Ruffell Lab (@Ruffell_Lab) header
Ruffell Lab (@Ruffell_Lab) profile picture

Ruffell Lab

@Ruffell_Lab

Cancer immunology lab @MoffittResearch investigating the role of dendritic cells and macrophages in breast and prostate cancer.

labpages2.moffitt.org/ruffell/
Joined March 2021
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  • Followers559
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Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)Photo by Ruffell Lab (@Ruffell_Lab)
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity dlvr.it/TGhVzG
Image from Cancer Cell (@Cancer_Cell)
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Excited to share our latest by @Triantafyllia14 where we find that IFNg acts as a metabolic switch to prune tumor-associated lymphangiogenesis and unlink immune surveillance and metastasis biorxiv.org/content/10.1101/… #theLundLab
IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in...

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in...

Lymphatic vessels play a crucial role in activating anti-tumor immune surveillance but also contribute to metastasis and systemic tumor progression. Whether distinct lymphatic phenotypes exist that...

biorxiv.org
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#ScienceSaturday ➡️ Did you know that some chemotherapies can enhance the immune response against #cancer?   ❓ How might we potentiate this?   ➡️ @Ruffell_Lab and colleagues from @moffittnews found that the necrotic cell death induced by #chemotherapy releases IL-1 alpha which induces immunosuppressive myeloid cells. Inhibiting IL-1 alpha in combination with chemotherapy enhanced antitumor responses. ‼️ This may be a promising approach for future clinical trials. 🔗 Here’s a link to the full study- cell.com/cancer-cell/abstrac… @Cancer_Cell
Image from Dr. Patrick Hwu (@PatrickHwuMD)
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People, the IL-1 pathway is SO RELEVANT in cancer 🔥🔥 IL-1a released from dying tumor cells dampens anti-tumor immunity by recruiting immune suppressive myeloid cells - this limits efficacy of chemo and ICB by Brian Ruffel in @Cancer_Cell cell.com/cancer-cell/fulltex…
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression...

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression...

Hänggi et al. investigate how tumor necroptosis regulates anti-tumor immunity and find an unexpected role for interleukin-1α (IL-1α) release by dying cells in promoting tumor growth by driving...

cell.com
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Online Now: Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity dlvr.it/TGJwxg
Image from Cancer Cell (@Cancer_Cell)
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Check out our latest paper “Differentiation fate of a stem-like CD4 T cell control immunity to cancer”, led by @Maria_Carden1 now live @Nature tinyurl.com/33d24k89 . This work examines how CD4 T cell differentiation dictates the outcome of the cancer response. Thread below
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Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇nature.com/articles/s41586-0…
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Congratulations Dr. Liu @SitemanCenter and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM . And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.
Image from David DeNardo WUSM (@DeNardoLabWUSM)
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Our review on a topic we eagerly enjoy exploring in the lab- how our fav immune cell types influence/are influenced by metabolic disorders preceding cancer- so much to learn! 👏🏻👏🏻 to #DanielTaranto for leading the effort, to @djkloosterman and the whole lab for their input! 🔥🔥
Nature Reviews Cancer (@NatureRevCancer) profile pictureNature Reviews Cancer@NatureRevCancer2 Oct 2024
NEW content online! Macrophages and T cells in metabolic disorder-associated cancers go.nature.com/4duhbCv
Image from Nature Reviews Cancer (@NatureRevCancer)
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I’m excited to announce that the TMC has received support to conduct an open rank (tenure-track or midcareer) cluster hire of 3-5 investigators interested in unraveling features of the tumor microenvironment to propel the understanding and treatment of cancer. 2/
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Very happy that our review in Nat Rev Imm is out! Trying to shed some light on the many knowns and even more unknowns of homeostatic dendritic cell maturation with @Victor_Bosteels @InflamResCen
Nature Rev Immunol (@NatRevImmunol) profile pictureNature Rev Immunol@NatRevImmunol17 Sep 2024
Striking a balance: new perspectives on homeostatic dendritic cell maturation dlvr.it/TDLpt2
Image from Nature Rev Immunol (@NatRevImmunol)
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Excited to share our new story from the lab in close collaboration with the Love lab @kochinstitute. Here is brief summary: ever wondered where T cells expand following immune checkpoint blockade therapy? The answer is in the white pulp of the spleen.
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1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine. science.org/doi/10.1126/scie… Here is a summary of what we discovered!
In vivo dendritic cell reprogramming for cancer immunotherapy

In vivo dendritic cell reprogramming for cancer immunotherapy

Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor...

science.org
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Thrilled to share our first study on aging from @MiriamMerad lab @IcahnMountSinai @TischCancer @SinaiImmunol in which we demonstrate how aging promotes cancer. We show that: (1/n) science.org/doi/10.1126/scie…
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis

Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis

Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor,...

science.org
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I am excited to share our @NatureComms paper describing the structure of #LAG3 bound to MHC-II. This project was carried out by @SuperMQQ et al at @MoffittResearch and provides new insights into the mechanism by which LAG3 suppresses T cell activation. nature.com/articles/s41467-0…
Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab

Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab

Nature Communications - Lymphocyte activation gene-3 (LAG3) is an immune checkpoint protein recently approved as a target for anti-melanoma therapy. Here, the authors solve the structure of mouse...

nature.com
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1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer #micronuclei is out in @ScienceMagazine today. A story led by the brilliant @melodyDiBona it started with a simple question: why do micronuclei rupture? science.org/doi/10.1126/scie…
Image from Samuel Bakhoum (@Samuel_Bakhoum)
Image from Samuel Bakhoum (@Samuel_Bakhoum)
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Paper 🚨! Ecstatic, proud, grateful …Years of dedication from the whole lab, with the exceptional @djkloosterman and the one of a kind #JohannaErbani at its helm. What a journey all the way to @CellCellPress! How did it start (& end)? A 🧵1/n cell.com/cell/fulltext/S0092…
Macrophage-mediated myelin recycling fuels brain cancer malignancy

Macrophage-mediated myelin recycling fuels brain cancer malignancy

Recycling of cholesterol-rich myelin debris by macrophages leads to the emergence of lipid-laden macrophages (LLMs) in glioblastoma. LLMs support glioblastoma malignancy through transfer of myelin-...

cell.com
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CRI is proud to share the new cohort of Lloyd J. Old STARs! Meet the researchers who will receive $1.25 million over 5 years to drive high-risk, high-reward projects with the potential to transform cancer treatment and advance the frontiers of the field: bit.ly/3YAZIVd
Image from Cancer Research Institute (@CancerResearch)
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Ruffell Lab retweeted
Meng-Ju Wu (@MJWu_TW) profile picture
Meng-Ju Wu@MJWu_TW11 Jul 2024
New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/scie… #CancerResearch #Cholangiocarcinoma #IDH1 1/n

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity

Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes...

science.org
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We are delighted to share our new study on FLT1 activation and PARP inhibitor resistance in breast cancer. This study was led by Yifan Tai, an exceptional Masters student from Columbia Univ. Biotech Program. Congratulations to all the co-authors and collaborators!
EMBO Mol. Medicine (@EmboMolMed) profile pictureEMBO Mol. Medicine@EmboMolMed4 Jul 2024
Online this week! FLT1 activation in cancer cells promotes #PARPinhibitor resistance in #BreastCancer By Yifan Tai, Anup Biswas, @SwarnaliAchary5 & colleagues @ColumbiaMed 🗞️doi.org/10.1038/s44321-024-0…
Image from EMBO Mol. Medicine (@EmboMolMed)
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