G2 MD-PhD Candidate @StanfordMed, Khavari Lab | MSc Philosophy, Science, & Religion @EdinburghUni | BS @Yale, @lemmonferguson lab
Palo Alto, California
Joined February 2021
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- Following542
- Followers204
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David Lu retweeted
New Online! Regulation of RNA-binding proteins by small biomolecules bit.ly/4nME6OF
David Lu retweeted
Nature research paper: irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA
go.nature.com/3Y6lNtF
David Lu retweeted
Assessing the functionality of over 4,000 genome variants for their role in cancer, with prominence of impact for those related to the immune system and chronic inflammation
nature.com/articles/s41588-0…
I just read a recent Nature paper that only used one shRNA per gene for their knockdown experiments, didn't do any rescue experiments verifying that the shRNA-induced phenotype was an on-target effect, AND didn't even show qPCR or Western Blots confirming gene knockdown🤦♂️🤦♂️🤦♂️
David Lu retweeted
“There are not, and will never be, KRAS inhibitors” 👀
@Pasca_Lab presents a memorable reviewer comment from her 1st unfunded NIH grant at #AACRPan24.
The lesson is that you should not let deflating reviewer comments define the value of your science. Also, persistence!
David Lu retweeted
Always ask what the training set is. ML models have their uses, and those uses are often close to home. We need more things directed at target selection & clinical outcomes, but also a LOT more data there to make the models work.
science.org/content/blog-pos…
David Lu retweeted
Have been sitting on this for a few days and am now really excited to share *4* papers just published online today in @CD_AACR, with variations on the theme of cancer cell #plasticity as a mechanism of resistance to #KRAS inhibition aacrjournals.org/cancerdisco… (🧵)
David Lu retweeted
It had me at "the normal intact adult pancreas harbours hundreds of pancreatic intraepithelial neoplasias (PanINs), almost all with oncogenic KRAS hotspot mutations"
Spatial omics of pancreatic cancer
nature.com/articles/s41586-0…
@Nature @lauradelongwood @deniswirtz @AshleyKiemen
Really cool studies show that Alanyl-tRNA synthetase (AARS1) lactylates two of the most important proteins in cancer (YAP and P53)
Treating cancers with beta-alanine inhibited lactate binding to AARS1 and in vivo tumor growth!
cell.com/cell/fulltext/S0092…
jci.org/articles/view/174587
David Lu retweeted
Now online in @CD_AACR: Passenger Gene Co-Amplifications Create Collateral Therapeutic Vulnerabilities in Cancer - by @_YiBei,
@anton_gh, Jan Dörr, and colleagues doi.org/10.1158/2159-8290.CD… @DKTK_ @ChariteBerlin @MDC_Berlin @berlinnovation
I thought I was the only one who felt this way in Teslas! Glad to know there are others
David Lu retweeted
Why inhibit only one KRAS mutant when you can inhibit multiple KRAS alterations at the same time.
Our pan-KRAS inhibitor paper is out.
nature.com/articles/s41586-0…
What are we doing here, people? Apparently cancer has been cured and it’s not even funny! Looks like I’m going to have to find a new career… 😂😂😂
This. Is. Amazing.
This is a real opportunity: Panda Express Postdoctoral Fellowship in Asian American Studies at the University of Pennsylvania!
bit.ly/3Ofidtf
David Lu retweeted
Great to see this collaborative study of ALK in neuroblastoma published - with the labs of our friends Yaël Mossé and Ravi Radhakrishnan:
nature.com/articles/s41467-0…
David Lu retweeted
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics go.nature.com/3zC9k3a #Review by Sophia K. Longo, Margaret G. Guo, @andrewlji & Paul A. Khavari @Stanford @StanfordCancer