@wyssinstitute
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The Wyss Institute seeks to transform engineering, medicine and the environment by creating new materials and devices using Nature’s design principles.
Harvard University
Joined April 2010
- Tweets12.9K
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- Followers28.2K
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Prior to the Wyss' founding in 2009, a working group at Harvard University assembled envision the future of biomedical engineering. Now, we see the how this foundation led to successful technologies positively impacting human and planet health.
wyss.harvard.edu/media-post/…
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Pulling carbon into seawater using engineered bacteria #NBTintheNews via @wyssinstitute wyss.harvard.edu/news/pullin…
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Engineered bacterial siderophore production accelerates rock weathering for carbon removal nature.com/articles/s41587-0…
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Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells nature.com/articles/s41587-0…
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Excited to share a link to our new ms in BioRxiv! It showed that BBB expression of brain shuttle receptors is stable between brain regions, diseases (AD, PD, ALS, HD) and ages in human subjects. Expression between individuals varied > 10x. biorxiv.org/content/10.64898…
Translating protein recognition into DNA single-molecule readout: a nanopore digital immunoassay for sensitive plasma biomarker quantification.
Read it here 🔗 go.acs.org/dYw
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Ever wonder what a nervous system would look like if it self-assembled inside a novel being that hadn't faced a history of selection for its organism-level form and function? Or, perhaps you wondered how #Xenobots would look and act, or what their transcriptome would be like, if they had nervous systems?
Well, here's the first step: advanced.onlinelibrary.wiley…
"Engineered Living Systems With Self-Organizing NeuralNetworks: From Anatomy to Behavior and Gene Expression"
Our awesome team: led by @halehf: @LaurieONeill99, @mmsperry, @LPiolopez, @DrPatrickE, and Tiffany Lin.
The @TuftsUniversity and @wyssinstitute press releases are here, for summaries:
now.tufts.edu/2026/03/16/sci…
wyss.harvard.edu/news/toward…
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Manufacturing-aware generative models enable petascale synthesis of designed DNA go.nature.com/3NxXt1I
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Our grantee @wyssinstitute is harnessing the power of Artificial intelligence to accelerate the development of transformative medicine, diagnostics, and medical devices, ushering in a new era of accuracy and efficiency in healthcare. 👩⚕️💻🧬
wyss.harvard.edu/news/transl…
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Digital SHERLOCK: Rapid Detection and Resistance Profiling of Candida auris
dSHERLOCK, a rapid CRISPR-based diagnostic, detects Candida auris and #antifungalresistance mutations in patient samples in under an hour
@wyssinstitute
#CRISPR #Candida
hubs.li/Q03-Z7S30
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Our new publication:
Plasmid2MC: efficient cell-free generation of high-purity minicircle DNA for genome editing in mammalian cells
nature.com/articles/s42003-0…
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Engineered base editors with reduced bystander editing through directed evolution - @rmperrotta @geochurch go.nature.com/4qmupbv
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PROTON illustrates how AI can propose testable hypotheses and candidate interventions in neurology.
I am grateful to the interdisciplinary team behind this work, supervised by @marinkazitnik:
• @HarvardDBMI: Joaquín Polonuer, @lvvittor, @InakiArango, @_michellemli
• @BrighamWomens: Xinyuan Wang, @snz20, Richard C. Krolewski, @khurana_lab*
• @wyssinstitute: Katharina Meyer, Bogdan Budnik, Shad Morton, Matthew Woodworth, @NinningLiu, @geochurch, @jenny_m_tam*
• @MassGeneralNews: Yingnan He, @sdas617*
• @broadinstitute: @tkam80, @macosko
• @MSKCancerCenter: Dylan Ritter, Jalwa Afroz, Alexander Henderson, @studerl
• @FutureHouseSF: @SGRodriques, @andrewwhite01
• @ClalitInnovate @ClalitHealth: Noa Dagan
• @UniofOxford: David Clifton
Thank you to the funders and supporters of our research, including @ASAP_Research, @BD2Discoveries, @gatesfoundation, @ChanZuckerberg, @harvard_data, @KempnerInst, @rhodes_trust, @ycombinator, and many others. [7/8]
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A personalized biomaterial #CancerVaccine just passed its first-in-human test!
Started by Drs. Stephen Hodi and David Mooney's labs at the @wyssinstitute in 2013, the trial showed that the system can be consistently fabricated and applied to patients: bit.ly/3KPfHe0
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✂️ #CRISPR research by Dr. George Church (@geochurch) inactivated all 62 copies of porcine endogenous retrovirus.
🐖 Now, eGenesis at @wyssinstitute & @harvardmed builds upon this work to develop safe and effective pig organs for #xenotransplantation: bit.ly/4iAZKV7
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Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets go.nature.com/4rBC1Z0
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💡 Researchers from the @WyssInstitute have showed they can use messenger RNA to activate the pathway and trigger the immune system to attack tumors!
Check out the work from Dr. @NatalieArtzi's lab in PNAS: bit.ly/4oBNqGe
Press release: bit.ly/447OtFD
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Researchers harness tumor cells to boost antitumor immunity in preclinical cancer models, in a new @PNASNews study.
Read more: massgeneralbrigham.org/en/ab… pnas.org/doi/10.1073/pnas.24… @NatalieArtzi @wyssinstitute
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A nonsurgical brain implant enabled through a cell–electronics hybrid for focal neuromodulation go.nature.com/3JuSNYH
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Clinical researchers and bioengineers at SEAS and the @wyssinstitute have developed slowly biodegradable, injectable biomaterial scaffold vaccines that could solve the problem of device infection in patients.
bit.ly/4qGx8xl
ALT knee replacement patient being examined by doctor
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We’re excited to share a new multi-year collaboration with @TakedaPharma, building on the success of our first engagement. Under the agreement, Nabla will receive double-digit millions in upfront and research payments and is eligible for success-based payments exceeding $1 billion.
The partnership deploys Nabla’s AI-driven JAM platform across Takeda’s early-stage programs to include de novo design of antibodies in parallel for multiple targets, multispecifics, challenging targets, and other custom therapeutics.
Read more below