Norwegian PURE-3®

The relationship of #Omega3 fatty acids with #Dementia and cognitive decline: (@ADNI3study + prospective cohorts): "Our findings support the hypothesis that the efficacy of omega-3 fatty acid supplementation is dose-dependent. We found that omega-3 fatty acid supplementation was significantly associated with a decreased risk of #Alzheimers, particularly among long-term users. The risk of cognitive decline decreased when the intake of omega-3 fatty acids exceeded 1.0 g/d. For this reason, we propose that 1.0 g/d may be the threshold dosage of omega-3 fatty acids for the prevention of cognitive decline." sciencedirect.com/science/ar…

#Atherosclerosis is a systemic pro-inflammatory/pro-oxidative disease, accounting for a third of deaths globally. New systematic review suggests increasing #Omega3/upper limits of daily intake to improve clinical outcomes/reduce risk of cardiac mortality. academic.oup.com/nutritionre…

New major study of aging human brains shows progression to #Alzheimers disease trajectory starts with lipid/inflammation-related pathways. And @foundmyfitness & @AxL_Montagne have an excellent talk about #Omega3/dementia prevention. biorxiv.org/content/10.1101/… youtube.com/watch?v=of6OWL9V…

And @UriAlonWeizmann/@IdoAmitLab shows #Rejuvenation strategies converge on reduced inflammation & restored fatty acid metabolism. "Argues in favor of directly targeting inflammation & fatty acid metabolism pathways to mitigate age-related health decline." biorxiv.org/content/10.1101/…

@CNSerhanLab: #ResolutionMedicine: are we on track to address the next Pandemic (& #Aging)? link.springer.com/article/10… A new high-sensivity method for measuring #Oxylipins/#SPMs: jlr.org/article/S0022-2275(2… And #Maresin2 (DHA) is another pro-repair molecule: pnas.org/doi/10.1073/pnas.22…

A new large Atlas of 249 plasma biomarkers for health & disease in 118,461 individuals from the @uk_biobank confirms #Omega3 levels are at top for #AntiAging/disease. The findings were replicated in 5 cohorts in Finland with over 30 000 individuals. nature.com/articles/s41467-0…

We now have reasons to suspect that rTG-form #Omega3 may be substantially more potent for Anti-inflammatory effects than other Omega-3 forms. May be especially important regarding #DHA and all-important #NFkB targets for #AntiAging. More to come, also see: lipidworld.biomedcentral.com…

Happy 2023, new #Omega3 & #Cognition review shows the complexity of Omega-3 studies. Most used low doses & many studies using low potency/quality products but ~70% of RCTs with MCI patients reported improved cognitive scores compared to placebo. #AntiAging sciencedirect.com/science/ar…

Merry Xmas to everyone🎄and an excellent recent review on #Omega3's as #Antiaging #NRF2 inducers. "N-3 PUFA & their metabolites may be recognized as potential agents to restore cellular redox state, slow down aging & prevent age-related pathologies."🧬 sciencedirect.com/science/ar…

#Omega3 - The multipoint anti-inflammatory strategy. Enormous anti-inflammatory signal convergence important for #Antiaging: GPR120/PPARγ activation → Blocks multilevel #NFkB activity + #NLRP3 blockade, Macrophage regulation, SPMs & more. tandfonline.com/doi/10.1080/…

We have the same experience (many individuals). #ChronicInflammation must seemingly be counteracted/resolved continuously & the enhanced tissue regeneration we've observed is also likely mediated 24/7 with chronic SPM elevation etc. ncbi.nlm.nih.gov/pmc/article… nitter.cf/npure3/status/13393145…

Reawakening #GDNF's Regenerative past in humans? "Activating GDNF-GFRα1 signaling may be a method of promoting complete limb & skin regeneration in less regenerative animals like humans." EPA/DHA #Omega3 are potent GDNF activators🧬 sciencedirect.com/science/ar… nature.com/articles/s41380-0…

Effect of #Omega3 Fatty Acids on Telomeres—Are They the Elixir of Youth? mdpi.com/2072-6643/14/18/372… Recent reviews also connects Telomere dysfunction & aging/chronic inflammation, chronic stress, DNA damage & mitochondrial dysfunction. nature.com/articles/s41556-0… sciencedirect.com/science/ar…

And a new EPA anti-inflammatory mechanism/target: New study shows EPA is a potent physiological blocker of #VNUT (vesicular nucleotide transporter) that potently alleviates neuropathic and inflammatory pain & insulin resistance. pnas.org/doi/full/10.1073/pn… nutritioninsight.com/news/be…

Interestingly, new paper by Gregory Shearer et al suggests EPA/DHA activation of #Omega3 sensor #FFAR4 (GPR120) activates signaling that induces production of cytoprotective oxylipin 18-HEPE (Resolvin E1 precursor) leading to cardioprotective effects etc. journals.physiology.org/doi/…

Mechanistically EPA & DHA (and their concentration/product/dose/time dependent derivatives) work together synergistically via multiple mechanisms to reduce/resolve chronic inflammation. tandfonline.com/doi/full/10.… nitter.cf/npure3/status/13802236…

New umbrella review of 32 #Omega3 meta-analyses finds combined EPA/DHA supplementation significantly reduces serum levels of aging factors CRP, IL-6 & TNF. EPA & DHA in combination = more favorable effects on inflammatory biomarkers than EPA or DHA alone. sciencedirect.com/science/ar…

#Omega3's for an active brain: New study shows DHA as a powerful activator of #Antiaging transcription factor PPARα in the brain (via DHA-derivative 7(S)-HDHA) suggesting that this DHA derivative supports & enhances neuronal synaptic capacity in the brain. science.org/doi/10.1126/scis…

New important @Nature study shows inhibiting inflammatory STING signaling represent a promising #Antiaging approach. Another recent important @Cell_Metabolism study showed #Omega3 fatty acids as crucial STING inhibitors/regulators. cell.com/cell-metabolism/ful… nitter.cf/Nature/status/15422112…