Twitter account of the Turner lab at the Francis Crick Institute in London. We study sex chromosomes in health and disease. Rotating curation by lab members.
London, England
Joined November 2018
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🚨Our study uncovering the functions of Y-chromosome genes in male fertility is now out in @ScienceMagazine 🔬🧬
science.org/doi/full/10.1126…
Our latest study is now out! Wonderful summary by the @TheCrick communication team!
Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and affect fertility in male mice. This could eventually help us to understand male infertility.
crick.ac.uk/news-and-reports…
The Turner lab is now on @bluesky ! Follow us there for the latest news from the lab ! 🦋
bsky.app/profile/lab-turner.…
It was a great pleasure for some of us to attend the annual @TheCrick awards🤩! Our very own Ruta was recognised for her involvement in the Laboratory Research Scientist Network Committee.
credit 📷 Michael Bowles
Our latest preprint is out! 🐭🧬We show that sex chromosomes regulate the transcriptional and developmental landscape of the mouse preimplantation embryo.👇⬇️
biorxiv.org/content/10.1101/…
- Sex chromosomes shape gene expression across autosomes during preimplantation.
- The Y chromosome and genes escaping X-inactivation deeply impact the trophectoderm.
- The paternal and maternal X promote embryonic growth differently.
🚨Interested in cutting-edge multi-omics approaches? Curious about how sex chromosomes impact development, health and diseases?🧬 We have an open PhD position at @TheCrick shorturl.at/y4vW8
We are delighted to share our latest preprint led by @JeremieSubrini 🚨
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
biorxiv.org/content/10.1101/…
If you want to chat about the paper or anything sex chromosome related, @JeremieSubrini and James are at the GRS and GRC Mammalian Repro this week!
We would like to thank everyone that has contributed to this study, in particular the amazing STPs at @TheCrick !
We generate a bulk and single nuclei RNAseq atlas of Y-gene KOs, identifying possible underlying molecular mechanisms causing spermatogenic defects. We see an unexpected impact of Y genes on somatic cells of the testis, including Sertoli and the hormone-producing Leydig cells.
We make the equivalent of the human AZFa deletion encompassing Uty, Ddx3y and Usp9y. Unlike in humans, this doesn't cause complete germ cell loss, but we reveal a sperm phenotype absent in single KOs, uncovering a detrimental cumulative effect of Y-gene loss on spermatogenesis.
The transcription activator Zfy2 promotes meiotic pairing and reciprocal recombination between the sex chromosomes.
The histone demethylase Uty functions early in spermatogenesis, regulating the establishment of the spermatogonial stem cell pool and the later spermatogonial differentiation.
While some Y genes are dispensable, others are key for mouse spermatogenesis. We find novel functions for Y genes in spermatogonial, meiotic, post-meiotic and somatic cells.
Our latest preprint led by @sermenchero : opossum single-cell transcriptomics reveals that developmental heterochrony is associated with uncoupling of transcriptional and morphological programmes biorxiv.org/content/10.1101/…
Excited to share our latest work @lab_turner 🚨 Pace of development is often adjusted to gestation time ⏱️So how does the extremely short gestation of marsupials affects their embryo development ? 🐨🦘#DevBio biorxiv.org/content/10.1101/…
A special day for the lab! We are so proud that James was introduced as a fellow of the @royalsociety today! Congratulation again for this amazing achievement 🤩🙌
Turner Lab retweeted
Congratulations to Group Leader James Turner 🥳
James was elected as a Fellow of the @royalsociety in recognition of his contributions to mammalian sex chromosome biology. @lab_turner
crick.ac.uk/news/2023-05-10_…
