@ZuckerSOM M3, @SarnoffCardio Fellow ‘23-25. Enthusiast of science, good cooking, and bad puns.
Philadelphia, PA
Joined December 2020
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Now out in @JAMA_current: How well do individual risk estimates from different CHD polygenic scores agree? Grateful to work on this with a dream team of mentors and co-authors @damrauer @MGLevin @bpasaniuc @MarylynRitchie @dokyoon_kim @bvoight28 @BoulierKristin @karlkeat
🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star @SarnoffCardio fellow @sabramowitz_:
jamanetwork.com/journals/jam…
Sarah Abramowitz retweeted
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. #AHA24
ja.ma/3Od7BtF
ALT Figures 2B and 2C from the JAMA Original Investigation "Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores"
Sarah Abramowitz retweeted
@GenPrecisionMed ECC council was honoured to be judging such an incredible group of cardiovascular genetic researchers! 🫀🧬Congratulations to all the speakers - it was truly GPM research with impact and real world applications! Can’t wait for next year! #AHA24 @AHAMeetings
Sarah Abramowitz retweeted
Excited for these trainee presentations from the lab at @AHAMeetings #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!
Sarah Abramowitz retweeted
Are you an MD student interested in research?
Would strongly consider applying for the @SarnoffCardio Fellowship. Scientific immersion with *unparalleled* longitudinal mentorship & exceptional peer network career-long. sarnofffellowship.com/
My biggest regret in med school was not participating despite guidance from mentors. Now I'm thrilled to join this vibrant community on the Scientific Committee.
Nice summary of the program ahajournals.org/doi/10.1161/… @CircAHA
Track record of successful physician-scientists going through this program is impressive - the recipe of immersion + longitudinal engagement/sponsorship/mentorship works very well
Sarah Abramowitz retweeted
Do the multiple existing PRSs offer reliable individual-level assessment of disease risk❓
👉48 PRSs for coronary artery disease
👉comparable population-level calibration and discrimination
❗️wide variance in individual-level risk depending on PRS
🔗medrxiv.org/content/10.1101/…
Sarah Abramowitz retweeted
Our Story is Out - on BioRxiv! Humbled to have worked with such a great team of scientists to investigating how #SGLT2 inhibitors provoke their astounding cardiac benefits.
We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.1101/…
Sarah Abramowitz retweeted
8/ Our findings raise important practical questions about the clinical implementation of PRS:
- When PRS from two different sources disagree, which should we believe?
- How should we counsel patients about uncertainty?
- Can CAD PRS be individually useful given these limitations?
Sarah Abramowitz retweeted
1/ Excited to share this preprint from all-star @SarnoffCardio fellow @sabramowitz_, studying population- and individual-level performance of coronary artery disease polygenic risk scores, co-mentored with @damrauer.
Population Performance and Individual Agreement of Coronary Artery Disease Polygenic Risk Scores medrxiv.org/cgi/content/shor… #medRxiv
Sarah Abramowitz retweeted
Our paper "Temporal dynamics of the multi-omic response to endurance exercise training" was just published in @Nature! nature.com/articles/s41586-0… This extensive resource on the molecular map of the cross-tissue response to exercise is the result of a massive team effort! 1/
Sarah Abramowitz retweeted
.@sabramowitz_ shares work describing the variability in risk predicted by coronary artery disease polygenic risk scores that she is leading as a @SarnoffCardio Fellow in the lab of @damrauer and @MGLevin. @PennVascular @PennCVI @PennCardiology
Still buzzing from an incredible weekend at #ACC23! 🫀
Grateful for mentorship from Dr. Azari, support from @ZuckerSoM, and the opportunity to connect with and learn from so many amazing people from @NorthwellHealth cardiology, @Northwell_IM, and beyond.
A highlight was presenting a case of a giant coronary artery aneurysm leading to a diagnosis of Loeys-Dietz syndrome
abstractsonline.com/pp8/#!/1…
Grateful to have had such an awesome team of lab neighbors! Thanks for welcoming me to join in and learn from you all 🧬
It was great to have co-lab meetings w the Wheeler lab’s Sarah Abramowitz and will look forward to her progress in medical school! @euanashley
