John De Vos (@_jdevos_) header
John De Vos (@_jdevos_) profile picture

#stemcells researcher | Director of Cell Processing Facility @umontpellier @CHU_Montpellier | #iPScells #lung | @stemgenomics

Montpellier, France
Joined July 2009
Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)Photo by John De Vos (@_jdevos_)
It's already been 20 years since Kazutoshi Takahashi and Shinya Yamanaka published their landmark paper on iPSCs in Cell. Amazing how a single publication could spark an entire field! #iPSCell nature.com/articles/s41556-0…
11
449
Last night an AI agent performed brain surgery on a mouse. We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures. It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding. A licensed vet gated every irreversible step and held a physical kill switch to stop the AI agent. Thread on what it decided, what it saw, and the moment it refused to let me override it. [Writing this on the spot out of excitement, but I've been 18hrs in front of my laptop coding and coordinating this, so keeping it brief and descriptive, more cohesive thoughts on this soon...]
307
1,255
656
9,507
1,639,040
John De Vos retweeted
'The Child' is one of three new limited-edition prints available now at tomgauld.com/shop
5
57
7
299
9,345
This is a great loss for the #DevBio community and the #SCBEM field in particular. Marta was (how hard to write this) a positive person, a creative scientist & a great collague. Will be missed.
1
11
1
51
5,741
The Singularity is coming for Physics and Biology. RIP Math.
105
651
112
6,888
635,462
VERY encouraging Phase 1 data for FT819: #iPSC-derived allogeneic #CARTcells show a promising safety profile and early signs of efficacy in lupus nephritis! Small cohorts and preliminary results, but an exciting step for off-the-shelf cell therapies. biospace.com/press-releases/…
2
5
299
Après des jours à dire que Parcoursup c’était une plate-forme de « matching »et que les filtres étaient définis par les universités et écoles, je découvre cette vidéo d’un prof et elle est juste parfaite. À visionner. 👇🏻👇🏻
Replying to @CoppeliaMoreau
Quel est le véritable problème avec #Parcoursup ? Un prof répond :
53
410
11
1,273
78,708
Our "Single-cell multi-omics in IPF & COPD: from atlas to impact" is out! We provide a brief guide to analytic approaches, an overview of how the technologies impact our understanding of the 2 diseases, limitations, future directions. A 🧵 will follow publications.ersnet.org/cont…
3
23
1
81
6,659
A first for CRISPR: powerful prime editing alters DNA directly in the human body #GeneTherapy nature.com/articles/d41586-0…
1
3
139
John De Vos retweeted
Just published @ScienceMagazine Higher medical accuracy at lower cost A 3-agent AI for sequential diagnosis nearly doubled accuracy compared with physicians for >300 @NEJM CPC cases and >300 ER cases AND substantially lowered cost, also exceeded performance of many AI models, physicians plus AI @HarshaNori @erichorvitz @Dominic1King @mustafasuleyman
40
129
19
497
61,812
John De Vos retweeted
This is 100% correct.
I don’t think Europeans fully appreciate what is happening to the European Union right now. The EU is under an extraordinary, multi-front assault, both from outside and from within. And I struggle to think of another period in its history when so many powerful actors had an interest in weakening it simultaneously. Russia has spent years waging hybrid warfare against Europe. Weaponised migration, sabotage, cyberattacks, coordinated disinformation campaigns, bot networks and political interference. The objective is clear: undermine trust in democratic institutions, deepen social divisions and weaken European unity. China has different motivations, primarily economic and geopolitical. A fragmented Europe is easier to pressure, easier to negotiate with individually and less capable of defending its economic interests. And then there is the United States. Perhaps the most disturbing development of all. Under Trump and MAGA, a country that helped rebuild the old continent and then spent decades supporting European integration now has an administration openly hostile to much of what the EU represents. Its own National Security Strategy even calls for cultivating resistance to Europe’s current political direction. Think about that for a moment. Meanwhile, within Europe, parts of the far right and far left amplify these divisions, whether through ideological alignment, political opportunism or outright sympathy for authoritarian regimes. This doesn’t mean Russia, China and MAGA are all following some jointly coordinated master plan. They don’t have to. Their interests increasingly overlap, and Europe’s internal divisions make their work considerably easier. What makes this particularly alarming is what is actually at stake. For all its flaws, the EU remains one of the world’s most consequential projects built around liberal democracy, the rule of law, individual freedoms and cooperation between nations. At a time when authoritarianism is gaining ground and even longstanding democracies are showing disturbing tendencies, that matters enormously. Europe is far from perfect. Its bureaucracy, indecision and inability to act decisively are real problems. But the answer cannot be to retreat into 27 competing nation-states, each too small to meaningfully influence a world increasingly dominated by continental powers. Quite the opposite. Europe needs deeper integration, stronger common institutions, genuine strategic autonomy and the political courage to defend its interests and values. Because fragmentation is precisely what so many external actors want. And perhaps that’s the central irony of our time: people are being deliberately manipulated into believing that the reverse is true — that national identity and sovereignty can only be protected by weakening European cooperation. In reality, a divided Europe is less sovereign, less secure and far easier for outside powers to pressure. Therefore the very thing that will make Europe stronger is the thing its adversaries are working hardest to prevent. A united Europe is a geopolitical power. A divided Europe is a collection of countries waiting to be played against one another.
5
3
95
10,070
Celebrating 20 years of iPSC research! 🧫✨ Join us in honoring two decades of induced pluripotent stem cell progress and the researchers advancing the field. Attending #ISSCR’s iPSC 20th Anniversary Symposium in Kyoto? Come celebrate with us! Not attending? Explore key milestones and see where human iPSC research is heading next: bit.ly/4yL9DXz
3
1
11
657
Great news for pulmonary fibrosis patients, families, researchers, clinicians. @bmsnews announces that in phase 3 RCT ( peer reviewed yet), Amilparant, an inhibitor of the LPA receptor, has met primary endpoint! Wow!!! #CurePF4All #BeLikeAndy news.bms.com/news/corporate-…
2
5
26
1,704
John De Vos retweeted
🌐 AI for science just became science diplomacy. On October 4, the US and 16 other countries, including Japan, South Korea, the UK, Germany and Singapore, endorsed the "Kyoto Vision for a Golden Age of Science" at the STS Forum in Kyoto. I only learned about it today, from a friend. In case you missed it too, here is the short version. 💡 The one-page text covers a lot of what I care about. More diverse funding, from long-term awards to fast grants and prizes. Room for new institutional models. Metascience and reproducibility. AI for science, including autonomous closed-loop discovery. Early investment in young talent. Much of this I support. Closed-loop, AI-driven experimentation is at the core of what we do in the Theis lab, and funding systems everywhere could use more experimentation themselves. The declaration builds on the White House report "Science: A New Golden Age" from July, which goes further, for example in rethinking the role of universities. Not trivial. How these ideas translate will differ between national systems. Germany's research ministry, for instance, calls the paper a non-binding basis for discussion and stresses that freedom of research and the independence of science remain non-negotiable. 🌍 For me, the test will be concrete: shared access to compute, data and automated labs, and collaboration across borders. Researchers should help shape what this means in practice. How do you see it? Will it change how science is funded where you work? 🇩🇪 BMFTR statement: bmftr.bund.de/SharedDocs/Kur… 📄 Kyoto Vision: bmftr.bund.de/SharedDocs/Dow… 📘 Science: A New Golden Age: whitehouse.gov/wp-content/up… 🇺🇸 White House release: whitehouse.gov/releases/2026… #AIforScience #ScienceDiplomacy #Metascience
5
10
1
79
8,679
John De Vos retweeted
How much do PhD students earn? The first comprehensive overview of PhD income shows vast imbalances across much of Europe Read the full story: nature.com/articles/d41586-0…
47
375
74
1,340
239,412
Similarly, Cellectis is shifting its focus from ex vivo allogeneic #CART cells therapies to in vivo CAR-T approaches. fiercebiotech.com/biotech/ce…
1
112
Recent safety events with Novartis and BMS highlight the challenge of translating #CART from life-threatening cancers to chronic autoimmune diseases Meanwhile, Kyverna’s miv-cel continues to show encouraging efficacy and safety in stiff person syndrome biospace.com/drug-developmen…
2
2
164
John De Vos retweeted
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
436
9,108
1,615
24,071
3,977,763
Century Therapeutics’ Allo-Evasion™ 5.0-edited CNTY-813 (#iPSC-derived islets) showed durable glycemic control in diabetic animal and clinical-scale manufacturing. IND submission planned for Q4 2026, with first clinical data expected in 2H 2027. markets.businessinsider.com/…
1
2
97