Structural Biology & Genome Integrity @ CNIO
Madrid, Spain
Joined July 2014
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- Following1.3K
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Rafa F Leiro retweeted
🧬 How do bacteria open a molecular ring to start DNA replication?
Excited to share our new work in NAR @OxUniPress, where we reveal how the ancestral helicase loader DciA opens the bacterial replicative helicase DnaB.
@CIB_CSIC
academic.oup.com/nar/article…
🧵👇
Rafa F Leiro retweeted
Today, our work in partnership once again with @SternbergLab presenting the structures of several DRT10 bacterial defense systems and comprehensive analysis of their mechanisms of action is published… very happy!
Great work guys!
nature.com/articles/s41586-0…
Rafa F Leiro retweeted
starting to understand the structural bases of CONCR lncRNA in DNA replication and chromatid cohesion. A collaboration between @MaiteHuarteLab @FMorenoHerrero @OscarLlorcaCNIO @ChillonIsabel and the support of @FundlaCaixa
Online Now: CONCR lncRNA organizes a 3′-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion dlvr.it/TVD6XG
Rafa F Leiro retweeted
New paper in @MolecularCell! A great collaborative effort to uncover how the lncRNA CONCR works. Terrific teamwork with the labs of @MaiteHuarteLab @OscarLlorcaCNIO @ChillonIsabel and supported by @FundlaCaixa cell.com/molecular-cell/full…
Rafa F Leiro retweeted
Here one simple movie of the first complex Eco1-DRT10:
The RNA presents a unique conformation that resembles a 8 shape generating a pseudo-symmetric configuration. The 8 shape host inside a protein dimmer with catalytic pockets facing the outside.
Rafa F Leiro retweeted
✅ Galegos tiñan que ser‼️Parabéns‼️ 👉El @CNIO busca fármacos para desenmascarar a la proteína que esconde al melanoma del sistema inmunitario - lavozdegalicia.es/noticia/so…
Rafa F Leiro retweeted
The power of collaboration: Jose A Torres in my lab will be validating in vitro and in vivo a series of minibinders generated by a clever customized AI platform of @rfleiro group. This @ERC_Research PoC will also assess patentability and exploitation routes for the resulting IP
Rafa F Leiro retweeted
✅ Una medida excelente, que se venía demandando por todos aquellos que en algún momento participamos en paneles de evaluación del Programa RyC. @ASEICAnews @CienciaGob @ciccancer
Rafa F Leiro retweeted
Our latest manuscript is finally out in @NatureSMB!
Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels.
nature.com/articles/s41594-0…
Rafa F Leiro retweeted
#cibjoboffer
Postdoctoral candidate to collaborate on a project that aims to understand the pathophysiology of mitochondrial disorders.
Deadline: February 28, 2026
More info 👇
Rafa F Leiro retweeted
Revista SEBBM 227 diciembre 2025
Dinámica conformacional del receptor GluA4: bases moleculares de su función y modulación por TARP-γ2
f.mtr.cool/dkxkjjxncf
@BeatrizHergued1
Rafa F Leiro retweeted
Very happy to share a new preprint from my work in the @VanniniLab at @humantechnopole! biorxiv.org/content/10.64898…
If you are curious to understand what are the conformational changes that make human condensin II active in compacting the DNA during mitosis, have a read!
Rafa F Leiro retweeted
Our REPAIRome study finally out today in @ScienceMagazine !!!
science.org/doi/10.1126/scie…
Rafa F Leiro retweeted
Congratulations to all the people involved, also in @ChromDyn @rfleiro @gjmacintyre labs @CNIOStopCancer
Specially leading authors @ErnestoLDA1811 Israel Salguero and @DanielGLL_
Very proud of you!!!
Rafa F Leiro retweeted
🧬The human repairome, REPAIRome, will allow researchers around the world to check out how each of the 20,000 human genes affects DNA repair.
Authors: @CortesLab @ErnestoLDA1811 Israel Salguero Daniel Giménez et al.
Funding: @CienciaGob @AgEInves @Europarl_ES
Rafa F Leiro retweeted
Researches at #cniostopcancer create the ‘human repairome’, a catalogue of DNA ‘scars’ that will help define personalised cancer treatments.
Published in @ScienceMagazine
bit.ly/4fGk4CV
Rafa F Leiro retweeted
Our GPUs are always busy processing cool cryoEM data❄️, but we *really* wanted a to mess around designing protein binders.
To avoid swamping our cluster (and our colleagues complains 😅), we built a small batch-based binder design pipeline.
Hopefully you'll find it useful too!
We present BinderFlow, a modular & automated pipeline that makes de novo protein binder design more accessible, efficient, and user-friendly.
Preprint by @Nayimcete, Twitterless Carlos, @LlorcaLab, and myself:
biorxiv.org/content/10.1101/…
Open source code:
github.com/cryoEM-CNIO/Binde…
We present BinderFlow, a modular & automated pipeline that makes de novo protein binder design more accessible, efficient, and user-friendly.
Preprint by @Nayimcete, Twitterless Carlos, @LlorcaLab, and myself:
biorxiv.org/content/10.1101/…
Open source code:
github.com/cryoEM-CNIO/Binde…
BinderFlow is fully modular:
- Swap in new backbone generators, sequence designers, or scoring tools
- Add new strategies as they emerge
We illustrate this with two refinement approaches:
- Partial Diffusion
- Sequence Diversity
We hope BinderFlow empowers more labs to explore generative protein design, making it a routine tool for both exploratory & production-level research.
Everything is open source:
github.com/cryoEM-CNIO/Binde…
Read the full preprint here:
biorxiv.org/content/10.1101/…
