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RNA Therapeutics in Cancer

@WittrupLab
Joined August 2018
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Anders Wittrup (@wittrup_anders) profile picture
Anders Wittrup@wittrup_anders27 May 2020
Very honored to have our recent Nat Comm paper selected as "Paper of the Month" in the nucleic acid therapeutics field. Highlights that "endosomal escape" is one of the key areas of development for oligo drugs! @hdurietz @PNordenfelt @WittrupLab @LuWcmm
Oligonucleotide Therapeutics Society (@OTSociety) profile pictureOligonucleotide Therapeutics Society@OTSociety27 May 2020
The OTS April'20 Paper of the Month is: "Imaging small molecule-induced endosomal escape of #siRNA" @hampois @wittrup_anders $ARWR $DRNA $ALNY $ABUS $SLN $AMGN @OliXPharmaceut1 #RNAi @RNAi_papers @StevenDowdy9 @mfosborn @socheata @oligogirl oligotherapeutics.org/april-…
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One step closer to RNA therapeutics against cancer. Our new methods to detect and enhance endosomal escape in cancer cells and tumor spheroids is now out in Nat Comm: nature.com/articles/s41467-0….
Imaging small molecule-induced endosomal escape of siRNA

Imaging small molecule-induced endosomal escape of siRNA

Nature Communications - Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor...

nature.com
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