@SGinossarLab

Virus-host interactions @WeizmannScience

 Israel
weizmann.ac.il/molgen/ginossar/
Joined November 2018
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Our new paper is out @Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx
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Corcoran Lab@corcoran_lab
Sep 16
Thrilled to share our most recent paper. Led by the amazing @marielkleer, we show that a viral RNA called kaposin drives nuclear speckle seeding beside the KSHV viral genome, an event which optimizes viral gene expression. sciencedirect.com/science/ar…
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nature
@Nature
Sep 4
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome go.nature.com/4gOtwFr

Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome

Nature - Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.

nature.com
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Moshe Biton@bitonm
May 13
Excited to share our new paper in Nature Immunology! 🦠🔬 nature.com/articles/s41590-0… We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection. A huge thanks to all collaborators and team members who made this work possible!

An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella...

Nature Immunology - Salmonella-invaded intestinal stem cells activate an inflammasome-driven differentiation program toward antimicrobial Paneth cells, revealing a protective stem cell defense...

nature.com
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NatureStructMolBiol@NatureSMB
May 1
New online! Direct roles of long non-coding RNAs in transcription activation dlvr.it/TSK9MJ
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We are excited to share our new paper in Molecular Cell uncovering how the viral lncRNA RNA2.7 reshapes host cell biology! sciencedirect.com/science/au… A thread 🧵
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RNA2.7 alone is sufficient for inducing a cell cycle arrest, even outside of the context of infection. A tiled screen discovered an adenine-rich region which is required for this function.
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Overall, our study demonstrates that RNA2.7 reshapes RNA biology in the infected cell sequestering RBPs and modifying RNA stability. Functionally it contributes to the complex cell cycle arrest phenotype mediated by HCMV and is important for the infection of rapidly cycling cells
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Tomorrow at the #SystemsVirologyJournalClub, @FinkelYaara will present her work with @SGinossarLab on engineering HCMV to express sgRNA libraries directly from the viral genome to profile virus–host interactions across the infection cycle. Paper: pubmed.ncbi.nlm.nih.gov/3883…

A virally encoded high-resolution screen of cytomegalovirus dependencies - PubMed

Genetic screens have transformed our ability to interrogate cellular factor requirements for viral infections1,2, but most current approaches are limited in their sensitivity, biased towards early...

pubmed.ncbi.nlm.nih.gov
Shira Weingarten-Gabbay@WeingartenShira
20 Oct 2025
🚨 Systems Virology Journal Club – 8th Series! 🚨 @wm_schneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration: shiraweingartengabbay.com/sy… 🔬✨
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Nitzan Tal@Nitzan_T
Mar 6
Very excited to see this work out today @ScienceMagazine! Discovering viral proteins that block immune signaling from predicted protein structures🤩 science.org/doi/10.1126/scie… Huge thanks to the amazing collaborators! 🤗 Linking previous thread on our findings below 👇

Structural modeling reveals phage proteins that manipulate bacterial immune signaling

Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and...

science.org
Nitzan Tal@Nitzan_T
13 Jul 2025
📢Preprint out! Excited to share my final work from the @Soreklab! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!
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Molecular Cell@MolecularCell
Feb 5
Why m⁶A? An RNA surveillance model. @SchragaSchwartz and colleagues review recent findings about the interplay between RNA methylation and the RNA processing machinery to propose a surveillance model for m6A. dlvr.it/TQnVtP
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MicrobeTV@profvrr
Jan 25
TWiV explains emergence of a neurovirulent double recombinant from the 'improved' nOPV2 in Uganda, and efficiency of viral entry determined whether cells are latently or lytically infected with cytomegalovirus. 📺 bit.ly/4t48I28
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Yaarit Kitsberg@Yaarit12
Jan 25
This week, the virology podcast TWiV discussed our recently published paper on how HCMV entry dictates infection outcome. Listen from minute 55: lnkd.in/dJvTdZVb @SGinossarLab Thanks, TWiV, for the thoughtful feedback and comments!

LinkedIn

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lnkd.in
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Thomas Norman@thenormanlab
Jan 20
New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
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Amazing work by Shevie, Karin and Rajan, and a great fruitful collaboration across biology and structural biology @WeizmannScience and around the globe.
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