CryoEM Scientist @HHMIJanelia | Former @UVA postdoc | Nintendo Enthusiast | 2X Middle School badminton champ
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Joined June 2012
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Nick Spellmon retweeted
If you grew up in the 90s’ or early 00s’ and were in middle school during that time, alongside the likes of Harry Potter, Animorphs, and Eragon, there is a good chance you were also reading Brian Jacques’ Redwall series.
Here's how to read all the Redwall books in order: bit.ly/47Tj0Zr
Wow! Honored to see our study on the front cover of Science Magazine!
Shout out to our cryo-EM team and the AI designers. This is an exciting milestone in RNA biology and artificial intelligence ❄️🔬🧬
On the citizen science platform Eterna, #AI methods matched expert human players at inventing sequences that fold into an RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule.
This opens a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch.
Learn more this week in Science: scim.ag/4wPnPwM
ALT Each diagram is a designed RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule. On the citizen science platform Eterna, artificial intelligence methods matched expert human players at inventing sequences that fold into these shapes, opening a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch. Image: J. Townley et al., Science 393 , 931 (2026); Adapted by N. Jessup/Science
Nick Spellmon retweeted
On the citizen science platform Eterna, #AI methods matched expert human players at inventing sequences that fold into an RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule.
This opens a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch.
Learn more this week in Science: scim.ag/4wPnPwM
ALT Each diagram is a designed RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule. On the citizen science platform Eterna, artificial intelligence methods matched expert human players at inventing sequences that fold into these shapes, opening a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch. Image: J. Townley et al., Science 393 , 931 (2026); Adapted by N. Jessup/Science
Another cool #RNA structure from our team! #cryoEM provides structural insights into the in vitro selected RNA polymerase ribozyme, tC19z @HHMIJanelia
Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at LMB MRC 15 y ago! biorxiv.org/content/10.64898… @Szokoli_Deni Jason Hingey, Dan Haack, Vivian Wu @nickspellmon @navtejtoor @HHMIJanelia
Nick Spellmon retweeted
Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at LMB MRC 15 y ago! biorxiv.org/content/10.64898… @Szokoli_Deni Jason Hingey, Dan Haack, Vivian Wu @nickspellmon @navtejtoor @HHMIJanelia
Nick Spellmon retweeted
First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv doi.org/10.64898/2026.05.21.…
We resolved the molecular structure of several AI-generated RNA molecules with a novel RNA fold, including the first atomically-ordered RNA designed by AI at 2.9Å! 🧬🔬❄️
Congratulations to all contributors and @HHMIJanelia. It was a wonderful surprise to process this beautiful high resolution cryo-EM map and find non-canonical base pair interactions within the RNA structure.
PDBs 10ZT, 10ZU, 11AG, and 11EH release next week!
First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv doi.org/10.64898/2026.05.21.…
Code red for Nintendo 🚨
U.S. video game hardware sales in November were the lowest by units since November 1995 at 1.6 million per @WeAreCircana
Top selling hardware:
1. PlayStation 5
2. Nintendo Switch 2
3. Nex Playground
4. Xbox Series X/S
Interesting trend. Could be due to social media influence and wearable biosensor use. Great to see.
Take a minute to admire the graphics on this burger. Good Wowza #DonkeyKongBananza
A good “deer” friend of ours visited us on the roof this morning @HHMIJanelia
Wonderful tribute to Iwata and Nintendo's partnership with @nvidia
In this special edition of #CreatorsVoice, NVIDIA CEO Jensen Huang shares some insights into the creation of #NintendoSwitch2’s custom processor.
Watch more Creator’s Voice videos here: ninten.do/6014SlL7o
Nick Spellmon retweeted
Today is the memorial of Saint Joseph, the patron of workers and an exemplar for us. By persevering in work as St. Joseph did, we may learn more about ourselves and God, but this requires a death to ourselves. Yet if we do die to ourselves, in admitting our weaknesses, then we are able to see the love of God, present and supporting us. The one who works for God comes to love him ever more.
—Br. Michael Prize, O.P.
