I am interested in web development, AI, technology, and the sciences of fitness, well-being, and brain health.
Joined August 2009
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Dan Patrick retweeted
Look, if it weren’t for competition they could literally sell Opus 5.5 tokens forever and companies would pay for it until the end of time
The AI bubble bursting is going to be one of the biggest reality checks in tech history. These companies have spent years convincing us that AI is the future while burning billions, destroying jobs, draining natural resources and forcing products nobody asked for into our daily lives. Eventually, the hype has to meet reality.
Dan Patrick retweeted
3 eggs/day is the prescription to keep the brain from fading away
Higher choline intake thru diet = 33% lower odds of cognitive decline
Dan Patrick retweeted
The Dietary Polyphenol Epigallocatechin Gallate Delays Biological Aging by Activating Peroxisome Biogenesis and Peroxisomal Fatty Acid β‐Oxidation
Tea, both black and green, is the major source of EGCG
onlinelibrary.wiley.com/doi/…
Dan Patrick retweeted
Pro tip: just send the link to this article directly to your dot and it'll create a responsibilities page for you
Then go into that Page and delete the ones you don't want, and ask dot to add the ones you do want
Dan Patrick retweeted
We are part of something so awe inspiring.
We were taught that Earth orbits the Sun in a closed circle. In reality, Earth has never returned to the same point in space once in 4.5 billion years.
Right now, the Sun is carrying Earth and every planet around the center of the Milky Way at 230 km/s (828,000 km/h), more than 18,000 kilometers every 80 seconds.
Because the Solar System is tilted 60.2° to the galactic plane and bobs up and down through the galactic disc roughly every 30 million years, the planets trace open 3D corkscrew helices across deep space rather than flat loops.
The last time the Sun stood where it stands today, one Galactic Year (230 million years) ago, the very first dinosaurs were only beginning to appear on Earth. Since forming 4.6 billion years ago, our Sun has completed only 20 laps.
Dan Patrick retweeted
Absolutely incredible: MIT researchers say GPT-6 Astra improved a small Qwen model’s math score from 7.9% to 48.1% by directly editing just 0.016% of its weights, without gradient-based training.
The result points toward AI systems that can diagnose and improve other models directly, a potential step toward self-improving AI.
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.
We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weigh…
If you’re using GPT Pro it performs better with a.) memory turned off b.) 160,000 tokens of surgically curated context via @RepoPrompt
Dan Patrick retweeted
Running had similar effects to antidepressants for mental health, but significantly outperformed on physical health metrics.
Dan Patrick retweeted
Listen, I can get behind some high-quality content even if it’s AI-generated.
But the clearly AI formulated replies to posts are cringe. Like, you can’t put any constructive thought into a response?
What’s to be gained from this strategy anyway?
Dan Patrick retweeted
‘People don’t expect me to have a Yorkshire accent.’
Sir Patrick Stewart @sirpatstew has been embracing his Yorkshire roots with @SamiraAhmedUK on @bbcRadio4 this week.
Catch up with the full interview on @bbcsounds now. ⬇️
Dan Patrick retweeted
Very cool! Babies’ internal clocks may even start developing before birth.
Expecting mothers with more regular sleep schedules also tended to have babies who slept more at night.
Your sleep schedule during pregnancy may help shape your baby’s body clock.
Dan Patrick retweeted
Guys, I beg you to start being the person you wish to be. This study found that just 5 minutes a day of imagining your best possible self, for two weeks, made people noticeably more optimistic about their future. Picture who you want to be, then go act like them today.
Dan Patrick retweeted
Does HIIT and other cardio limit strength increases from resistance training? This brief @Brady_H post summarizes the recent data well. In the meantime, I’m going to continue to do both.
A while back, @hubermanlab tagged me in a post asking “can you get strong and fast at the same time?”
Tl;dr: Probably, though not always. But it's not because cardio "kills gains."
The best example of this comes from a 2026 study.
Two groups did the exact same lifting program for 16 weeks. One also did 4 long-interval HIIT sessions a week.
Muscle fibers grew the same (~19% vs. ~18%), protein synthesis rose the same, but leg press strength gains were blunted by about 40% in the group that added intervals! That was in the context of an 11% bump in peak aerobic capacity.
So cardio didn't stop muscle growth, but it did cost max strength.
I think it makes sense that the “tradeoff” would manifest at the level of functional performance, for those concerned. If endurance work is borrowing energy from quality strength work, you won’t optimize the latter (and vice-versa).
Dan Patrick retweeted
Interesting: U.S. coastal counties with higher levels of microplastic pollution in nearby waters also tend to have higher rates of cancer.
Dan Patrick retweeted
ADHD is a superpower.
"The problem isn't that I can't focus; it's that I can't focus on stuff I don't care about."
"On stuff I care about, I can lock in and you’re not going to find me for months."
So if you have ADHD ...
"The first thing you have to do is reframe the task to find the autonomy."
My conversation with @steven_kotler on flow, cognitive performance, and doing your best work.
Kotler is the executive director of the Flow Research Collective, where he studies flow and the science of peak performance.
In this episode, you’ll learn:
• How to get so absorbed in what you’re doing that distractions fade.
• How to find a challenge that holds your attention without overwhelming you.
• Why a hobby you gave up might be worth picking up again.
• What frustration tells you when you’re learning and how to respond.
• How to focus on work you don’t feel like doing.
• How to think clearly when there’s too much information, and you’re unsure what to trust.
Listen and Learn
(Includes paid partnerships.)
Dan Patrick retweeted
New: Adiposity, not chronological aging, is the dominant determinant of circulating testosterone in US adult men
As with many other markers associated with aging (e.g. insulin resistance), the real culprit is excess body fat.
h/t @RicardoMTorr
pmc.ncbi.nlm.nih.gov/article…
Dan Patrick retweeted
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
openai.com/index/scaling-ai-…
