Xiaolin Nan (@nanxiaolin) header
Xiaolin Nan (@nanxiaolin) profile picture

Xiaolin Nan

@nanxiaolin

Nanobiology Lab @ Oregon Health & Science University

 Portland, OR
Joined January 2010
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  • Following413
  • Followers262
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Photo by Xiaolin Nan (@nanxiaolin)Photo by Xiaolin Nan (@nanxiaolin)
30-COLOR DNA-PAINT at sub-15 nm RESOLUTION. I am overly excited to tell you about "Spatial proteomics in neurons at single-protein resolution" our latest work led and developed by my brilliant and amazing colleague Eduard Unterauer. 1/8 biorxiv.org/content/10.1101/…
Spatial proteomics in neurons at single-protein resolution

Spatial proteomics in neurons at single-protein resolution

To fully understand biological processes and functions, it is necessary to reveal the molecular heterogeneity of cells and even subcellular assemblies by gaining access to the location and interact...

biorxiv.org
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In this article, @nanxiaolin @Scientistic212 et al (@OHSUKnight) provide a detailed guide for fast and multiplexed superresolution imaging on cells using DNA-PAINT-ERS, with many useful tips for great results. currentprotocols.onlinelibra…
Fast and Multiplexed Super Resolution Imaging of Fixed and Immunostained Cells with DNA‐PAINT‐ERS

Fast and Multiplexed Super Resolution Imaging of Fixed and Immunostained Cells with DNA‐PAINT‐ERS

Recent advances in super resolution microscopy have enabled imaging at the 10-20 nm scale on a light microscope, providing unprecedented details of native biological structures and processes in...

currentprotocols.onlinelibrary.wiley.com
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#STED at Å precision! See nature.com/articles/s41587-0… New article by Weber, von der Emde et al. Fantastic applications ahead; stay tuned! #Nanoscopy #Superresolution #Microscopy @mpi_nat
Image from Stefan W. Hell (@Stefan_W_Hell)
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Research Highlight by @rita_strack: Researchers use electric fields to transfer RNA from a tissue onto a surface for subsequent FISH-based spatial transcriptome analysis. Paper: nature.com/articles/s41587-0… Highlight: nature.com/articles/s41592-0…
Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

Nature Biotechnology - EEL FISH profiles spatial transcriptomes in single cells in large, complex tissue samples.

nature.com
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Xiaolin Nan retweeted
Rita Strack (@rita_strack) profile picture
Rita Strack@rita_strack1 Nov 2022
The tools for getting the most information out of highly multiplexed tissue imaging data are just getting better and better. From a methods perspective, it's so fun to see a big wave of new acquisition methods followed by a second, huger wave of analysis tools. Check out UTAG!!
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SOOO EXCITED to finally, officially introduce CODA, a method for 3D reconstruction by myself,PeiHsun Wu @deniswirtz, and @lauradelongwood
Nature Methods (@naturemethods) profile pictureNature Methods@naturemethods24 Oct 2022
CODA is a method for 3D reconstruction of large tissues at subcellular resolution from serially sectioned H&E images, from Pei-Hsun Wu, @deniswirtz and colleagues. @johnshopkins @ashleykiemen nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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Reto Fiolka (@RetoPaul) profile picture
Reto Fiolka@RetoPaul24 Oct 2022
We present doubled resolution in light-sheet microscopy via multi-directional structured illumination. This enables SIM imaging at 1Hz volume rate of subcellular dynamics. nature.com/articles/s41592-0…
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Very proud of our work published today on noncoding genes that are essential for chromosome stability. More to come soon. nature.com/articles/s41467-0…
Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability

Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability

Nature Communications - Heskett et al. describe several members of a class of long non-coding RNAs, known as ASARs, which show distinct epigenetic regulation between subclonal lineages and are...

nature.com
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🚨Hot off the press in @NatureMedicine👉After KRAS G12C going after the next undruggable-KRAS G12D👉Anti-tumor efficacy of a potent & selective non-covalent KRAS G12D inhibitor 🎯🧬Huge implications in #precisionmedicine if translated to clinic @oncoalert go.nature.com/3ExqaoJ
Image from Vivek Subbiah, MD (@VivekSubbiah)
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High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging go.nature.com/3CN3vnj
Image from Nature Biotechnology (@NatureBiotech)
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Jie Xiao (@JieXiao_Lab) profile picture
Jie Xiao@JieXiao_Lab29 Sep 2022
Physics is stochastic but biology is deterministic? Or, biology is stochastic but physics is deterministic? If you are puzzled by the questions, look no further but at the 2023 GRC Stochastic Physics in Biology grc.org/stochastic-physics-i…. Join us!
Image from Jie Xiao (@JieXiao_Lab)
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Nanoscopic Spatial Association between Ras and Phosphatidylserine on the Cell Membrane Studied with Multicolor Super Resolution Microscopy mdpi.com/1745068 #mdpibiomolecules via @Biomol_MDPI
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🚨🔬😍 Our review on mapping molecular complexes through #SuperResolution #Microscopy is out!! Highlighting many recent exciting studies. A brainchild of @afonsomendes92 and @Hannah_SuperRes in collaboration with @simaopc and @christlet. Check it out at doi.org/10.1098/rsob.220079
Image from Ricardo Henriques (@HenriquesLab)
Image from Ricardo Henriques (@HenriquesLab)
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Multipair Förster Resonance Energy Transfer via Spectrally Resolved Single-Molecule Detection pubs.acs.org/doi/10.1021/acs…
Multipair Förster Resonance Energy Transfer via Spectrally Resolved Single-Molecule Detection

Multipair Förster Resonance Energy Transfer via Spectrally Resolved Single-Molecule Detection

Abstract. Förster resonance energy transfer (FRET) is a powerful tool for studying molecular interactions. Its use for studying interactions involving mor

pubs.acs.org
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Xiaolin Nan retweeted
Taekjip Ha (@taekjip) profile picture
Taekjip Ha@taekjip1 Jun 2022
Achieving single nucleotide sensitivity in direct hybridization genome imaging biorxiv.org/content/10.1101/…
Achieving single nucleotide sensitivity in direct hybridization genome imaging

Achieving single nucleotide sensitivity in direct hybridization genome imaging

Direct visualization of point mutations in situ can be informative for studying genetic diseases and nuclear biology. We describe a direct hybridization genome imaging method with single-nucleotide...

biorxiv.org
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Xiaolin Nan retweeted
Rita Strack (@rita_strack) profile picture
Rita Strack@rita_strack1 Jun 2022
A very nice Review on multiplexed imaging in oncology out in NBME from Ralph Weissleider and colleagues. I spend so much time thinking about basic science, I love seeing how all this work impacts medicine. nature.com/articles/s41551-0…
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Actin cytoskeleton branching complex: PDB 7TPT #blender #Blender3d #b3d
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That @BMESociety abstract deadline is coming up quick, so here’s your annual reminder…
Image from Michael King (@profmikeking)
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Gear up for our next MGO PI webinar, featuring Prof. @taekjip Ha and Prof. Aleksei Aksimentiev: Wednesday, May 25th, 11 am ET. Register for zoom link here: latech.zoom.us/meeting/regis…
Image from Multiscale Genome Organisation (@MGO_BPS)
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Out today from @wmarkbates and @Stefan_W_Hell @StefanHellLabs: A dynamic model of the 4Pi PSF enables localization microscopy with exceptional three-dimensional resolution and a simpler optical design.
Image from Nature Methods (@naturemethods)
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