Weston Kightlinger (@WKightlinger) header
Weston Kightlinger (@WKightlinger) profile picture

Weston Kightlinger

@WKightlinger

Scientist and founder using cell-free and other biomanufacturing technologies to improve medicine | @NorthwesternEng PhD | @Swiftscalebio | Resilience

 San Francisco, CA
linkedin.com/in/weston-kightlinger
Joined April 2012
  • Tweets31
  • Following131
  • Followers139
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Photo by Weston Kightlinger (@WKightlinger)Photo by Weston Kightlinger (@WKightlinger)
We're looking for a Glycoengineering Scientist to join our team. If you or anyone you know loves all things #glycoproteins #glycosylation #glycotime #glycoscience #glycans please reach out to help buildout an emerging platform and accelerate therapeutics manufacturing! #hiring
Image from Weston Kightlinger (@WKightlinger)
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Thanks Ben!
Ben Schulz (@bnschlz) profile pictureBen Schulz@bnschlz3 Jul 2020
Replying to @claudiaevickers @WKightlinger @ACSSynBio @ktwarfel @DeLisaGroup @mattdelisa
Fantastic review Weston and co!
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Our Synthetic Glycobiology review is @ACSSynBio! Whether you're a glycobiology purist or a synbio gene wrangler, make it your go-to review for all the exciting things bridging #glycotime and #synbio! Thanks @jewettlab_NU @ktwarfel @DeLisaGroup @mattdelisa!pubs.acs.org/doi/abs/10.1021…
Synthetic Glycobiology: Parts, Systems, and Applications

Synthetic Glycobiology: Parts, Systems, and Applications

Abstract. Protein glycosylation, the attachment of sugars to amino acid side chains, can endow proteins with a wide variety of properties of great interest

pubs.acs.org
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Thanks to @NUSynBio @NorthwesternU @NorthwesternEng... Go 'Cats!
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Weston Kightlinger retweeted
Michael C. Jewett (@MichaelCJewett) profile picture
Michael C. Jewett@MichaelCJewett30 Jun 2020
How sweet it is. Our new review on synthetic glycobiology for the #synbio audience is out. @WKightlinger @ktwarfel @mattdelisa @NUSynBio describe recent innovations and #glycotime applications, from manufacturing medicines to materials. #bioeconomy pubs.acs.org/doi/10.1021/acs…
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Weston Kightlinger retweeted
ACS Central Science (@ACSCentSci) profile picture
ACS Central Science@ACSCentSci24 Feb 2020
Check out #ASAP research by Michael C. Jewett @jewettlab_NU, Milan Mrksich & team @NUSynBio on sequential glycosylation of proteins with substrate-specific N-Glycosyltransferases: pubs.acs.org/doi/10.1021/acs…
Image from ACS Central Science (@ACSCentSci)
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Check out our latest paper with Liang Lin @mrksich with a creative way to create defined glycoproteins in vitro! We discovered new enzyme specificities to install multiple unique glycans on a single target protein. @jewettlab_NU @NUSynBio #glycotime pubs.acs.org/doi/10.1021/acs…
Sequential Glycosylation of Proteins with Substrate-Specific N‑Glycosyltransferases

Sequential Glycosylation of Proteins with Substrate-Specific N‑Glycosyltransferases

Abstract. Protein glycosylation is a common post-translational modification that influences the functions and properties of proteins. Despite advances in m

pubs.acs.org
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Weston Kightlinger retweeted
Josh Leonard (@TheLeonardLab) profile picture
Josh Leonard@TheLeonardLab7 Feb 2020
COMET - a platform for composing gene expression for mammalian synthetic biology - is out today! @NatureComms  nature.com/articles/s41467-0…
Image from Josh Leonard (@TheLeonardLab)
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Excited to share my latest paper with Jose Marc Techner that was just accepted at Analytical Chemistry! We provide a high-throughput way to synthesize and analyze intact glycoproteins using CFPS and SAMDI-MS. pubs.acs.org/doi/10.1021/acs… @jewettlab_NU @DeLisaGroup @mrksich @NUSynBio
High-Throughput Synthesis and Analysis of Intact Glycoproteins Using SAMDI-MS

High-Throughput Synthesis and Analysis of Intact Glycoproteins Using SAMDI-MS

Abstract. High-throughput quantification of the post-translational modification of many individual protein samples is challenging with current label-based

pubs.acs.org
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#glycotime
Image from Weston Kightlinger (@WKightlinger)
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Weston Kightlinger retweeted
Michael C. Jewett (@MichaelCJewett) profile picture
Michael C. Jewett@MichaelCJewett6 Dec 2019
⁦@WKightlinger⁩ ⁦@Stjle⁩ ⁦@PardeeLab⁩ ⁦@ozalabCP⁩ jewettlab ⁦@NUSynBio⁩ reuinion at the cell freesystems19 conference
Image from Michael C. Jewett (@MichaelCJewett)
Image from Michael C. Jewett (@MichaelCJewett)
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Had an amazing time at the Cell-Free Systems conference in Boston this week connecting with the fantastic people in the community.
Michael C. Jewett (@MichaelCJewett) profile pictureMichael C. Jewett@MichaelCJewett6 Dec 2019
⁦@WKightlinger⁩ ⁦@Stjle⁩ ⁦@PardeeLab⁩ ⁦@ozalabCP⁩ jewettlab ⁦@NUSynBio⁩ reuinion at the cell freesystems19 conference
Image from Michael C. Jewett (@MichaelCJewett)
Image from Michael C. Jewett (@MichaelCJewett)
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Weston Kightlinger retweeted
TeselaGen Biotechnology (@TeselaGen) profile picture
TeselaGen Biotechnology@TeselaGen2 Dec 2019
#Cellfree #SyntheticBiology Comes of Age: Cell-free systems stand to dramatically impact society, from the environment to medicine to education buff.ly/2swdX0u #synbio @jewettlab_NU
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Weston Kightlinger retweeted
SynBioBeta (@SynBioBeta) profile picture
SynBioBeta
@SynBioBeta28 Nov 2019
New Method Accelerates Development of Protein #Therapeutics: Cell-free system allows researchers to quickly find new pathways bit.ly/34rNcbQ #synbio @jewettlab_NU
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Weston Kightlinger retweeted
Ross Cloney (@rosscloney) profile picture
Ross Cloney@rosscloney29 Nov 2019
.@jewettlab_NU, @mattdelisa, and @NUSynBio build GlycoPRIME for constructing protein glycoslyation pathways go.nature.com/33x43J0 Out now @NatureComms
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Weston Kightlinger retweeted
Ross Cloney (@rosscloney) profile picture
Ross Cloney@rosscloney29 Nov 2019
.@jewettlab_NU, @NUSynBio provide us with guidelines on expanding the genetic code using flexizymes go.nature.com/37P0Nft Out now @NatureComms
Expanding the limits of the second genetic code with ribozymes

Expanding the limits of the second genetic code with ribozymes

Nature Communications - Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of...

nature.com
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Weston Kightlinger retweeted
Michael C. Jewett (@MichaelCJewett) profile picture
Michael C. Jewett@MichaelCJewett29 Nov 2019
Cell-free systems are enabling on-demand biomanufacturing, portable diagnostics, and next-generation educational kits. Read about how cell-free systems have come of age with @smashty @NUSynBio @adsilverman627 Thanks to all who helped with this and for the opportunity to write it
Nature Reviews Genetics (@NatureRevGenet) profile pictureNature Reviews Genetics@NatureRevGenet29 Nov 2019
Cell-free gene expression: an expanded repertoire of applications go.nature.com/2OvJ7h1 #Review by Adam D. Silverman, Ashty S. Karim & Michael C. Jewett (@jewettlab_NU)
Image from Nature Reviews Genetics (@NatureRevGenet)
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Great write-up by @NorthwesternEng and @NorthwesternU on our GlycoPRIME paper! “The dream is to create new-to-nature glycoproteins that could be made on-demand to develop new types of protein medicines.” @jewettlab_NU mccormick.northwestern.edu/n…
New Method Accelerates Development of Protein Therapeutics

New Method Accelerates Development of Protein Therapeutics

Northwestern Engineering researchers have developed a quick, cell-free system to create biosynthetic pathways to build and study sugar structures.

mccormick.northwestern.edu
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Very excited to share our latest work on "A Cell-free Biosynthesis Platform for Modular Construction of Glycosylation Pathways" published in Nature Comms today! This unlocks new ways to build glycoproteins by design! @jewettlab_NU @NUSynBio #glycotime nature.com/articles/s41467-0…
A cell-free biosynthesis platform for modular construction of protein glycosylation pathways

A cell-free biosynthesis platform for modular construction of protein glycosylation pathways

Nature Communications - Constructing biosynthetic pathways to study and engineer glycoprotein structures is difficult. Here, the authors use GlycoPRIME, a cell-free workflow for mixing-and-matching...

nature.com
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Fantastic job and huge thank you to my coauthors @JessicaCStark @mattdelisa @_aravindnat and @DeLisaGroup @mrksich and more!
Weston Kightlinger retweeted
Michael C. Jewett (@MichaelCJewett) profile picture
Michael C. Jewett@MichaelCJewett27 Nov 2019
It's GlycoPRIME for #glycotime. Check to this news story on our new method for constructing biosynthetic pathways to study and engineer precise glycan structures on proteins. @WKightlinger @JessicaCStark @DeLisaGroup @mattdelisa @_AravindNat and more. nature.com/articles/s41467-0…
A cell-free biosynthesis platform for modular construction of protein glycosylation pathways

A cell-free biosynthesis platform for modular construction of protein glycosylation pathways

Nature Communications - Constructing biosynthetic pathways to study and engineer glycoprotein structures is difficult. Here, the authors use GlycoPRIME, a cell-free workflow for mixing-and-matching...

nature.com
Northwestern Engineering (@NorthwesternEng) profile pictureNorthwestern Engineering@NorthwesternEng27 Nov 2019
Researchers in Northwestern's Center for Synthetic Biology have developed a new cell-free system to build and study biosynthetic pathways. The system could lead to a modular way to make medicines on demand in resource-limited settings. bit.ly/2DoHA6k @jewettlab_NU
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