Protein expression guru, dabbler in drug discovery. professional golfer and poker player in my dreams
Middletown, MD
Joined May 2010
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Dominic Esposito retweeted
A collaboration between the RAS Initiative @FredNatLab, @Livermore_Lab and @BridgeBioPharma resulted in the discovery of BBO-8520, which has recently cleared @US_FDA's investigational new drug application. Explore the impact of BBO-8520 on mutant cancers: livermorelab.info/47lg05w
McClintock's seminal work set the stage for the use of transposons as molecular biology tools as well. Transposition technology is the key to simple modification of baculovirus genomes to permit high-level production of recombinant proteins in insect cells. #TransposonDay2023
Happy Transposon Day 2023! Today is the 121st birthday of Barbara McClintock, founder of the #transposon field and Nobel laureate. Please celebrate with us by using the hashtag #TransposonDay2023. How has Barbara McClintock or her work influenced you? mobilednajournal.biomedcentr…
Well done to my colleagues Carissa Grose and @G33KMatt as well as the other FNLCR LDER recipients! Looking forward to some innovative science that will help improve our ability to produce recombinant proteins in the baculovirus-based insect cell system!
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It's an inarguable fact that T.S. Eliot's The Waste Land is the greatest poem ever written. However, @petridishes feline version in her new book somehow manages to improve the original masterpiece! Jug jug jug Tereu Miaou indeed... 😂
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Anyway, whether you agree with me about Eliot or are just wrong, you should definitely buy this book! amazon.com/Alexandra-Petris-…
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My colleague @simanshu is indeed amazing, although I think @AACR has given him an honorary MD degree in this Tweet 😀. Great to see him and many of my other @FredNatLab RAS Initiative colleagues presenting their awesome data at this meeting.
Dhirendra K. @Simanshu, BSc, MSc, MD, PhD, of @FredNatLab answers a question from the audience during his presentation on "Opening new structural insights into RAS interactions with effectors and regulators" at the opening plenary at #AACRras23.
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Well deserved aware to @kevansf, who basically paved the way for every KRAS drug discovery effort in the last decade and demonstrated that the "undruggable" could actually be drugged.
This year’s Sjöberg Prize is awarded to professor Kevan Shokat, @UofCalifornia, for a huge scientific breakthrough that is bringing hope to people who are critically ill with lung cancer.
kva.se/en/news/sjoberg-laure…
@UCSFCancer @UCBerkeley @UCSF @kevansf
#Sjöbergprize
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New work from our team at @FredNatLab and @UCSFCancer identifies the mechanism of severe disease mutations in neurofibromatosis type I through a combination of biochemical and structural analysis. #NF1
pnas.org/doi/10.1073/pnas.22…
Given the large number of helical bundles in the structure of neurofibromin, these results suggest a potential foundational mechanism for destabilization of neurofibromin in a variety of point mutants and should help predict genotype-phenotype correlations in NF1 disease
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A great collaborative effort with Lucy Young, Ruby Goldstein de Salazar, and others in the @frankpmccormick lab, @vanessa_vewall @G33KMatt in my group, and Alan Merk, Joe Darling, and Jana Ognjenovic in the @FredNatLab National Cryo-EM Program
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Great work by my colleagues at @theNCI and @FredNatLab to explore the impact of mutations found in RASopathy diseases. And as always, @ATUM_bio synthetic genes make things so much easier...
BRAF is part of the anti-apoptotic RAS-ERK MAPK pathway and is often mutated in human cancer. @theNCI @LeidosInc use constructs from @ATUM_bio to show how BRAF mutations affect phosphatidylserine binding and RAS-RAF interaction for activation cancer cells pubmed.ncbi.nlm.nih.gov/3634…
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@petshopboys and @neworder at @MerriweatherPP about to start. Been waiting a whole pandemic for this to be rescheduled!
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Glad our team at @FredNatLab could play a small role in this excellent work—another great example of collaborative NIH science helping to fight the pandemic over the last 18 months.
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I love it @cispt2! Definitely the goal of all of us working on RAS therapeutics!
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Another success for rational structure-based vaccine design from the hands of @McLellan_Lab and colleagues at NIH. For once maybe viruses will start living in fear of us…
Received an email from Rino Rappuoli this morning informing me, @BarneyGrahamMD and Peter Kwong of the positive phase III data for the RSV prefusion F vaccine results in older adults. It's been almost 10 years since we designed the first prefusion RSV F antigen, DS-Cav1. Amazing!
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