Otilia Ciobanu (@oticiobanu) profile picture
Romania
Joined July 2015
Photo by Otilia Ciobanu (@oticiobanu)Photo by Otilia Ciobanu (@oticiobanu)Photo by Otilia Ciobanu (@oticiobanu)Photo by Otilia Ciobanu (@oticiobanu)Photo by Otilia Ciobanu (@oticiobanu)Photo by Otilia Ciobanu (@oticiobanu)Photo by Otilia Ciobanu (@oticiobanu)
Otilia Ciobanu retweeted
I struggle with this. We are living in the era of precision oncology: better biomarkers, better patient selection, and an increasing effort to identify who actually benefits from a treatment. Yet here, the direction seems almost the opposite: tumour-agnostic reimbursement of dual IO, essentially “give it to as many patients as possible.” Shouldn’t precision oncology mean more selection, not less? Especially when broader treatment means broader exposure to toxicity and cost, while the incremental benefit over PD-(L)1 alone remains uncertain in many of these settings. Precision medicine should be about finding the right patient not the largest possible population.
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Virtually walking the halls at #ASTRO2026 as a medical oncologist, I keep coming back to the same thought: radiation oncology is quietly rewriting what “definitive local therapy” can look like. The unveiling of Accela from @SiemensHealthineers is more than another linac. Single-breath-hold SBRT, multi-site treatments in ~60 seconds, imaging-to-beam-off in under 90 seconds. Speed that actually changes biology and logistics, not just throughput. Patients spend less time on the table. Targets have less chance to move. Adaptive workflows become practical rather than aspirational. What strikes me most as a simple.medonc is the accumulating evidence that SBRT is matching surgery in more and more settings: early lung cancer, localized prostate (PACE-A data here this week), selected oligometastases, small HCC. Every time we add a tumor type to that list, we spare someone anesthesia, a wound, weeks of recovery, and the cascade of complications that still follow even “minimally invasive” operations. Surgery will always have its place. But the risk-benefit conversation is shifting. For older, frail, or multi-morbid patients, the ones I see every clinic day, the non-invasive option is no longer a consolation prize. It is often the more thoughtful one. The field is not just getting more precise. It is getting faster, smarter, and more humane. That is worth paying attention to, even from the medical oncology side of the hallway. Well done my fellow radoncs!!
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Submitting a manuscript is like applying to college, except you can apply to only one school at a time and must wait for its decision before applying elsewhere. Naturally, people start with their dream school. But after several rejections, enthusiasm can give way to discouragement. Rejection is the norm, especially at highly selective journals. Success is going from failure to failure without losing enthusiasm. Learn from the feedback, revise the manuscript, and submit again. A manuscript rejected by multiple journals can still be published, earn hundreds of citations, and change the field.
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Otilia Ciobanu retweeted
Replying to @DGlaucomflecken
@DGlaucomflecken wants to jail students for low-impact case reports and padding CV. Though most of us agree that this is likely effective and practical, there are legal concerns Jailing med students for p-hacking a 3-patient retrospective review is wildly unconstitutional. (1/n)
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Proton therapy theoretically has better dosimetry than photon therapy for prostate cancer. ☢️ So did it actually lead to better outcomes? We review the history, physics, and clinical trial outcomes. youtu.be/gu8Ekd5mTbw
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The amount of serious discourse I seem to have kicked off the last couple days is pretty wild. Nobody is banning med student research. Come on people. Clearly compulsory med student research is a big problem though. Should it be illegal, resulting in jail time? No, 3 days on the vascular surgery service should suffice. Btw, the jail thing was a joke. I hate clarifying jokes, but I’m genuinely concerned about the well being of some of my biggest PhD haters.
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Otilia Ciobanu retweeted
Seriously, I do not understand the ‘pure clinician’ vs ‘health researcher’ animosity 🤦🏼‍♂️*Each* is nearly *useless* without the other 😔Every whiff of this contrived rivalry undermines trust in all medicine ⚕️🩺 SAME👏🏼. TEAM 👏🏼. PEOPLE 👏🏼. ❤️‍🩹
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Otilia Ciobanu retweeted
There is almost no better way to build/demonstrate critical thinking skills than high-quality research. There is also almost nothing that gives people a false sense of having critical thinking skills than low-quality research.
Replying to @VPrasadMDMPH
We shouldn’t ban it. But we should encourage mastery of clinical skills and critical thinking over research in medical school. Selection to residency should favor this over research. Medical school is not graduate school. Its purpose is to train competent doctors
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Otilia Ciobanu retweeted
I love how oncologist will give highly toxic drugs for a PFS benefit of like 2 months but scoff at the idea of radiation therapy which can do usually the same if not better for 1% the cost and toxicity.
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It is not a biologically interesting question. But it matters to the patients, so it matters to me. Patients on the bladder empty arm are volunteering to give testimonials—they love it. Some patients in f/u from pre-trial era are donating to the cause.
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Otilia Ciobanu retweeted
Such a negative trial for so positive of a particle
🧵 Just published in @TheLancet: TORPEdO – the first phase 3 RCT designed specifically to test whether IMPT (proton beam) improves late function & QoL vs modern IMRT in oropharyngeal SCC. Short answer: It doesn’t. Long answer (with the numbers that matter) 👇
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What it looks like when #radonc uses a stethoscope nitter.cf/JustTheFights4/status/…
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Talking about #burnout helps create culture change that leads to a better environment for all. Grateful to Dr @d_golden for sharing @IJROBP for publishing redjournal.org/article/S0360… "practicing common humanity through public disclosure seems more important than career advancement"
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Otilia Ciobanu retweeted
Applications are now open for the Multidisciplinary Course on Oncology for #MedicalStudents. 📅 24-28 August 2026, Linz, #Austria. Jointly organised by @ESOncology, @ESSOnews, @ESTRO_RT, and @ESP_Pathology, it is designed to inspire and prepare the next generation of #cancer specialists. 🔬 Pre-course lectures with live Q&A, expert plenaries, case presentations, clinical visits, and group projects. Participants will gain a broad understanding of major cancers, including gastrointestinal, breast, lung, gynecologic, and genitourinary. 📌 Application deadline: 30 April 2026 👉 bit.ly/CourseMedicalStudents
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Otilia Ciobanu retweeted
Let’s play a little game. Let’s say that you’re the CSO at a cancer pharma company, and you have to choose a target to go after. Here’s a gene – high expression is associated with poor prognosis in brain cancer. Looks like a good candidate for an inhibitor right?
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Otilia Ciobanu retweeted
This piece has received a *criminal* lack of attention on here. Despite the moral panic about social media for teens, the data suggests our efforts to improve teen mental health would be better spent on banning SCHOOL. a few (of the many) interesting insights in this piece:
A vast array of data suggests that school, not social media, is the biggest modern threat to the mental health of children. If you were recently a child, that won’t be a surprise. If not: link in 🧵
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Otilia Ciobanu retweeted
Here's some quick improvements for this manuscript: 1) In the "plain language" summary, we catch a glimpse of the total study population - scientifically stated as "over 1,200 patients" 2) Of those "over 1,200 patients", 321 presented with "late complications". So, ≤26% of the total population were considered in this study. 3) Half of this subgroup had surgery first. 4) Of this 321-patient subgroup, 131 patients required hospitalization. So, ≤10% of the total population required hospitalization. Extrapolating further, ≤5% of patients receiving radiotherapy without surgery required hospitalization. That would be a more accurate calculation for the abstract/conclusion/discussion. (This isn't even considering the study data showing patients receiving primary RT were significantly older and had higher comorbidity burdens. The primary RT group also presented with more advanced disease. As such, observations in the primary RT group could simply reflect the inherent fragility and disease severity of that cohort rather than a treatment-specific effect.)
As editor-in-chief of @EurUrolOncol I would be happy to offer the possibility to comment, feed the debate and discuss within the journal @ESTRO_RT @Uroweb
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Otilia Ciobanu retweeted
Pro tip: If you're going to use Gemini to make infographics, you'll want to practice and experiment with it before putting something out in the world... Unless you love unintentional comedy.
MUST READ for urologist and radonc! Real world data on late GU toxicity after radiotherapy for prostate cancer Short term is underestimation of the real burden for the patient. Important when counselling patients for decision making. @aleantonellibs1 @RicBertolo
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Otilia Ciobanu retweeted
📣 We're #hiring a #PhD student! - Innsbruck - computational - 3 years - fully funded - Deadline: Feb 11th 💼 Project: scRNA-seq analysis on in-house developed cancer atlases 🔍 Looking for: candidate with experience in cancer and R/Python
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Applications are now open for the Stanford course on neural #assembloids! Deadline: December 12
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