Biophysicist who runs a group @_Hubrecht, into figuring out how our genes are switched on and off in space and time, also biking.
Utrecht, the Netherlands
Joined April 2013
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Jacques Bothma retweeted
How do cells measure time? That is one of the main unanswered questions in developmental biology. New research by the Korswagen group, published in eLife on 15 May 2023, brings us one step closer to the answer. Read more here: hubrecht.eu/roundworm-cellul…
ALT Image of C. elegans roundworm
Ever wonder what regeneration looks like in scRNA-seq data?
You get a ring!!
Caused by cells dynamically de-differentiating, and then re-differentiating again.
This and many other awesome findings on heart regeneration in a story from @J_Bakkers in @ScienceMagazine this week.
Jacques Bothma retweeted
How to repair a damaged heart? The lab of @J_Bakkers studied #zebrafish and identified calcium handling as a key mechanism during #regeneration that decides if a #heart muscle cell divides or matures.
Read more here: hubrecht.eu/how-to-repair-a-…
@ScienceMagazine @CircHealth_umcu
Jacques Bothma retweeted
Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint, we find support for one of the possible mechanisms: transcription factors exchange. A 🧵 1/9. biorxiv.org/content/10.1101/…
Jacques Bothma retweeted
Where transcription begins determines where it ends! Check out our latest study, published today in @CellCellPress. A huge tour de force, led by the extraordinary Carlos Alfonso-Gonzalez @extended_gene doi.org/10.1016/j.cell.2023.… 🧵1/10
Jacques Bothma retweeted
The lab of @jqbothma used single-cell live microscopy to gain new insights on genome regulation during Drosophila development. The results, published in @CurrentBiology, represent a paradigm shift in the prevailing model.
Read more: lnkd.in/ePjwSbyy
#Science #Drosophila
New story form my group on how the activity of different enhancers is choregraphed in time to drive a cell fate decision.
Still much to learn about how the “dark genome” works, but live imaging in the fly embryo is making it possible to shed light on some of its many mysteries!
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Jacques Bothma retweeted
Dramatic results from @wendy_bickmore & co on Shh gene regulation in the limb
Are TADs necessary? Nope
Are CTCF binding sites necessary? Nope
Is physical proximity of enhancer-promoter important? Nope
Do we understand long-range gene regulation? Nope
biorxiv.org/content/10.1101/…
Jacques Bothma retweeted
Joining Twitter to announce our first @BioRxiv paper. Reveals morphogenetic cell behaviors that elongate the #Drosophila follicle –an acinar organ sculpted by ECM stiffness. Very different process than CE. RT please! biorxiv.org/content/early/20…
Jacques Bothma retweeted
Congratulations to @MCB_Cal Prof. & @HHMINEWS Investigator Eva Nogales on receiving the 2019 #GrimwadeMedal !
mcb.berkeley.edu/news-and-ev…
Jacques Bothma retweeted
Reposting explainer of how @homiec17 discovered a mind-controlling zombie fungus that makes lab fruit flies climb, glue themselves in place, raise their wings and fire deadly spore at 20 mph at their friends - out today in @elife elifesciences.org/articles/3…
New paper from my amazing student @homiec17 describing her discovery & characterization of a mind-controlling zombie fungus in wild Drosophila populations - now possible to apply tools of Drosophila genetics and neuroscience to this fascinating phenomenon biorxiv.org/content/biorxiv/…
Jacques Bothma retweeted
Most girls interested in science were directed to teach science in High School, but my Junior High teacher told me, “No, you should become a research scientist!” No amount of bad advice from family, friends and guidance counselors swayed me after her belief in me! – at Seattle, WA
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Jacques Bothma retweeted
I shared my biggest scientific moments working with Maxime when we developed the méthodologies to track single proteins in the nucleus of cells. I will miss him as a friend we will all miss him as a fantastic scientist
.@Institut_Curie is sad to announce that researcher Maxime Dahan, dir. of the physics-chemistry lab passed away. He was a key player in research at the interface between physics & chemistry. It is both a human & scientific loss. Our thoughts go to his family and collaborators
Jacques Bothma retweeted
Even after taking hundreds of such movies it still blows my mind too! Every time i look at a fly now I think about all these little proteins flitting around in every little nucleus in its body regulating gene expression and keeping it alive. nitter.cf/mbeisen/status/1022539…
Jacques Bothma retweeted
For years we've wanted to track single transcription factors molecules in embryos - now thanks to @MustafaMir16 & @michaelrstadler in collaboration w/ @XDarzacq & Melissa Harrison we can do it robustly - and we learn important things about gene regulation biorxiv.org/content/early/20…
Jacques Bothma retweeted
Those of you following @ImpossibleFoods interactions with regulators, @US_FDA just issued a "No Questions" letter (this is good) in response to filing that leghemoglobin (aka plant blood) is GRAS (generally recognized as safe). businessinsider.com/impossib…
Jacques Bothma retweeted
Our first preprint is out. Massive effort from @VictorHeurt and @nickdlowens putting some order in Nanog activity. If you fancy TFs, ES cells and H3K27me3, take a look. Comments are very welcome. nitter.cf/biorxiv_genomic/status…
The molecular logic of Nanog-induced self-renewal biorxiv.org/cgi/content/shor… #biorxiv_genomic
Cool talk by @EloweDevo on how sea squirts get their tails building on classic work of @EvoDevoDiva #2018SDB