Gribnau lab (@GribnauLab) profile picture

Twitter account of the lab of Joost Gribnau at the department op developmental biology at Erasmus MC, Rotterdam. Run by PhD students

Erasmus MC, Rotterdam
Joined December 2021
Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)Photo by Gribnau lab (@GribnauLab)
Gribnau lab retweeted
📢 WE ARE HIRING! We offer a position as Research Technician in Stem Cell Biology to work in sex differences in neurodevelopmental disorders and human X chromosome inactivation. More info: werkenbijerasmusmc.nl/en/vac…
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Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development pubmed.ncbi.nlm.nih.gov/3883… Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix
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Interested in understanding the variances in embryonic development and stem cells between mice and humans, and how these differences impact the formation of integrated stem cell-based embryo models? Delve into our lab's Catherine Dupont latest review! frontiersin.org/articles/10.…
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Gribnau lab retweeted
An amazing Troppo Breve meeting just finished with all NOCI members in Lochem. 4 amazing days full of discussions for directions and collaborations. Special thanks to the organizers @F_deVrij, @GribnauLab and Ellen Thomassen. #NOCI #OoC #organonachip #research #troppobreve
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Gribnau lab retweeted
📢 Register for the 5th 🧬 X-inactivation meeting before April 1! 📔 25 talks selected from abstracts! 📅 19.-22.6.2023 in #Berlin ℹ️ x-inactivation-meeting.org 🧑‍💻👩‍💻co-organizers: @rafaelgalupa @lab_turner @GribnauLab @CRougeulle #EMBOxChromosome23 @EMBOevents @dfg_public
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Retrospective analysis of enhancer activity and transcriptome history go.nature.com/3lZYa66
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After many years of hard work, our DCM time machine paper is finally published in @NatureBiotech! Ruben Boers, Joachim Boers, @Beatrice__Tan, @Mariekevleeuw, @gribnau_joost and others developed a novel technology for whole-genome cell state tracing rdcu.be/c6fsf
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DCM-Polr2b also labels active enhancers, which show a coordinated timing with nearby gene activity. We used the gene and enhancer maps to predict transcription factor activity and study the changes in chromatin landscape and lineage decision-making during intestinal homeostasis.
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We believe DCM-TM is a powerful technology for tracing genome-wide gene transcription and enhancer activity back in time without relying on predictions or the requirement to isolate stem cells. Read our paper to learn more on our findings! 🤩
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❔ Interested in #embryoids? This @ScienceAdvances article details an optimized method for generation of ETX embryoids that developed into late #gastrulation in static culture conditions. @GribnauLab @Beatrice__Tan Check it out: bit.ly/3HjqYxk 🔬 #MicroscopyMonday
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We are extremely excited to present the amazing EXT embryoid work Catherine Dupont, @Beatrice__Tan, Olivier Schäffers and others published this week in @ScienceAdvances. We managed to optimize protocols to create the post efficient protocol yet! science.org/doi/10.1126/scia…
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The EXT embryoids could be grown to spatially and morphologically resemble up to E7.5 embryos. Day-7 ETX embryoids can display a headfold and formation of the heartgut region, even in non organogenesis directed culture conditions.
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We believe this research can greatly contribute to the research into developmental events! Thank you everybody that contributed to this study! @ErasmusMC @AnZwijsen Enjoy reading!
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New dropbox has been set up at Erasmus University Medical Center @erasmusuni in Rotterdam, NL! Pickups are Mondays at 3pm, located in the coldroom in the Ee tower (Ee 964). Thanks to Esmee Brevé for hosting this new box! 👩‍🔬👨‍🔬🧑‍🔬
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