Emmanuel Cazottes (@manucazottes) profile picture

Emmanuel Cazottes

@manucazottes

Postdoctoral fellow w/ @CarldeBoerPhD @UBC | PhD w/ @CRougeulle @univ_paris_cite | Roamer of the non-coding genome

Joined January 2021
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  • Followers48
Emmanuel Cazottes retweeted
Dogancan Ozturan (@dogancan) profile picture
Dogancan Ozturan@dogancan8 Dec 2025
I built a a specialized reader for researchers to keep up with the literature. It aggregates papers from 3200+ journals into a clean, unified feed. Let me know what you think! uncited.org
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Mitch Guttman (@mitchguttman) profile picture
Mitch Guttman@mitchguttman15 Nov 2024
A report made counterintuitive claims that PRC2 binds → more RNA than PTBP1 & hnRNPU → RNAs that do not exist in the cell We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions. biorxiv.org/content/10.1101/…
Failing to account for RNA quantity inflates background and leads to the misleading appearance that...

Failing to account for RNA quantity inflates background and leads to the misleading appearance that...

We recently published biochemical and quantitative evidence that challenges the widespread claims that PRC2 binds directly to many RNAs in vivo . A recent preprint performs a re-analysis of some of...

biorxiv.org
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Sophie Polo Lab (@PoloSophie) profile picture
Sophie Polo Lab@PoloSophie6 Nov 2024
We are recruiting a Post doc to work on Epigenetics and Cancer!
Image from Sophie Polo Lab (@PoloSophie)
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Emmanuel Cazottes retweeted
Alex de Mendoza (@deMendoza_Alex) profile picture
Alex de Mendoza@deMendoza_Alex28 Oct 2024
Does 6mA exist in eukaryotic DNA? This is our take on this dispute: yes it does, and can be very abundant, but mostly correlates with presence of the MT-A70 writer AMT1. Then, 6mA is associated with transcriptionally-permissive chromatin (H3K4me3) 1/6: biorxiv.org/content/10.1101/…
Adenine DNA methylation associated to transcription is widespread across eukaryotes

Adenine DNA methylation associated to transcription is widespread across eukaryotes

DNA methylation in the form of 5-methylcytosine (5mC) is widespread in eukaryotes, while the presence of N6-methyladenine (6mA) has sparked considerable debate. Methodological disparities in quanti...

biorxiv.org
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Emmanuel Cazottes retweeted
Geoff Fudenberg (@gfudenberg) profile picture
Geoff Fudenberg@gfudenberg15 Oct 2024
Great opportunity for new PhD students to join us @qcb_usc!
Mark Chaisson (@mjpchaisson) profile pictureMark Chaisson@mjpchaisson14 Oct 2024
The USC/QBIO department is now accepting applications for the CBB PhD program. Please share with any interested undergraduate and Master's students. qcb-dornsife.usc.edu/applica… We will have zoom information sessions Nov 1 and 15, please contact me directly for a registration link.
Image from Mark Chaisson (@mjpchaisson)
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.1101/… (1)
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...

biorxiv.org
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Emmanuel Cazottes retweeted
Active Motif (@activemotif) profile picture
Active Motif@activemotif26 Jul 2024
[NEW Podcast] We talked with Dr. Claire Rougeulle from @ParisEpigenetix about her work on gene expression control, the intricacies of X-chromosome inactivation & the potential of non-coding RNAs in this process Tune in! bit.ly/3LFSkAh #podcast #epigenetics #Paris2024
Image from Active Motif (@activemotif)
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Claire Rougeulle (@CRougeulle) profile picture
Claire Rougeulle@CRougeulle5 Jun 2024
Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development pubmed.ncbi.nlm.nih.gov/3883… Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix
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Emmanuel Cazottes retweeted
Aurélie Richard (@aurelieRCHRD) profile picture
Aurélie Richard@aurelieRCHRD17 May 2024
🎉 Excited to announce our latest team paper on the role of ESCRT-III protein methylation in abscission regulation! Huge thanks to the team at @WeitzmanlabP and our amazing collaborators! 🔗 Link below 👇🏻 doi.org/10.1038/s41467-024-4…
Methylation of ESCRT-III components regulates the timing of cytokinetic abscission

Methylation of ESCRT-III components regulates the timing of cytokinetic abscission

Nature Communications - Methylation of CHMP2B regulates abscission timing by modulating ESCRT-III dynamics during cytokinesis. This methylation also plays a role in HIV-1 budding, highlighting the...

nature.com
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Emmanuel Cazottes retweeted
Huret Christophe (@Huret_C) profile picture
Huret Christophe@Huret_C4 May 2024
Hapoy to share our latest paper after a long but amazing project. Thanks @celinemorey, @CRougeulle and all collaborators. Altered X-chromosome inactivation predisposes to autoimmunity | Science Advances science.org/doi/full/10.1126… @univ_paris_cite @CNRS @Inserm @ParisEpigenetix
Altered X-chromosome inactivation predisposes to autoimmunity

Altered X-chromosome inactivation predisposes to autoimmunity

Perturbation of X-chromosome inactivation, a female-specific process, induces signs of lupus, a disease that mostly affects women.

science.org
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Emmanuel Cazottes retweeted
Labex Who Am I? (@labexWhoamI) profile picture
Labex Who Am I?@labexWhoamI23 Apr 2024
Tonight, we prepare our speakers and event managers for #pint24 💪🏻 @EloScicomm is sharing all the tips for great nights of science discoveries 🤩🧫🔬🦠 pintofscience.fr/events/pari… – at Paris, France
Image from Labex Who Am I? (@labexWhoamI)
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Emmanuel Cazottes retweeted
Michael Fischbach (@mfgrp) profile picture
Michael Fischbach
@mfgrp11 Apr 2024
How to pick a problem. Today in @CellCellPress. 1/53 cell.com/cell/fulltext/S0092…
Problem choice and decision trees in science and engineering

Problem choice and decision trees in science and engineering

Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for...

cell.com
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Emmanuel Cazottes retweeted
Julia Bauman (@JuliaBauman2) profile picture
Julia Bauman
@JuliaBauman221 Jun 2023
Can scientists be taught how to choose good projects? I took a fantastic class taught by @mfgrp last quarter where the foundational hypothesis is: Yes, they can! And I continually come back to these core insights as I think about project choice and direction in my 2nd year of PhD:
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Huret Christophe (@Huret_C) profile picture
Huret Christophe@Huret_C3 Apr 2024
I'm very happy to see that our work on XCI and autoimmunity inspired some discussion. @ParisEpigenetix #rougeullelab
Preprint Club - Immunology (@preprintclub) profile picturePreprint Club - Immunology@preprintclub2 Apr 2024
Today #PreprintHub2 with Laura Gebetsberger @MedUni_Wien had a nice #preprint discussion on how altered #X-chromosome inactivation predisposes to #autoimmunity from @Huret_C & Céline Morey @CRougeulle 🐭👩👇 biorxiv.org/content/10.1101/…
Altered X-chromosome inactivation predisposes to autoimmunity

Altered X-chromosome inactivation predisposes to autoimmunity

In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases while females are more susceptible to systemic autoimmunity....

biorxiv.org
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✨Retrouvez @manucazottes, de l'équipe @CRougeulle, dans une soirée #pint24 dédiée à l'adaptation ! 👉pintofscience.fr/event/face-… ❗️La billetterie ouvre lundi 8 avril !

Face aux changements environnementaux, s'adapter

Comment évoluerons les espèces que nous connaissons face aux changements rapides de notre environnement ? L'évolution du génome, qui a permis à toutes les …

pintofscience.fr
Pint of Science FR (@pintofscienceFR) profile picturePint of Science FR@pintofscienceFR25 Mar 2024
🎉ÇA Y EST !! Le programme #pint24 de presque toutes les villes est en ligne !! À consulter ici 👉pintofscience.fr 👈 🎫Vous avez deux semaines pour le découvrir tranquillement, les tickets seront en ligne lundi 8 avril ! 👓🧠❤️‍🔥Alors, quelle est votre soirée préférée ?
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Rafael Galupa (@rafaelgalupa) profile picture
Rafael Galupa@rafaelgalupa8 Mar 2024
Beautiful story from the amazing @TimPollex!! Congrats to all other authors too!
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell7 Mar 2024
Chromatin gene-gene loops support the cross-regulation of genes with related function dlvr.it/T3mTjg
Image from Molecular Cell (@MolecularCell)
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Emmanuel Cazottes retweeted
Connor Horton (@connorh_sci) profile picture
Connor Horton@connorh_sci20 Feb 2024
Today starts a new era of genome engineering! We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! @CollinsRNPLab @berkeleyMCB A thread 🧵: nature.com/articles/s41587-0…
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Sophie Polo Lab (@PoloSophie) profile picture
Sophie Polo Lab@PoloSophie17 Jan 2024
Check out our last paper focusing on altered DNA repair in H3.3 mutant pediatric high-grade glioma! We identified a specific molecular vulnerability with potential for therapeutic targeting. Thank you to our collaborators. pubmed.ncbi.nlm.nih.gov/3821…
Image from Sophie Polo Lab (@PoloSophie)
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🚨New paper out! Congratulations @PoloSophie group and collaborators 👏👏👏 👉epigenetics.u-paris.fr/new-r…
Sophie Polo Lab (@PoloSophie) profile pictureSophie Polo Lab@PoloSophie17 Jan 2024
Check out our last paper focusing on altered DNA repair in H3.3 mutant pediatric high-grade glioma! We identified a specific molecular vulnerability with potential for therapeutic targeting. Thank you to our collaborators. pubmed.ncbi.nlm.nih.gov/3821…
Image from Sophie Polo Lab (@PoloSophie)
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Claire Rougeulle (@CRougeulle) profile picture
Claire Rougeulle@CRougeulle5 Dec 2023
We are excited to share with you the work of @manucazottes, nicely posted the day before his thesis defense! With @CharbelFeghaly @agnese_loda @heard_lab @PSavatier and many othersExtensive remodelling of XIST regulatory networks during primate evolution biorxiv.org/content/10.1101/…
Extensive remodelling of XIST regulatory networks during primate evolution

Extensive remodelling of XIST regulatory networks during primate evolution

Unravelling how gene regulatory networks are remodelled during evolution is crucial to understand how species adapt to environmental changes. We addressed this question for X-chromosome inactivation,...

biorxiv.org
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