Used to move water (with impurities) from one container to another, now @MenloVentures.
Joined July 2009
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Crowding on targets seems like a capital allocation issue rather than an AI issue. Yes it'll happen but plenty of companies working on new targets both because the molecular generation is being deployed for hard targets and AI is being used to help generate new ideas.
The Fruits of AI Drug Abundance: Indigestion In The Near Term
While the long term impact of AI is likely transformational, in the near term more drugs against known targets will likely exacerbate the crowding challenge dragging down industry R&D productivity
lifescivc.com/2026/10/the-fr…
Love reading about these projects that would have taken entire PhDs to do previously. We're going to see a lot more elegant, self-contained solutions like this in the coming months...
What will drug discovery look like when intelligence is abundant?
Our team at @generate_biomed began with this question, and we’re excited to share some results!
We took on in vivo CAR-T and designed a scaffold 70% smaller than ones in the clinic, with 3x the potency 🧵
Johnny Hu retweeted
Congratulations to Xaira Therapeutics on the successful launch of its innovative biotech which leverages AI to better understand biological systems and develop new therapeutic approaches.
We're entering an era of tremendous innovation and progress in the biotech space, and we're thrilled to partner with Xaira via @grgyap and @hu_j.
endpts.com/in-biggest-ever-b…
Johnny Hu retweeted
Liu lab #xCas9 plasmids are finally available @Addgene - and that means my blog post about them is too! Thanks @hu_j and @TyFordFever for help with editing! #CRISPR hubs.ly/H0bvgry0
Johnny Hu retweeted
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity fal.cn/4smf via @nature #CRISPR
xCas9 is the flavor of the week. Excited to see what's next on the docket. #cas9 #geneediting nitter.cf/NewsfromScience/status…
From telescopes to caterpillars, this week's top stories in science: scim.ag/2CU30Wb
Johnny Hu retweeted
Researchers have evolved new variants of #CRISPR-Cas9 that are compatible with a wider range of required bases, opening access to more regions of the genome fal.cn/4i_t
Our xCas9 work was just highlighted by Nature Biotech. We evolved broader PAM compatibility and higher specificity in one protein. nitter.cf/NatureBiotech/status/9…
Genome editing: new Cas9 variants recognize a very broad range of PAM sequences and exceeds wt spCas9 in specificity go.nature.com/2HVWylc #NBThighlight
Our latest project on evolving Cas9. nature.com/articles/nature26… nitter.cf/NatureNews/status/9689…
