State-of-the-Art diagnostics and management of myeloid malignancies in Birmingham.
Birmingham
Joined November 2022
- Tweets109
- Following126
- Followers84
- Likes50
UHBMyeloid retweeted
In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P
Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors nej.md/3N0pQW8
ALT Panel A: A figure showing the change in the sum of diameters of the target lesions across tumor types. Panel B: A figure showing the overall duration of treatment and the time to first response observed in 46 patients treated with a dose in the observed efficacious-dose range who had wild-type KRAS.
UHBMyeloid retweeted
ICYMI - Self assessment deadline is now just over 2 weeks away. If you are struggling with what to write regarding your annual allowance, see my video from the weekend below 👇
NEW VIDEO ALERT! 🎥🚨
Help with 25/26 annual allowance & self assessment? Watch below! 👇
Covers:
• SA101/SA100 reporting for AA charge
• What is scheme pays
• Scheme pays cost
• SPE2 application (England/Wales/NI/Scotland)
youtu.be/CF1Pa5f3uug
UHBMyeloid retweeted
Newly diagnosed acute myeloid leukemia in unfit patients: 2026 treatment algorithms nature.com/articles/s41408-0… #AML #leusm @n_gangat
UHBMyeloid retweeted
DNMT3A, TET2, and ASXL1 mutations differentially shape the subsequent evolutionary trajectories of AML from diagnosis through relapse. ow.ly/rXck50VFJea #myeloidneoplasia
Thanks @HaemOnc, @VidhyaMurthy1, Hayley @UHBResearch, @charliecraddock, @h4yder for another great West Mids Myeloid Day on relapsed refractory #AML,high risk#MDS, and #CML. And cases from Richard Whitmill and Matt Kandathil @RWT_NHS – at Birmingham, England
UHBMyeloid retweeted
Why do AML patients with African ancestry have poor outcomes? Fascinating results indicate that genetics alter AML biology. Also, its Bailee Kain's first co-first author postdoc pub. @Bailee_Kain @AkEisfeld @nsalomonis and Elaine Mardis
nature.com/articles/s41588-0…
UHBMyeloid retweeted
Hugely important talk from @drpramilak on impact of ethnicity on patient outcome in AML. Emerging evidence of distinct disease biology and decreased transplant access contributing to worse outcomes. Vital area for research and action- supports launch of UK Myecare AML Registry.
We are very saddened at the sudden passing of our colleague and friend @SandeepNagra who supported the transplant and haematology team for many years. She will be dearly missed by us and many patients who she helped. Our sincere condolences to her family at this time – at London, England
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@HaemOnc latest in low risk #MDS and inherited risks in #AML highlighting work by @LabMonteiro @Farhat_Khanim @neilvmorgan @HrushiVyas @REPAIR_MDS – at London, England
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Great regional myeloid meeting at Exchange @unibirmingham with @WMRGL @VidhyaMurthy1 giving changes in guidances for #aml treatment – at Birmingham, England
UHBMyeloid retweeted
Brilliant work by my colleague @lymphomule. Most MYC/BCL6r lymphomas harbour a single-hit, reciprocal translocation t(3;8) between MYC and BCL6 (pseudo double-hit) and have better outcomes than t(3;8) negative double-hit cases. doi.org/10.1182/blood.202402…
UHBMyeloid retweeted
@UhbTeam @francescakinse3 @HaemOnc @h4yder @dr_peted @charliecraddock
Our second regional myeloid update day with focus on MPN. Great talks and fantastic case studies from colleagues.
UHBMyeloid retweeted
Thanks to @TheEBMT @Mohty_EBMT Myriam labopin and the ALWP team for this analysis and @charliecraddock for inspiration in clinic!- kinetics of CR induction matters to post allo sct prognosis.
#OpenAccess | Initial response to chemotherapy as determined by number of courses to attain complete remission (CR), retained prognostic relevance even following stem cell transplant in CR.
acsjournals.onlinelibrary.wi…
@OncoAlert
UHBMyeloid retweeted
Delighted to share our @NatureProtocols paper containing a detailed protocol for generating human bone marrow organoids. Amazing teamwork from the organoid crew @MRC_WIMM @UniofOxford led by the unstoppable @AbAttacks 🎉👇👇👏🏻
Morning everyone! Pleased to share a detailed protocol of our bone marrow organoid approach in @NatureProtocols :
nature.com/articles/s41596-0….
UHBMyeloid retweeted
Blast-reduction strategies in MPN-AP/BP most commonly result in reversion to chronic phase MPN with significant residual disease burden. ow.ly/sg9A50QMWGa #myeloidneoplasia
UHBMyeloid retweeted
Management of adult patients with CMML undergoing allo-HCT: recommendations from the EBMT PH&G Committee ashpublications.org/blood/ar… #CMML #leusm
UHBMyeloid retweeted
'We passionately believe that critical appraisal of trials is a core skill that all healthcare professionals should be able to perform.'
We interview Drs Rich Buka and Pip Nicholson on their new podcast series discussing non-malignant haematology.
ow.ly/Brpo50QQ72u
