Harsh (@harsh1) header
Harsh (@harsh1) profile picture

managing partner @wireframevc|ex: founder, engineer, natsec investor|husband & father|india ‣ chicago ‣ sf

🌎
Joined May 2008
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Harsh retweeted
Patients cannot wait another day for tomorrow’s medicines. Today, bringing a drug to market can take more than 10 years and cost over $1 billion. A major contributor is the time and expense required to generate and review the documentation that helps to build medicines that are safe and effective. That is why we are thrilled to partner with @AnthropicAI to transform drug development, starting with our clinical-stage programs. Together, we built tools to address two major early-stage bottlenecks: preparing a complete IND package and reviewing CMC batch records for release. The results have been groundbreaking in speed, cost, and quality. Read more: anthropic.com/research/early…
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I started @enveda so mothers could fight their diagnoses with power mine never had. Sept 18 is her birthday. It’s also the day our first IND cleared, our first patient data came in, and now our Series E closed. More backup for the fight ahead. Happy Birthday, Mom!
Today we are announcing a $311M Series E to bring pharma into the 21st century. Enveda started with a thesis: a molecule that evolution has already refined is a better place to begin than one designed from scratch. This year, two first-in-class molecules discovered by Enveda (ENV-294 and ENV-308) had positive readouts in humans. Many more are behind them. We are grateful to @CatalioCapital for leading this round, to our new investors Durable Capital Partners, @ICONIQCapital, @lightspeedvp, Surveyor Capital (a Citadel company), accounts advised by @TRowePrice, @digitalisvc and Alderline Group, and to @BaillieGifford, @PremjiInvest, @trueventures, @KinnevikAB, @FPVventures, @_DimensionCap, @lifeforcecap and @Lux_Capital for continuing to back us. The best is yet to come… Read more: businesswire.com/news/home/2… #Biotech #AI #LearningfromLife
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Today, after about a year and a half of heads-down work, I’m excited to announce that Arcturus is emerging from stealth with an $8M seed round led by Initialized Capital with participation from 1517, Toyota Ventures, Wireframe Ventures, and Climate Capital. This all started with a realization that I couldn’t shake: the world’s asking more and more from metals that were never designed for the systems we’re building today. EVs, drones, robotics, AI data centers, the grid. The modern world runs on copper and aluminum doing their job quietly in the background. But as power, heat, and performance demands keep rising, those materials are becoming a bottleneck. At Arcturus, we’re building a new class of conductor materials by infusing carbon nanomaterials into metals. The goal is simple: help wires, motors, and thermal systems move more power, shed more heat, and hold up in harsher conditions, without redesigning everything around them. Not long ago, this was just an idea in my garage in Los Angeles. I’m incredibly grateful to our investors, partners, advisors, and early believers who helped us get here: thank you for seeing it before there was much to see. This is just the beginning and I’m so excited for what comes next! @Initialized @zcperret @brettdg | @1517fund @William_Blake @DStrachman | @Breakthrough @bchevva | @WireframeVC @lbernicker @harsh1 | @Toyota_Ventures @lisabcoca | @climatecap @sunrock | @smathaudhu | @al_mashal @april_brady @SarahRhoades @arcturustechinc
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Introducing @tembo The unified interface for background coding agents.
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Proud to work with @DaneshSamy & @theCyrusJia to bring Argon AI's vision to life. Their AI intelligence platform helps biopharma teams make smarter, faster decisions – accelerating time-to-market for life-changing medicines.
Exciting milestone for Argon AI—we’ve raised a $5.5 million seed round led by @CrosslinkCap and @WireframeVC , with support from @ycombinator , @pioneer_fund , and industry operators. Grateful to our customers for their trust and our investors @ThePhilBoyer, @harsh1, @DaveMessina, @SurbhiSarnaSF and countless others for believing in Argon's vision. We believe AI will fundamentally reshape how biopharma companies and life science consultancies operate. Argon's mission is to give biopharma & life science consulting teams an AI-native workspace that turns scattered data into decision-ready insights in minutes—not weeks. Early partners are already elevating their teams away from the data-drudgery that plagues the industry towards higher-order tasks — science, strategy, and domain specific taste and intent. This capital lets us accelerate building new products and features to delight our partners. And huge kudos to the Argon team—your speed and grit make the impossible routine! Onward!
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Harsh retweeted
Why we are here... At Enveda, we’re unlocking the secrets of life’s chemistry and harnessing billions of years of evolution to bring #hope to those we love. We are proud to tell our story in #TheNextFrontier, a global series presented by the @Biotechnology Innovation Organization and produced by @BBCStoryWorks Commercial Productions. Together with world-renowned biochemist and bestselling author Nick Lane, as well as leading metabolomics researcher, Pieter Dorrestein, we delve into how nature, one of the most powerful yet unexplored sources of medicine, is helping us understand the molecular basis of life and guiding us to develop groundbreaking treatments for today’s most urgent health challenges. Watch here: bbc.com/storyworks/the-next-… Catch the live launch at #BIO2025 in Boston: June 18 | AM ET| Storytelling Stage – and a discussion with our CXO Dan Wee, PhD at AM ET. What breakthroughs are you hoping are hidden in life’s chemistry?
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Harsh retweeted
Looking for cracked entrepreneurial devs to join us in building the world's first "Async AI Software Engineer" DMs open :)
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Climate resilience is a new market being built in real time. At our #SFClimateWeek2025 panel on Engineering Global Resilience, leaders from Google, Gridware, Understory & Nephila shared challenges & new tech approaches to managing climate risk 👇 wireframevc.com/community/sf…
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Any new founder in techbio / platform bio should read this from Ankit. Clear insights for this category that you should fully appreciate before you start.
With the start of my first batch as a visiting partner at @ycombinator, this felt like a good time to write my founder story about our journey at @reverielabs. It's a bit of a long one. ankitg.me/blog/2025/01/06/un…
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Why I'm so excited to have @lbernicker as a partner. She's been an incredible addition to our team, and this is just the beginning.
We are thrilled to announce the promotion of Lily Bernicker to Partner at Wireframe Ventures 🌟 Read more about her journey and why we’re so proud to have Lily on our team wireframevc.com/community/li…
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5 years from pre-seed to clinical stage is unreal execution from this team - and so much more to come 👏🏽
Today the emotions are many but words are few. I’ll save the latter for a longer post soon. Let’s go @enveda ! 🚀
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We’ve been enthusiastic supporters of Bruce Beutel & Passkey Therapeutics since their pre-seed round. Read why we were excited to back this team & their pioneering approach to unlocking complex disease biology through a new class of multifunctional drugs🧬wireframevc.com/community/wh…
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We’re excited to publish @WireframeVC’s inaugural Impact Report, showcasing the incredible work our portfolio companies are doing to tackle critical challenges in climate and health. Full report here: docsend.com/view/xvjpukdn3yi…
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I couldn't be more proud of @HeidiPatelSF and the incredible work she's done building @rethinkimpact from an idea into such an important platform at scale ❤️ forbes.com/sites/maggiemcgra…
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We’re excited to lead an investment in Cocoon, supporting their mission to decarbonize the concrete & steel industries (producing 14% of global GHG emissions). Read why we were so compelled by this team & their approach to industrial decarbonization wireframevc.com/community/wh…
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Check out some of the latest TechBio & Health job openings across @WireframeVC's Portfolio⚕️🧬👇
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I was fortunate to work with @rywalker as he built @astronomerio into the leading COSS Airflow company, and super excited to back him again as @tembo_io aims to be the all-in-one platform for Postgres 🐘
Exciting day today in my next “you can’t start a company like that in the Midwest” journey, @tembo_io raises Series A, backed once again by the absolute greatest VC firms. tembo.io/blog/series-a 🔥 we are fired up to execute from here 🔥
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Will AI & Electrification break the grid? We convened a thought-provoking panel discussion @SFClimateWeek to explore this critical topic & share insights on how climate founders can respond 🔌⚡️ Read more: wireframevc.com/community/sf…
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