Gould Lab studies roles of #BasementMembrane and #ECMatrix, and finds cures of a multi-system disorder #GouldSyndrome caused by mutations in #collagenIV.
UCSF, San Francisco, CA
Joined April 2020
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Today April 12th is #GouldSyndromeAwareness Day because this disease is caused by mutations in the Col4⃣ a1⃣ and a2⃣ genes. Please find your time to watch this 4 min video
👇👇👇
youtu.be/VLWm_Cns99Y via @YouTube
Gould Lab UCSF retweeted
Thank you for advertising our new preprint, Yutaka! 📢
If you are interested in prolyl 4-hydroxylation and collagen biosynthesis, you can learn how these go in Drosoplia ‼️🪰🪰🪰
Happy Friday 😎
Our preprint is out!
Great collaboration with @yoshihiro0604, @mel_toups, Marwan Elkrewi, Allison Zajac, and @SHBLab
Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV
(13 posts follow) ↓
biorxiv.org/content/10.1101/…
Gould Lab UCSF retweeted
Please add your reading list! Our shiny collagen IV paper is out now😎 Enjoy beautiful red and green images! Yes, I MUST do molecular characterization of this "beauty" collagen IV... My TO-DO list is too much😅
@UCSFGouldLab
Mao et al introduce a novel tagged Col4a1 mouse model for studying basement membrane dynamics, which provides important details of COL4A1 turnover in cerebral vasculature & shows that Col4a1 heterozygous deletion is better tolerated than missense mutations hubs.la/Q03jWjdz0
Gould Lab UCSF retweeted
My first post of 2025 is here! 😎 Excited to share my new paper on horse collagen I 🐎. We explored COL1 structure and modifications in horses with LH1 mutations. Don’t miss the unique images of twisted collagen fibrils—check it out below!👇👇👇
Biochemical characterization of collagen I in Warmblood Fragile Foal Syndrome horse lysyl hydroxylase 1 mutation. #micropublication #biology #data #caltechlibrary # quus caballus #Biochemistry #NewFinding micropublication.org/journal…
Gould Lab UCSF retweeted
Interesting collaboration coming from the @UCSFGouldLab and @TamaraAlliston lab to identify an unexpected role of #collagen type IV in bone biology in connection with #TGFβ bit.ly/3BxKlDy
Gould Lab UCSF retweeted
Want to learn about #GouldSyndrome? Check out this month's featured #CCMBM #MSK member publication from @UCSFGouldLab & @TamaraAlliston: "Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling." sciencedirect.com/science/ar…
Thank you for letting us know, Xin!
Please check this link 👇👇
doi.org/10.1016/j.matbio.202…
Gould Lab UCSF retweeted
Douglas Gould @UCSFGouldLab et al. investigate whether TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage, iovs.arvojournals.org/articl….
Gould Lab UCSF retweeted
We are please to announce Drs. Yoshi Ishikawa @yoshihiro0604 and Masashi Yanagisawa as the Luncheon Seminar speakers at #JSMBM24. 日本結合組織学会大会のランチョンセミナーはUCSF のYoshi Ishikawa 先生によるコラーゲンのフォールディング、Masashi Yanagisawa 先生による睡眠の講演です！
Gould Lab UCSF retweeted
What an incredible first day at the #Alportworkshop on #WorldKidneyDay - so much has happened in the last 10 years & always so good to catch up with #basementmembrane friends ❤️@JeffMinerPhD @UCSFGouldLab @SherwoodElegans @stramerlab
Exciting news! Our new research paper is published! This exciting study was done with a amazing collaborator Scott Early (@vesselman) lab. Congratulations🎉🍻🥳
In a model of #GouldSyndrome, researchers connect brain lesions and hemorrhages to disruptions in #CalciumSignaling in smooth muscle cells from misfolded collagen, impairing vessel’s ability to regulate cerebral blood flow. @UCSFGouldLab @CobreUnr scim.ag/4Qh
#GouldSyndrome had great chemistry with #AlportSyndrome and basement membrane researchers at #ASMB2023! It is important to know each other, exchange ideas, and discuss future collaborations in person. I and @yoshihiro0604 are happy to be in this picture! Join Collagen IV biology!
Charismatic #AlportSyndrome and basement membrane researchers at #ASMB2023 @amsocmatbio enjoying some "networking time" together after a full day of scientific sessions in SLC. Thanks to @AlportSyndFndn for generously supporting the conference! @RLWczyk @BoudkoSergei @RW_Naylor
Gould Lab UCSF retweeted
Looking for another exciting #ECMatrix conference before our biennial meeting? Check out the #Collagen #GordonConference, where our very own ASMB council member Doug Gould @UCSFGouldLab is vice-chair! 👇
grc.org/collagen-conference/…
We appreciate that someone like our study and share it with Twitter community! Thank you!
#NAVBO Member Publication Alert
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in #GouldSyndrome
Dr. Scott Earley group @PNASNews 2023 @UCSFGouldLab @vesselman
pnas.org/doi/full/10.1073/pn…
Beautiful work Earley lab! What a great collaboration!
Our latest preprint provides proof of concept for the use of PI3K inhibitors to treat vascular dementia. @UCSFGouldLab @unrmed @DoctorMC_
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease biorxiv.org/content/10.1101/…
Please check this latest publication we involved about Gould syndrome! Great work and excellent collaboration! Cheers! 👍🎉
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…
Check out out latest paper, part of an amazing collaboration with @UCSFGouldLab !
Check our new paper!! Thank you @Xiaowei71 😊
check out recent work from @UCSFGouldLab on how Col4 is involved in vascular function through TGFb pathway. New insights for vascular pathologies including CSVD and @GouldSyndrome AddThis | Home authors.elsevier.com/c/1gCCz…
Congratulations to Danielle @RyansMom2, Sheena, and everyone with @GouldSyndrome
I am so proud to share the very first manuscript out of the @GouldSyndrome Global Registry! @SheelMd @UCSFGouldLab @LisaMarieShank sciencedirect.com/science/ar…