Emily Kaye (@egkaye) header
Emily Kaye (@egkaye) profile picture

Emily Kaye

@egkaye

Postdoctoral research: @Adelmanlab Graduate school research: @EricaLarschan

 Cambridge, MA
Joined February 2011
  • Tweets78
  • Following156
  • Followers106
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Photo by Emily Kaye (@egkaye)Photo by Emily Kaye (@egkaye)Photo by Emily Kaye (@egkaye)Photo by Emily Kaye (@egkaye)Photo by Emily Kaye (@egkaye)Photo by Emily Kaye (@egkaye)Photo by Emily Kaye (@egkaye)
I’m excited to share that I’m starting a new position as a Yale School of Medicine Science Fellow in the Department of Genetics @YaleGenetics! I’ll be co-mentored by the Reinke and @Noonanlab Labs. Can’t wait to join the scientific community at Yale this Sept! @YaleSciFellows
Image from Claudia Mimoso (@camimoso)
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Emily Kaye retweeted
Ben Martin (@bmart87) profile picture
Ben Martin@bmart8711 Aug 2024
I am so excited to share that I am starting this Fall as an Investigator at @LDI_ILD and Assistant Professor at McGill @McgillGBDO! I’ll be recruiting students and a research asssistant- Get in touch if you’re interested in chromatin and gene regulation! martinlab.ca

Martin Lab | Ben Martin

The lab of Ben Martin located at the Lady Davis Research Institute in the Gerald Bronfman Department of Oncology, McGill University.

martinlab.ca
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A spatiotemporal map of co-receptor signaling networks underlying B cell activation dlvr.it/T7ynrF
A spatiotemporal map of co-receptor signaling networks underlying B cell activation

A spatiotemporal map of co-receptor signaling networks underlying B cell activation

Susa et al. develop an unbiased, cell-based system to profile the proteins recruited to the B cell co-receptor, CD19, throughout B cell activation. The recruitment dynamics of known and previously...

cell.com
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I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to @BlacklowLab and @AdelmanLab and all co-authors! biorxiv.org/content/10.1101/…
Notch induces transcription by stimulating release of paused RNA Pol II without increasing chroma...

Notch induces transcription by stimulating release of paused RNA Pol II without increasing chroma...

Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that influences a wide range of cellular processes by regulating transcription. Despite years of study, however, how...

biorxiv.org
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NELF Pausing ⏸️ In my opinion, one of the high ROI directions in transcription field. Beautiful paper from @egkaye and @AdelmanLab showing importance of nelf pausing in spermatogenesis... – at Zurich, Switzerland
Emily Kaye (@egkaye) profile pictureEmily Kaye@egkaye30 Jan 2024
Happy to announce the final version of our paper is now available @NatureComms! nature.com/articles/s41467-0… Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!
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Happy to announce the final version of our paper is now available @NatureComms! nature.com/articles/s41467-0… Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!
Emily Kaye (@egkaye) profile pictureEmily Kaye@egkaye10 May 2023
I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors @hdzomer @geoffmnelson @AdelmanLab, Irene, Debarun, and Prabu!!
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I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors @hdzomer @geoffmnelson @AdelmanLab, Irene, Debarun, and Prabu!!
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint10 May 2023
RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis biorxiv.org/cgi/content/shor… #bioRxiv
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Congratulations to @camimoso and @AdelmanLab on an impressive investigation into RNA Pol II elongation!!
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell24 Mar 2023
Online Now: U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes dlvr.it/SlQPQQ
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🚨For my brand new lab in Utrecht (@UUBeta), I'm recruiting a Research Technician for 8 months! 🚨 Find more info here: tinyurl.com/2cu2kszd I deeply care about the development and success of the people in my lab, and think this can be a great training opportunity.
Vlaming group vacancy research technician.pdf

Vlaming group vacancy research technician.pdf

Shared with Dropbox

dropbox.com
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Excited to share the last part of my PhD work, where we track co-receptor signaling dynamics during B cell activation! Great collaboration with @KalocsayMarian biorxiv.org/content/10.1101/…
A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation

A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation

The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. This process underlies nearly every aspect of...

biorxiv.org
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Emily Kaye retweeted
Ben Martin (@bmart87) profile picture
Ben Martin@bmart878 Mar 2023
So excited to see my postdoc work out in the world! Here we show that EP400/TIP60 can broadly compensate for loss of SWI/SNF activity at promoters. See below for a short(ish) thread on our work (1/X): biorxiv.org/content/10.1101/…
Image from Ben Martin (@bmart87)
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Check out this exciting new paper we contributed to that provides the first single cell time course of early fly embryogenesis: science.org/doi/10.1126/scie…
The continuum of Drosophila embryonic development at single-cell resolution

The continuum of Drosophila embryonic development at single-cell resolution

A single-cell atlas of chromatin accessibility and gene expression reveals cell lineages and gene expression patterns during Drosophila embryogenesis.

science.org
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Congratulations DR Eileen Ablondi, on a fantastic thesis defense today! I am so proud of what you have accomplished, and excited for your next steps! @BBS_Harvard @HMS_BCMP
Image from AdelmanLab (@AdelmanLab)
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Congrats to @LucasFarnung and @filipovskim_ !!
Lucas Farnung (@LucasFarnung) profile pictureLucas Farnung@LucasFarnung16 Jun 2022
🔥Here’s the first publication from the Farnung Lab!🔥 We reveal the structural basis of nucleosome retention during transcription by capturing a novel transcription-chromatin intermediate by cryo-EM. ⬇️ science.org/doi/10.1126/scie… Phenomenal work by Martin Filipovski!
Image from Lucas Farnung (@LucasFarnung)
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Now out in @NatureSMB: my paper on the sequence determinants of RNAPII elongation potential! I'm so happy to see it in its final form! 🤩 Find it here: nature.com/articles/s41594-0… Or view with this link, if you don't have a subscription: rdcu.be/cPjTJ

Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of...

Nature Structural & Molecular Biology - Here the authors present the INSERT-seq methodology to investigate the effect of transcribed sequence on processive transcription. The authors find that...

nature.com
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Emily Kaye retweeted
IMP (@IMPvienna) profile picture
IMP@IMPvienna1 Jun 2022
The @stark_lab is on a streak! In their latest paper now published in @Nature, they present the first functional categorisation of enhancers based on their #cofactor dependencies. (1/3) ⬇️ nature.com/articles/s41586-0…
Differential cofactor dependencies define distinct types of human enhancers

Differential cofactor dependencies define distinct types of human enhancers

Nature - The systematic categorization of human enhancers by their cofactor dependencies provides a conceptual framework to understand the sequence and chromatin diversity of enhancers and their...

nature.com
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Emily Kaye retweeted
AdelmanLab (@AdelmanLab) profile picture
AdelmanLab@AdelmanLab7 Mar 2022
Anyone interested in learning more about gene regulation and epigenetics should consider applying!
CSHL Courses (@cshlcourses) profile pictureCSHL Courses@cshlcourses7 Mar 2022
Call for @cshlgnx applications--due 4/1! Chromatin, Epigenetics and Gene Expression (July 26-August 14) Instructors: @AdelmanLab, @ChromaTownie and @MarcMendillo Free to apply; Financial aid available For course info and COVID-related policies: bit.ly/gnx22
Image from CSHL Courses (@cshlcourses)
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I am excited to share this new paper I contributed to! This was a collaborative effort investigating the protective role of m6A methylation against nascent RNA cleavage by the Integrator complex. Congrats to Yang Shi, Hongjie Shen, @AdelmanLab, @geoffmnelson and other co-authors!
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell25 Feb 2022
Online Now: Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis dlvr.it/SKg2yv
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

Xu et al. show that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) widely localizes to promoters and enhancers and deposits the m6A modification on nascent transcripts. Further, they...

cell.com
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Congrats to my amazing friend and colleague @juliamr418 on her grant!!!
American Society for Cell Biology (@ASCBiology) profile pictureAmerican Society for Cell Biology@ASCBiology28 Jan 2022
ASCB welcomes our 2022 cohort of MOSAIC scholars: Elizabeth Duran @UMich Julia Maria Rogers @harvardmed Lomeli Shull @CUAnschutz We can't wait to see what you do! ow.ly/bhql50HG1wp

MOSAIC AMP 2022 Cohort - ASCB

Adelita D. Mendoza, Ph.D. Project Title: Regulation of Zinc-Dependent Lysosome Morphological Restructuring, Zinc Trafficking, and Low Zinc Homeostasis in C. elegans and Human Model Systems Washington...

ascb.org
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ASCB welcomes our 2022 cohort of MOSAIC scholars: Elizabeth Duran @UMich Julia Maria Rogers @harvardmed Lomeli Shull @CUAnschutz We can't wait to see what you do! ow.ly/bhql50HG1wp

MOSAIC AMP 2022 Cohort - ASCB

Adelita D. Mendoza, Ph.D. Project Title: Regulation of Zinc-Dependent Lysosome Morphological Restructuring, Zinc Trafficking, and Low Zinc Homeostasis in C. elegans and Human Model Systems Washington...

ascb.org
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