Lab of Michael Rout @RockefellerUniv | NCDIR member (@IntActOme) | Interactomics, NPCs, nuclear transport & making nanobodies https://nitter.cf/t.co/5nEKSfKwZe
Rockefeller University, NYC
Joined March 2023
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Incredibly excited to share this paper with the community! Congratulations authors including @DrMartyTaylor, @dfhoyosg, @ArthurZalevsky, the amazing team at @rome_tx led by Donna Romero, @macro_momo, @bengrbm, Eddy Arnold @RutgersU, Matthias Götte @UAlberta, & @KathleenHBurns
So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature nature.com/articles/s41586-0…
You thought it was gone but it's back! Incredibly happy to have this story out now at @NatureCellBio: nature.com/articles/s41556-0…
Don't spend restless nights worrying about the dynamics of nuclear transport. Read our latest review and rest easy!
portlandpress.com/biochemsoc…
Also thank you @RockefellerUniv for this wonderful profile! rockefeller.edu/news/38697-n…
Rout Lab retweeted
This was a true team effort across HUJI, UCSF/QBI, Rockefeller, Einstein, Basel, and UCSD/HHMI. Immense thanks to our colleagues and collaborators. @salilab_ucsf @RoutLab_RU, @DavidCowburn1 , @TheVillaLab (special shoutout to @dgvjayS), and the Lim lab.
Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of nucleocytoplasmic transport:
pnas.org/doi/10.1073/pnas.25…
Rout Lab retweeted
A new @PNASNews study from @RoutLab_RU, working with a team led by the Hebrew University of Jerusalem, solves the long-standing mystery of how NPCs make split-second decisions about which molecules to allow to pass through their molecular gates: bit.ly/4hleGGd
Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of transport through NPCs.
pnas.org/doi/10.1073/pnas.25…
And highlights from @RockefellerUniv rockefeller.edu/news/38480-n… and @physorg_com phys.org/news/2025-10-molecu…
Congratulations all authors, particularly @dgvjayS @neeleshsoni03 @JoshHutchings94 who led this heroic effort on the first molecular model of the NPC nuclear basket. Out now in @CellCellPress
Our work on the architecture and model of the #NuclearBasket is now out @CellCellPress. cell.com/cell/pdf/S0092-8674…. @HHMINews, @IntActOme #NPC #teamtomo
A short tweetorial follows
Amazing! Congrats Steve
Excited to share our short review on the challenges of applying single-particle cryo-EM to RNA structures and some of the methods developed to overcome them. Hope you find it useful! sciencedirect.com/science/ar…
Rout Lab retweeted
From preprint to journal. Our nuclear gatekeepers have successfully unlocked the gates to Cell (Journal) cell.com/action/showPdf?pii=… #NPC #integrativemodeling Congrats to team @dgvjayS @JoshHutchings94 @ig_ech @RoutLab_RU @salilab_ucsf @TheVillaLab Animation youtube.com/watch?v=LiKdFIxr…
Tiny gatekeepers of our nucleus decide what gets in and out. Follow our study on Yeast and Mammalian NPC baskets and unravel the molecular structure of these cellular bouncers! Don't miss the side-by-side comparison in the video. #IntegrativeModeling biorxiv.org/content/10.1101/…
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In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).
Rout Lab retweeted
In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).
Rout Lab retweeted
It cannot be done, they said.. It's too flexible, they said.. 😁
biorxiv.org/content/10.1101/… #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf
Rout Lab retweeted
Rockefeller's @SanfordMSimon featured in @guardian for his work on fibrolamellar carcinoma, a rare liver cancer:
“The moment I learned of Elana’s condition is seared into my memory. I was determined to find out what caused it and find ways to counter it."
theguardian.com/science/2024…
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Collaborative work led by @svenklumpe resolves the structure of a mobile genetic element inside of developing tissue. Together with @juliusbrennecke @BriggsGroup and the fabulous Jürgen M Plitzko. #cryoET
biorxiv.org/content/10.1101/…
Rout Lab retweeted
Dynamin-like proteins at the nuclear envelope? That and other surprises in excellent work by @PhilipMannino1 with help from @NicholasAder @TJ_MeliaLab and @LuskingL! #autophagy
biorxiv.org/content/10.1101/…
Rout Lab retweeted
Postdocs! Apply now for the Exceptional Scholars Workshop, a program for mentorship of postdoctoral fellows from underrepresented or disadvantaged groups as they enter prepare for the faculty search and interview process. More info here: ruscholars.rockefeller.edu
Rout Lab retweeted
.@udi_yael et al. @RoutLab_RU present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. hubs.la/Q02jSHrM0
In our Tools collection: hubs.la/Q02jSK0L0
Rout Lab retweeted
First paper: nature.com/articles/s41586-0…
by @DrMartyTaylor @macro_momo @rome_tx @bengrbm @RoutLab_RU @KathleenHBurns and many others not on X.