Robin Y Smith retweeted
If I were part of the Anthropic bio deal team, I would focus next on companies that have access to large amounts of diverse multi-omics patient data, ideally pre- and post-treatment, and beyond oncology (rare though!)
Robin Y Smith retweeted
Stanford Medicine scientists have developed TIGRa, an ultrasmall gene activator that could advance gene therapy for retinal degeneration and help prevent vision loss. stan.md/4xmwlo5
AI titan Anthropic has launched a biology ‘wet lab’ where human scientists and AI agents will work together to design and conduct experiments. The company has released one of the team’s first finds: a peculiar pattern of DNA in the genomes of several giant viruses.
go.nature.com/46K4qmC
Robin Y Smith retweeted
the FDA just approved the first ever treatment for sanfilippo syndrome, the genetic disease people call childhood dementia it's a gene therapy. we're rewriting the code now
Robin Y Smith retweeted
Lots of calls for "slowing down"... why aren't the labs calling for a 10x or 100x increased effort in ALIGNMENT work? After all, that is the core issue. ASI that is fully aligned with humanity uplifts everyone.
Robin Y Smith retweeted
1/ I'm a cardiologist. I've practiced for twenty-five years, through a lot of "breakthroughs" that turned out to be press releases. So understand the weight of what I'm about to say: I have never seen a single week in medicine like the one we just lived through.
In the span of a few days, four separate scientific breakthroughs landed. The stock market treated them as four unrelated stories and sent a handful of biotech companies soaring. But that's the shallow read. Look closer and they are not four stories at all. They are four faces of the same story — the biggest shift in medicine since the discovery of antibiotics.
Medicine is becoming programmable. Individualized. Written for one human being instead of the average of millions.
Let me walk you through exactly what happened, in plain language, and show you where this is actually headed. Because the future arrived quietly this week, and most people scrolled right past it.
Robin Y Smith retweeted
Anthropic engineer:
"You're not supposed to prompt Claude. You're supposed to build a system that prompts itself."
In 45 minutes she shows exactly how Anthropic builds agents that remember, fix their own mistakes and get smarter with every run.
This beats any paid course on agents I've seen.
Watch it, then read the guide on building loops below.
Robin Y Smith retweeted
founders are unstoppable when they master:
distribution + AI/agents + business/field + sharp systems
gives you near total control over destiny
bootstrap vs backed becomes a scale decision
Robin Y Smith retweeted
If you spend JUST one hour per day actually using AI to build something real, within 90 days you will be in the top 1% of people who understand what is happening. The bar is still shockingly low.
Robin Y Smith retweeted
Unclear if a durable trend, but CEOs and CTOs are back to coding with a fury, thanks to coding agents.
I have public company CEOs sliding into my DMs (and “InMail”) telling me about falling in love with shipping software again thanks to Claude Code and Vercel.
“Dream accounts” that we always wanted to work with, where in the past the C-suite would hardly understand the infrastructure until much later in the game.
Coding agents are the ultimate PLG-fication of the enterprise. Bad, legacy software can’t hide anymore. The stack that works is self-evident to the entire organization, from intern to CEO.
Robin Y Smith retweeted
The companies that win the next decade will be AI-native.
They won’t just use AI. They'll be built on it.
linkedin.com/pulse/ai-native…
Robin Y Smith retweeted
i come from a programming background, so i didn’t have strong physics/engineering mental models for biology
inspired by the Quant Bible from MIT, i created an equivalent for engineering in biology
it’s not deep but has been helpful for me
link: drive.google.com/file/d/1Ye4…
The thesis is simple: the future belongs to individuals who build compounding AI systems, not to individuals who use corporate-owned centralized AI tools.
I'm trying to build these in open source so you can have them for free. That's what GBrain is.
Robin Y Smith retweeted
Introducing Pods
Hyperspace Pods lets a small group of people - a family, a startup, a few friends, to pool their laptops and desktops into one AI cluster. Everyone installs the CLI, someone creates a pod, shares an invite link, and the machines form a mesh. Models like Qwen 3.5 32B or GLM-5 Turbo that need more memory than any single laptop has get automatically sharded across the group's devices - layers split proportionally, inference pipelined through the ring. From the outside it looks like one OpenAI-compatible API endpoint with a pk_* key that drops straight into your AI tools and products. No configuration beyond pasting the key and changing the base URL.
A team of five paying for cloud AI burns $500–2,000 a month on API calls. The same team's existing machines can serve Qwen 3.5 (competitive on SWE-bench) and GLM-5 Turbo (#1 on BrowseComp for tool-calling and web research) for free - the hardware is already on their desks. When a query genuinely needs a frontier model nobody has locally, the pod falls back to cloud at wholesale rates from a shared treasury. But for the daily work - code reviews, refactors, research, drafting - local models handle it and nobody gets billed. And when it is idle, you can rent out your pod on the compute marketplace, with fine-grained permissions for access management.
There's no central server involved in inference. Prompts go from your machine to your pod members' machines and back: all of this enabled by the fully peer-to-peer Hyperspace network. Pod state - who's a member, which API keys are valid, how much treasury is left - is replicated across members with consensus, so the whole thing works on a local network. Members behind home routers don't need port forwarding either. The practical setup for most pods is three models covering different jobs: Qwen 3.5 32B for code and reasoning, GLM-5 Turbo for browsing and research, Gemma 4 for fast lightweight tasks. All running on hardware you already own.
Pods ship today in Hyperspace v5.19. Model sharding, API keys, treasury, and Raft coordinator are all live.
What Makes This Different - No middleman. Your prompts travel from your IDE to your pod members' hardware and back. There is no server in between reading your data.
- No vendor lock-in. Pod membership, API keys, and treasury are replicated across your own machines using Raft consensus. If the internet goes down, your local network keeps working. There is no database in someone else's cloud that your pod depends on.
- Automatic sharding. You don't configure layer ranges or calculate VRAM budgets. Tell the pod which model you want. It figures out how to split it across whatever hardware is online.
- Real NAT traversal. Your friend behind a home router with a dynamic IP? Works. No VPN, no Tailscale, no port forwarding. The nodes handle it.
- Free when local. This is the part that matters most. Cloud AI bills scale with usage. Pod inference on local hardware scales with nothing. The marginal cost of your 10,000th prompt is the electricity your laptop was already using.
Coming soon:
- Pod federation: pods form alliances with other pods.
- Marketplace: pods with spare capacity can sell inference to other pods.
Readers added context they thought people might want to know
Hyperspace Pods is not yet available for installation or use, as there are no mentions of it, model sharding, or related features in the official documentation, website, or CLI repository. hyper.space github.com/hyperspaceai/a… github.com/hyperspaceai/a…
Robin Y Smith retweeted
BREAKING: Scientists just injected a Parkinson's patient with neurons grown from their OWN skin cells.
No immune drugs. No donor. No rejection.
12 months later — the cells are ALIVE, producing dopamine, and patients are moving better.
This is a thread you need to read 🧵👇
🔗 SOURCE: Aspen Neuroscience Press Release — March 18, 2026
aspenneuroscience.com/aspen-…




























