Simon Newstead (@inwardopen) header
Simon Newstead (@inwardopen) profile picture

Simon Newstead

@inwardopen

David Phillips Chair of Molecular Biophysics

 University of Oxford, UK
newsteadgroup.org
Joined April 2016
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Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)Photo by Simon Newstead (@inwardopen)
We are delighted to welcome Professor Helen Cooper to the Franklin. Helen plans to establish a core capability in native ambient mass spectrometry at the Franklin, pairing these methods with other transformative technologies. Read more here: zurl.co/ASYj5
A photo of Professor Helen Cooper besides the quote "I’m particularly excited about integrating mass spectrometry with cryo-EM and cryo-ET. The complementarity of these techniques can open new doors in structural biology"

ALT A photo of Professor Helen Cooper besides the quote "I’m particularly excited about integrating mass spectrometry with cryo-EM and cryo-ET. The complementarity of these techniques can open new doors in structural biology"

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#MeetTheLab Introducing the Higgins Lab at @BiochemOxford this week! Led by #KavliOxford Prof. Matt Higgins, the group studies how parasites invade, acquire nutrients, and evade immunity—guiding better vaccine design. #ParasiteBiology #VaccineResearch
Image from Kavli Institute for Nanoscience Discovery, Oxford (@KavliOxford)
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Simon Newstead retweeted
Rob Klose (@RobKlose) profile picture
Rob Klose@RobKlose14 Oct 2024
Want to do a DPhil @BiochemOxford ? Here is a link (bioch.ox.ac.uk/graduate-abou…) to programmes that admit students. Great labs to choose from. Have a look at kloselab.co.uk if you want to know more what we do in my group! Please RT!
Image from Rob Klose (@RobKlose)
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Latest preprint from the group has landed - Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter. biorxiv.org/content/10.1101/… A great team effort involving researchers from around the world! @LeaLabTweets @wellcometrust
Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter

Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy[1][1]. They are implicated in multiple neurological disorders including stroke,...

biorxiv.org
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Super collaboration with the Bennett group in the clinical neuroscience department, including @MiddletonSJ_ @NDCNOxford @BiochemOxford @KavliOxford
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Timed nicely with papers from @RESOLUTE_IMI and @XiaoyangSu who also found SLC45A4 is a polyamine transporter! biorxiv.org/content/10.1101/… & biorxiv.org/content/10.1101/…
SLC45A4 encodes a mitochondrial putrescine transporter that promotes GABA de novo synthesis

SLC45A4 encodes a mitochondrial putrescine transporter that promotes GABA de novo synthesis

Solute carriers (SLC) are membrane proteins that facilitate the transportation of ions and metabolites across either the plasma membrane or the membrane of intracellular organelles. With more than...

biorxiv.org
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Meeting alert - Biological Structures Group Winter meeting 2024 will be hosted by @Carter_Lab at the MRC LMB on December 6th! We have a fantastic line up of speakers and opportunities for poster presentations. @BiochemOxford @KavliOxford
Image from Simon Newstead (@inwardopen)
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Congratulations to our new Dr Löbel! @BiochemOxford @KavliOxford thanks to Paul @Elliott_Lab_Ox and David Drew
Image from Simon Newstead (@inwardopen)
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Simon Newstead retweeted
Lori Passmore (@lapassmore) profile picture
Lori Passmore@lapassmore31 Jul 2024
New work from @palconh in my group shows that DNA repair proteins FANCD2-FANCI slide on double-stranded DNA. Surprisingly they specifically recognise single-stranded junctions #cryoEM Our first foray into single molecule imaging thanks to @RuedaLab @MRC_LMB @MRC_LMS Thread here:
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Out just now in @eLife: MD simulations combined with transport assays to study energy and substrate coupling in the mechanism of the mammalian peptide transporter PepT2. Work with Jo Parker, @inwardopen and @philbiggin . doi.org/10.7554/eLife.96507.…
The mechanism of mammalian proton-coupled peptide transporters

The mechanism of mammalian proton-coupled peptide transporters

The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.

elifesciences.org
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Stay tuned for more exciting insights into this fascinating chimera of trafficking receptor and Solute Carrier!
Structure (@Structure_CP) profile pictureStructure@Structure_CP12 Jul 2024
Molecular basis for pH sensing in the KDEL trafficking receptor dlvr.it/T9WSZ8
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Really excited to be here at the 2024 structural biology meeting at Tsinghua University, with Prof Yigong Shi kicking off the meeting.
Image from Simon Newstead (@inwardopen)
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Interested in Solute Carrier structural biology & Drug Design? Come join our fantastic team here in Oxford @philbiggin @BiochemOxford @KavliOxford bioch.ox.ac.uk/jobs

Job opportunities

bioch.ox.ac.uk
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Simon Newstead retweeted
Matt Higgins (@ParasiteMatt) profile picture
Matt Higgins@ParasiteMatt7 Jul 2024
This is so concerning. Nothing against the humanities. But most of the great challenges facing humanity - climate change, energy, health care (physical and mental), pandemics, biodiversity loss - cannot not be solved without science and technology. Where are the scientists?
Image from Matt Higgins (@ParasiteMatt)
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Our latest paper on Extracellular modulation of TREK2 K2P channels by nanobodies is now finally online in @NatureComms nature.com/articles/s41467-0…
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of...

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of...

Nature Communications - K2P channels are important regulators of cellular electrical activity. Here the authors show how nanobody fragments can be used to detect and modulate TREK2 K2P channel...

nature.com
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Simon Newstead retweeted
Hite Lab (@HiteLabMSKCC) profile picture
Hite Lab@HiteLabMSKCC3 May 2024
Excited to share our recent study Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1 published this week @Nature led by amazing @Yeeun_Jecy_Son in collaboration with @TimCKenny @ArtemAKhan @KivancBirsoy @MSKCancerCenter nature.com/articles/s41586-0…
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Simon Newstead retweeted
Rob Klose (@RobKlose) profile picture
Rob Klose@RobKlose23 Apr 2024
Come join us in Oxford as an Associate Professor in Molecular and Cellular Biochemistry. We are considering a wide range of research areas, but I would note that we have a vibrant chromatin and gene regulation community. Happy to answer questions if you are interested. Please RT!
Image from Rob Klose (@RobKlose)
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Congratulations to @EllieTzima who was presented with the 2024 GlaxoSmithKline Award at the 90th Harden today! We hope everyone enjoyed her exciting talk on guiding mechanical cues in blood vessels. #BiochemAwards #BiochemEvent
Ellie Tzima pictured holding her award.

ALT Ellie Tzima pictured holding her award.

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Simon Newstead retweeted
Kat Ciazynska (@KatCiazynska) profile picture
Kat Ciazynska@KatCiazynska18 Apr 2024
in case you all like membrane proteins, there's a lot of cool stuff in the fresh-off the press @NatureSMB issue nature.com/nsmb/volumes/31/i…
Image from Kat Ciazynska (@KatCiazynska)
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An exciting time in Solute Carrier research. Here are some of the areas where SLC structural biology is heading and where future opportunities for new discoveries and therapeutic interventions await. rdcu.be/dE759 nature.com/articles/s41594-0… @BiochemOxford @KavliOxford
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