature.com/articles/s41587-0…
Multimodal scanning of genetic variants with base and prime editing

Multimodal scanning of genetic variants with base and prime editing

Nature Biotechnology - Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.

nature.com
Olivier Belli (@olivier_belli) profile pictureOlivier Belli@olivier_belli12 Nov 2024
🚨 Very happy to announce the publication of my PhD work @NatureBiotech where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️ nature.com/articles/s41587-0…
Multimodal scanning of genetic variants with base and prime editing

Multimodal scanning of genetic variants with base and prime editing

Nature Biotechnology - Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.

nature.com
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Replying to @NatureBiotech @randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel
Combining base and prime editing to decipher which gene variants lead to cancer #NBTintheNews via @GENbio genengnews.com/topics/cancer…
Combining Base and Prime Editing to Decipher Which Gene Variants Lead to Cancer

Combining Base and Prime Editing to Decipher Which Gene Variants Lead to Cancer

Researchers at ETH Zurich combined two CRISPR-Cas methods to decipher how mutations in a cell’s genome affect its function. Their new approach can help determine which of the variants contribute to...

genengnews.com
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Replying to @NatureBiotech @randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel @GENbio
Multimodal editing maps genetic variants in EGFR #NBTintheNews via @CrisprMedicine crisprmedicinenews.com/news/…
Image from Nature Biotechnology (@NatureBiotech)
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Replying to @NatureBiotech @randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel
Precision mutational scanning: your multipass to the future of genetics - @naturemethods N&V by @fjsanchezrivera nature.com/articles/s41592-0…
Precision mutational scanning: your multipass to the future of genetics

Precision mutational scanning: your multipass to the future of genetics

Nature Methods - Massively parallel base and prime editing screens provide unparalleled interrogation of genetic variants with single-nucleotide resolution.

nature.com
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And read the News & Views from @fjsanchezrivera highlighting this work, along with related work published in @NatureBiotech from @randall_platt and colleagues, (nature.com/articles/s41587-0…), here: nature.com/articles/s41592-0…

Multimodal scanning of genetic variants with base and prime editing

Nature Biotechnology - Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.

nature.com
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Combining Base and Prime Editing to Decipher Which Gene Variants Lead to Cancer @ETH_en researchers combined two CRISPR-Cas methods to decipher how mutations in a cell’s genome affect its function. hubs.li/Q02Y3xbj0
Combining Base and Prime Editing to Decipher Which Gene Variants Lead to Cancer

Combining Base and Prime Editing to Decipher Which Gene Variants Lead to Cancer

Researchers at ETH Zurich combined two CRISPR-Cas methods to decipher how mutations in a cell’s genome affect its function. Their new approach can help determine which of the variants contribute to...

genengnews.com
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Replying to @NatureBiotech @randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel
Using CRISPR to decipher whether gene variants lead to cancer #NBTintheNews via @ETH_en ethz.ch/en/news-and-events/e…
Using CRISPR to decipher whether gene variants lead to cancer

Using CRISPR to decipher whether gene variants lead to cancer

Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of...

ethz.ch
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Exciting research on using #CRISPR to decipher whether gene variants lead to #cancer and advancing base and prime editing tools by @randall_platt @ETH_en > u.ethz.ch/7ohcV
Using CRISPR to decipher whether gene variants lead to cancer

Using CRISPR to decipher whether gene variants lead to cancer

Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of...

ethz.ch
Nature Biotechnology (@NatureBiotech) profile pictureNature Biotechnology
@NatureBiotech12 Nov 2024
Multimodal scanning of genetic variants with base and prime editing go.nature.com/3O6wQ0O
Image from Nature Biotechnology (@NatureBiotech)
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Kyriaki Karava retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol12 Nov 2024
One of the major challenges in human genomics is the functional assessment of variants. Base and prime #CRISPR genome editing is making a big difference for meeting that challenge, as exemplified in this new report @NatureBiotech nature.com/articles/s41587-0… @randall_platt @olivier_belli @k_karava @ETH
Multimodal scanning of genetic variants with base and prime editing

Multimodal scanning of genetic variants with base and prime editing

Nature Biotechnology - Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.

nature.com
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Multimodal scanning of genetic variants with base and prime editing go.nature.com/3O6wQ0O
Image from Nature Biotechnology (@NatureBiotech)
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Kyriaki Karava retweeted
ETH Zurich (@ETH_en) profile picture
ETH Zurich@ETH_en12 Nov 2024
Researchers at ETH Zurich have combined two #GeneEditing methods. This enables them to quickly investigate the significance of many #GeneticMutations involved in the development and treatment of #Cancer. brnw.ch/21wOzs3
Using CRISPR to decipher whether gene variants lead to cancer

Using CRISPR to decipher whether gene variants lead to cancer

Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of...

ethz.ch
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Today in @NatureBiotech we report on the use of base and prime editing for high throughput interrogation of genetic variants in cancer. Excellent work by first authors @olivier_belli & @k_karava. 🧵👇 tinyurl.com/2js9dwyp @ETH_en @ETH_BSSE
Olivier Belli (@olivier_belli) profile pictureOlivier Belli@olivier_belli12 Nov 2024
🚨 Very happy to announce the publication of my PhD work @NatureBiotech where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️ nature.com/articles/s41587-0…
Multimodal scanning of genetic variants with base and prime editing

Multimodal scanning of genetic variants with base and prime editing

Nature Biotechnology - Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.

nature.com
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Replying to @k_karava @NatureBiotech
What’s equally special is learning from and collaborating with incredible scientists like @olivier_belli and doing impactful research! It’s been such a great learning experience and a truly fun and rewarding collaboration!
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Very grateful to my supervisor @randall_platt for his continuous support and guidance throughout this time, and many thanks to the wonderful people of the Platt group for making this possible. What an amazing journey!
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Programming diverse neuron subtypes from stem cells! Coupling patterning with proneural TF induction, we screened for 480 morphogen signaling modulations in ~700K cells. Great work with @JasperJanssens7 @TreutleinLab @GrayCampLab biorxiv.org/content/10.1101/…
Image from Hsiu-Chuan Lin (@HsiuChuan_Lin)
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New university students have suffered particularly from the measures and restrictions during the #pandemic. #KyriakiKarava and #FlorianHugi, members of our new #Biotechnology Master student cohort report on their experiences at D-​BSSE >bit.ly/3MOzHtf @k_karava @ETH_en
Image from D-BSSE, ETH Zurich (@ETH_BSSE)
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