PhD Student in Systems Immunology @Dunn_School, amateur @Wikipedia writer
Oxford, England
Joined June 2016
- Tweets213
- Following213
- Followers170
- Likes454
Anna Huhn retweeted
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
biorxiv.org/content/10.1101/…
Anna Huhn retweeted
I am excited to share the results from my PhD project at the @Dushek lab and my first first-author manuscript!
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors.
biorxiv.org/content/10.1101/…
🧵
Anna Huhn retweeted
Very excited about CellOT, developed by @_bunnech in Andreas Krause's lab @ETH_en, Stefan Stark in @gxr lab and @GabriGut in my lab, that allows us to link single cells between conditions. Works particularly well with 4i multiplexed imaging data.
nature.com/articles/s41592-0…
In order to understand why antibodies are so good at neutralising pathogens, you have to understand their bivalent binding properties.
Here we predict - for the first time - antibody potency solely from their binding parameters.
Happy to see our work published on bioRxiv today!
Antibodies are bivalent molecules but we study/optimise them based on their monovalent binding.
New work provides a simple method to analyse & predict bivalent binding!
The molecular reach of antibodies determines their SARS-CoV-2 neutralisation potency biorxiv.org/content/10.1101/…
Anna Huhn retweeted
Antibodies are bivalent molecules but we study/optimise them based on their monovalent binding.
New work provides a simple method to analyse & predict bivalent binding!
The molecular reach of antibodies determines their SARS-CoV-2 neutralisation potency biorxiv.org/content/10.1101/…
Anna Huhn retweeted
Our new work!
Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to investigate the sensitivity and costimulatory requirements of TCRs and CARs
biorxiv.org/content/10.1101/…
Anna Huhn retweeted
Our latest work showing that higher-affinity TCR/pMHC interactions display stronger slip bonds compared to lower-affinity interactions that display weak slip bonds or catch bonds. Thus, force makes different antigens look similar to T cells.
Mechanical forces impair antigen discrimination by reducing differences in T-cell receptor/peptide–MHC off-rates
@vdmerwex @Dushek @Dunn_School Philippe Robert @univamu et al
embopress.org/doi/full/10.15…
Check out my poster (No.28) at #londoninfectimmun – An algorithm to measure antibody bivalent binding parameters and predict neutralisation potencies, applied to SARS-CoV 2 nAbs
Anna Huhn retweeted
Out now 🥳 Bottom-up assembly of synthetic immune cells that can identify and kill cancer cells
sciencedirect.com/science/ar…
Great work by the whole team @mpi_mr_hd @mattertolife @MSE_UNIHD @MaxPlanckBris
Anna Huhn retweeted
Unser Wissenschaftssystem ist seit Langem krank und braucht dringend eine Generalüberholung. Obwohl seit über 2 Jahren gefühlt täglich über Wissenschaft geredet wird, hat kaum jemand die leiseste Ahnung, was in den Laboren und Bibs dieses Landes so alles abgeht.
Anna Huhn retweeted
Our recently completed work:
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.
biorxiv.org/content/10.1101/…
Anna Huhn retweeted
Our work quantifying the discriminatory power of T cells is now published in @eLife with a great press release:
Immune cells imperfect at distinguishing between friend and foe, study suggests elifesciences.org/for-the-pr…
If you are not aware of this yet: Everyone in the UK can now get a free rapid lateral flow test to get tested twice a week against COVID. Place your order here: gov.uk/order-coronavirus-rap…
Anna Huhn retweeted
Auf vielfachen Wunsch, hier einmal eine Übersicht über einige meiner „Erklär-Tweets“ als 📌 angehefteter Thread! Einfach durchblättern und stöbern, vielleicht ist ja was Interessantes dabei. 📚 🧑🔬
1️⃣
Den Anfang macht dieser allgemeine Thread zum #SARSCoV2-Nachweis im Labor:
1/ Viele Diskussionen um #SARSCoV2 / #COVID19 sind recht abstrakt und drehen sich v.a. um Infektionsrouten und die Epidemiologie. Außerdem immer wieder die Frage „Könnt ihr das #Coronavirus überhaupt nachweisen, oder nur ‘Genschnipsel‘ mit der ‘Drosten-PCR’?“ Hier ein paar Infos!
Anna Huhn retweeted
@richardneher Interview zur neuen #coronavirus Variante und Erkenntnisse aus @nextstrain:
spiegel.de/wissenschaft/medi…
Lockdown is a good time to revisit old literature and to check if the results we built our theories on are actually true. Turns out 𝘵𝘩𝘦𝘺 𝘢𝘳𝘦 𝘯𝘰𝘵 in the case of antigen discrimination by the T-cell receptor
biorxiv.org/content/10.1101/…
Anna Huhn retweeted
Wichtiges #maiLab Video mit möglichen Corona-Szenarien, die jeder kennen sollte: youtu.be/3z0gnXgK8Do
Wer sich noch nicht den Coronavirus Podcast vom @ndr mit Christan Drosten @c_drosten anhört, sollte schleunigst damit anfangen. ndr.de/nachrichten/info/podc…
Anna Huhn retweeted
NEW: the Thursday 19 March update of our coronavirus mortality trajectories tracker
• Italy now has more Covid-19 deaths than China’s total
• UK remains on a steeper mortality curve than Italy, while Britain remains far from lockdown
Live version here: ft.com/content/a26fbf7e-48f8…
This is a very informative video about #COVID19 and a great example of good scientific communication
