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EARLY conclusions Autonomous surgical robots exist and they are better at the mechanics than our bench rig tbh. But in every one of them, a human decided what operation to perform, and the robot executed it. Nobody told this agent what to give or where to put it. It got a phenotype and a shelf of candidates and had to work out the therapy and the coordinates itself. I am not aware of an agent previously choosing a treatment and a brain target and then delivering it into a living mammal. This is what we mean by in vivo lab in the loop. FULLY connecting agents to our experimental capabilities. More on this soon. P.S.: Mouse recovered well! Full write-up soon on substack

Last night an AI agent performed brain surgery on a mouse. We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures. It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding. A licensed vet gated every irreversible step and held a physical kill switch to stop the AI agent. Thread on what it decided, what it saw, and the moment it refused to let me override it. [Writing this on the spot out of excitement, but I've been 18hrs in front of my laptop coding and coordinating this, so keeping it brief and descriptive, more cohesive thoughts on this soon...]