MRC Career Development Fellow - group leader @UniofOxford. Medical Research Fellow @CorpusOxford. Also on https://nitter.cf/t.co/voX9Vygwwz opinions my own
England, United Kingdom
Joined October 2014
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Really pleased to see this Opinion Review out.
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology
cell.com/trends/immunology/f…
Malcolm Sim retweeted
In lieu of flowers, memorial contributions may be made to:
Johns Hopkins Alzheimer’s Disease Research Center Fund
alzresearch.org/giving/
Alzheimer’s Foundation of America Caregiver Resources
alzfdn.org/donate/
Photo Credit: Tommy Garcia
Malcolm Sim retweeted
🚨New collaborative paper with @KathyHsuLab. We show that NKG2C+CD8+ TKLR cells can be TCR/CAR-engineered to deliver potent antitumor activity with ⬆️persistence, ⬇️ exhaustion, and ⬇️CRS potential. @MSKCancerCenter @MSK_DeptOfMed @parkerici @JCI_org jci.org/articles/view/193053
Malcolm Sim retweeted
An all male panel at an international conference for breast surgeons has sparked outrage among senior doctors.
The 14 member panel at the London Breast Meeting, staged last month, was described as “shameful” by commentators
bmj.com/content/395/bmj-2026…
Malcolm Sim retweeted
Antigen discovery and TB vax friends 🧵
We set out to find more Mtb peptides presented on MHC-I. We had a strong biological prior, a high-throughput binding screen, and a very sensitive targeted MS assay.
Of 286 candidates, we detected 2.
biorxiv.org/content/10.64898…
Malcolm Sim retweeted
@biorxivpreprint @ragoninstitute Self-reactive human CD8+ T cells restricted by HLA-E mediate immunoregulatory and antiviral functions
biorxiv.org/content/10.64898… @brucedwalkermd
Malcolm Sim retweeted
Bottlenecks in the study of TCR-antigen specificity:
nature.com/articles/s41592-0…
Malcolm Sim retweeted
Multidimensional view of immunotherapy @ImmunityCP
cell.com/immunity/fulltext/S…
Malcolm Sim retweeted
Specificity defines adaptive immunity. Yet we've never comprehensively tested how differences in the epitopes human T cells recognize correlate with disease risk. I explore why in this review & argue we now have the tools to change it 🧵1/12 onlinelibrary.wiley.com/doi/…
Malcolm Sim retweeted
We've become very good at dividing T cells into ever finer subsets: exhausted, progenitor exhausted, resident, stem-like...every day, a new subset.
But amid all this subsetting, a critical question often goes unanswered:
What do these cells actually recognize? (2/12)
Malcolm Sim retweeted
Online Now: Chemotherapy enhances cancer vaccine efficacy and expands stem-like TCF1+CD8+ T cells dlvr.it/TVlbXr
Malcolm Sim retweeted
Hi, we would like to introduce PAIR-Scan, an HLA-agnostic library-on-library screening technology that can identify reactive TCR–antigen pairs with optimal killing activity among up to ~100,000 possible candidate pairs in a single-step.
🧵(1/7)
biorxiv.org/content/10.64898…
Malcolm Sim retweeted
Now online: Peripheral Blood as the Sole Source for Cancer Neoantigen and Reactive T-Cell Discovery doi.org/10.1158/2159-8290.CD…
Malcolm Sim retweeted
@biorxivpreprint A temporal threshold in TGF-β signaling separates reversible tissue adaptation from persistent NK cell effector dysfunction
biorxiv.org/content/10.64898…
Malcolm Sim retweeted
Excited to share our new preprint!
We use somatic mutations to show how a central principle of adaptive immunity - clonal selection - shapes innate immune memory to viral infection.
A huge thanks to all co-authors and collaborators!
biorxiv.org/content/10.64898…
Malcolm Sim retweeted
Millions of PBMCs have been analyzed by scRNA-seq. Have we seen it all ?
We profiled thousands of single PBMCs — proteomes and transcriptomes side by side — and uncovered functional coordination undetectable in the deepest scRNA-seq we could perform.
biorxiv.org/content/10.64898…
1/
Malcolm Sim retweeted
We've been quiet, but we've been busy! Delighted to share that in recent weeks we have received 3 NIH R01s to continue our studies of adaptive immunity in the gut! As such, we are recruiting post-docs with strong interests and expertise in mucosal immunology and (1/3)
Malcolm Sim retweeted
Final version of @NeehaZaidi paper on Mutant KRAS Vaccine for #PancreaticCancer interception in high risk cohorts out in @CD_AACR.
aacrjournals.org/cancerdisco…
Notable data is detection of KRAS antigen targeted T cells 1 year post vaccine - annual boosters as a prevention strategy?
New single cell buzzword alert 🚨 ‘immune panorama’ 🚨
Double points for also using atlas in the title and landscape in the graphical abstract.
A single-cell transcriptomic atlas reveals the immune panorama of neonatal sepsis @CellReports
cell.com/cell-reports/fullte…
