Designer of genomes, phage enthusiast, rock climber, views are my own.
Zurich, Switzerland
Joined January 2018
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I am thrilled to announce that PhalconBio has secured £1 million grant funding from @PACE_AMR to propel our lead anti-Pseudomonas program.
Thank you for the support and recognition of our platform technology! 🚀💪🥂
#phage #engineering #AMRsolutions
phalconbio.com/news/pace
Urine Good Hands! Engineered phages to detect and treat #UTIs.
🙏 to @phagedirectory for publishing an interesting behind-the-scenes article.
🙏@MattDunne_1 Jiemin Du @MeileSusanne @MartinLoessner @PhageForward @LeitnerLorenz Thomas Kessler and team!
phage.directory/capsid/urine…
What happens when you combine two #precision #antimicrobials?
➡️Enhanced #UPEC killing using #engineered #phages that release a #colicin from infected target-bacteria!
➡️See effect of this two-pronged attack in green (supplementary data from rdcu.be/dhi2D)
Samuel Kilcher retweeted
Pathogens that cause urinary tract infections #UTIs are becoming increasingly resistant to #antibiotics. ETH researchers developed a rapid test and a new therapeutic approach using bacteria-infecting viruses known as #phages.@SamuelKilcher @MattDunne_1 fal.cn/3A4Gy
2 papers out @NatureComms: #Engineered #phages to detect (rdcu.be/dhi2N) and treat (rdcu.be/dhi2D) #UTIs. Big team effort! 🙏🙏🙏 to @MeileSusanne Jiemin_Du @MartinLoessner @MattDunne_1 + >20 contributors @eth_en @derbalgrist @UZH_en
Pic: Happy last authors 😀
Help us bring engineered phage therapy to life! We are looking for a motivated research scientist to join our @Micreos antimicrobial vector innovation team in Switzerland. You can find more details here:
linkedin.com/jobs/view/33892…
(Application through LinkedIn)
For #phage #engineering geeks:
If you are interested in modifying the genomes of virulent #Enterococcus phages, you may want to have a look at Figure 2 of our recent preprint.
🧬Cas9 is a highly efficient counter-selection tool 🧬
🧬100 % success rate🧬
biorxiv.org/content/10.1101/…
Great study covering many applications of phage engineering. Congrats!
Really enjoyed seeing in vivo data comparing wildtype vs. replication-deficient phages 👍
Congrats to our team!
Synthetic engineering and biological containment of bacteriophages.
pnas.org/doi/10.1073/pnas.22…
Proud to present our work on engineered #phage-based urine #diagnostics. Huge team effort led by @MeileSusanne Jiemin Du @MattDunne_1 + much support from @LeitnerLorenz @PhageForward Thomas Kessler @MartinLoessner + 16 more authors! @ETH_en @derbalgrist
biorxiv.org/content/10.1101/…
Nice phage engineering work-around for phiKZ-like jumbo phages!
Here, @jingwen_guan presents a new way to engineer phage genomes, using Cas13a + an Acr protein! We developed this because our favorite jumbo phage, phiKZ had no genetic tools. We are now using this to understand the jumbo phage secrets. short🧵biorxiv.org/content/10.1101/…
How to tackle #UTIs with engineered #phage? Proud to present: biorxiv.org/cgi/content/shor…. Big shout-out to first authors Jiemin Du + Susanne Meile and co-corresponding @MattDunne_1. Thanks @LeitnerLorenz, Thomas Kessler, and @MartinLoessner for all the support! @ETH_en @derbalgrist
Samuel Kilcher retweeted
Out today👨🔬! Characterization of tail fibers and tailspikes from broad range E. coli #phages EP335 and EP75. Shout out to co-authors Sander Witte & Joel T. van Mierlo @Micreos, @LeaZinsli, Cassie Matter & @MartinLoessner @ETH, & Rafael G-Serrano. 👏
sciencedirect.com/science/ar…
Nothing cheers me up more than marveling at cumulative incidence curves of the Pfizer/BioNTech and Moderna vaccines 😅 #VaccinesWork
Excited to share our thoughts on improving #phagetherapy through #synbio and genome engineering:
authors.elsevier.com/sd/arti…
Congrats to the 2 first authors @FlyGeneticsGuy and Bryan Lenneman and to @MartinLoessner and @timlu for a great collaboration.
Artwork by @FlyGeneticsGuy
Samuel Kilcher retweeted
BREAKING NEWS:
The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
Another great example of phage-antibiotic synergy, congrats! Phage-resistance often comes at a cost: incrased antibiotic susceptibility, decreased virulence, etc... #CombinationTherapy
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Samuel Kilcher retweeted
Interested in #geneticengineering of reporter #phages to improve bacterial diagnostics? 🤔 Our design principles are available today at @VirusesMDPI! Special thanks to 1st author Susanne Meile 👏🏼, @MartinLoessner, and fellow phage engineer @SamuelKilcher. doi.org/10.3390/v12090944
Samuel Kilcher retweeted
When you get a draft back from your supervisor or collaborator and it is covered in comments....
Each comment does not mean, "I think your draft is bad."
Each comment means, "I care about your work, and about you."
#PhdChat #AcademicChatter
Excellent read: #Phage- and #CRISPR-assisted gut microbiome engineering! Congrats @itskathylam and @PTurnbaugh.
biorxiv.org/content/10.1101/…
