188 inhibitors across 210 #kinases. A product of #openscience, inspiring the discovery of pioneer medicines
Chapel Hill, NC
Joined May 2015
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Best Kinase Inhibitor Set. Ever. retweeted
Cheryl announcing #Target2035 webinar series at today’s kick-off meeting. Looks exciting! @CherylArrowsmi1
Best Kinase Inhibitor Set. Ever. retweeted
A group of us around the world are creating an #openscience non-profit to invent drugs explicitly to put on the shelf for the next pandemic. We started the project last summer, but should have started a decade ago…damn. Announcement this week or next. @thesgconline
Best Kinase Inhibitor Set. Ever. retweeted
Researchers at @UNCpublichealth are testing an antiviral drug that shows promise as a possible treatment for COVID-19. #UNC’s Ralph Baric heads the lab developing the broad-spectrum antiviral that could potentially provide relief to the global pandemic unc.live/2ISOsM0
Best Kinase Inhibitor Set. Ever. retweeted
Discover a new #Kinase Chemogenomic Set from @therealKCGS ximbio.com/reagent/157681/th… #datasheet #lifesciences #reagents #inhibitors
Best Kinase Inhibitor Set. Ever. retweeted
Proud to announce today an expansion of our partnership with @ChordomaFDN to accelerate drug discovery in an open-source way! CC: @dhdrewry @UNCPharmacy @ICR_London @PaulWorkmanICR @thesgconline chordomafoundation.org/lates…
Best Kinase Inhibitor Set. Ever. retweeted
Together with @TheMarkFdn, we are proud to announce a two-year, $1.4M grant to researchers @PaulWorkmanICR @dhdrewry @Ogileadi focused on creating the first drugs capable of targeting #brachyury, the Achilles’ heel of #chordoma chordomafoundation.org/lates…
Best Kinase Inhibitor Set. Ever. retweeted
ICYMI: Check out the Kinase Chemogenomics Set (KCGS): 187 inhibitors for 215 kinases. A collaborative resource meticulously developed & curated by the SGC-UNC team. thekcgs.com/ More details here on @biorxivpreprint biorxiv.org/content/10.1101/… #openscience
Best Kinase Inhibitor Set. Ever. retweeted
#DYK: the first Structural Genomics Consortium lab to operate in the US is located in #UNCPharmacy? Thanks to support from the Eshelman Institute for Innovation, Tim Willson & his team's research is placed in the public domain for use, no strings attached bit.ly/2tOTGo5
Best Kinase Inhibitor Set. Ever. retweeted
Take a look to see publications from labs using our community generated chemogenomic sets. #KCGS #RandomActsOfKinase One reason we share compounds is the diversity of experiments they end up in @thesgconline @therealKCGS #kinase sgc-unc.org/kcgs-and-pkis-pu…
Best Kinase Inhibitor Set. Ever. retweeted
Preprint alert. A “target engagement” and kinetic survey of 46 CDK inhibitors against all members of the CDK family in living cells. Well done Carrow, Kilian, Matt and colleagues! @promega @thesgconline @DruggableGenome @therealKCGS @chembiohub
chemrxiv.org/s/2d4ff757c44f3…
Best Kinase Inhibitor Set. Ever. retweeted
New Product launch today - Discover a new #Kinase Chemogenomic Set from @therealKCGS ximbio.com/reagent/157681/th… #datasheet #lifesciences #reagents #inhibitors
Best Kinase Inhibitor Set. Ever. retweeted
Excited to see out this fantastic collaboration with @CowenLab and @thesgconline to validate Yck2 kinase as a promising therapeutic target to overcome fungal Echinocandin resistance!! @CellChemBiol
cell.com/cell-chemical-biolo…
Best Kinase Inhibitor Set. Ever. retweeted
KCSG now available! The smallest number of kinase inhibitors to tickle the most kinases. It's the metadata that make this set so useful. Contributions from many awesome scientists in pharma and academia. @thesgconline
The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification biorxiv.org/cgi/content/shor… #bioRxiv
Best Kinase Inhibitor Set. Ever. retweeted
Tim Willson @timwillson from SGC-UNC @UNCPharmacy opens @tfri_research symposium on Cancer targets & emerging therapies describing the #openaccess kinase chemogenomics set @therealKCGS. Any researcher who agrees to #openscience can order the set sgc-unc.org/kcgs
Best Kinase Inhibitor Set. Ever. retweeted
Wanna do Alzheimer's open drug discovery? Join Open-AD team @thesgconline @UNCPharmacy. Promising drugs will be developed with no patents by @m4ndpharma, and priced to allow access by all. Business model pioneered by @DNDi & applied in pediatric oncology by @M4KPharma. @MSF
Positions now available @UNCPharmacy to discover drugs for Alzheimer’s disease using open science. Med Chem unc.peopleadmin.com/postings… Assay Dev unc.peopleadmin.com/postings… Comp Chem unc.peopleadmin.com/postings… #Open-AD #FryeLab #SGC-UNC #OpenScience
Best Kinase Inhibitor Set. Ever. retweeted
As of Aug. 2019, >25,000 samples of @thesgconline #chemicalprobes have been distributed to scientists without restriction. They're referenced in >4,000 papers. The resulting science has seeded countless biotechs & drug discovery programs. #openscience: the gift that keeps giving!
Best Kinase Inhibitor Set. Ever. retweeted
Jacob McAuley @thesgconline purifies more proteins that may interact with huntingtin: bit.ly/31FAfJJ @HuntingtonSC @HDSA @HDBuzzFeed @HDAwareness
Best Kinase Inhibitor Set. Ever. retweeted
Our latest chemical probe, an inhibitor for NSD2-PWWP1 and control cmpd, available ahead of publication now! This #openaccess reagent was created in collaboration w/ scientists from CICBDD @UNCPharmacy thesgc.org/chemical-probes/U… #OpenScience #epigenetic
Best Kinase Inhibitor Set. Ever. retweeted
📢SAVE-THE-DATE: We're hosting an #OpenScience Symposium at The Neuro on Monday, November 18, 2019!
Best Kinase Inhibitor Set. Ever. retweeted
Fascinating visit to @ARUKnews Oxford Drug Discovery Institute today - a brilliant example of how collaboration in dementia research is fast-tracking development of new treatments. #MakeBreakthroughsPossible
