@vruta007

Chem PhD student at ICT Mumbai (2025-). BS-MS @IISERPune (2022). Process dev for biomass to fuel. Interested in #synbio Ex plant biochem/ enzyme engg

Mumbai
Joined November 2018
East coast is the yeast coast
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A brief story on why this is wrong-headed and doomed to fail: My lab is currently studying the regulation of a gene. We think the gene is doing a surprising amount of stuff, and it has some regulatory features that we are interested in from prior work. 1/11
If we want to unlock biological engineering we need to kill the manual lab bench. I've tried almost everything else over the last 20 years😛and PhDs still having to be in the lab is the rate limiter.
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Vruta Gupte retweeted
senior phd student in our group has spent over two years doing fundamental research of a complex metal-support interaction of noble metals at high temperatures. Submitted to physical review letters both reviews came back as claudeslop
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Vruta Gupte retweeted
This is my data. Measuring Protein-Protein interaction with a colorimetric readout 🎨
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Super excited to share that my Master's thesis (from my alma mater IISER Pune) in collaboration with IIT Bombay and IACS Kolkata has been published online. Even more exciting is the fact that it's my first - first author paper!!! Check it out on doi.org/10.1021/acs.orglett.…
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Vruta Gupte retweeted
1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
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Vruta Gupte retweeted
I've written 70+ recommendation letters for students applying graduate programs in my career. This is the saddest one I have to redo. // A former undergrad student got denial of entrance with a 5-year ban, when flying to the US for PhD study. As usual, no reason was given. I can't imagine what he have gone through.
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The IISER Mohali administration has withdrawn this.
As we speak of protests in IISER Pune, IISER Mohali is making students sign that they will never sit in protest and that they're not suffering from mental illnesses at the time of admission.
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Bioproducts are my whole job. I have a PhD in systems biology. I am toxically online. I follow the peptides and GLP-1 markets with sustained professional interest. I do not know what "rip a peptides offer" means. Does it mean sell peptides? Is that how kids say sell?
You could rip a peptides or GLP-1 offer right now, and make $30M profit in <12 months Instead you work a job making $300k/yr. That's 100 years of salary. Why are you still working anon?
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U.S. students hoping to earn a Ph.D. in political science, public policy, cultural anthropology, or science education will no longer be eligible for a prestigious fellowship from the National Science Foundation, the agency has revealed. @ScienceCareers scim.ag/4qYcyJz
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Vruta Gupte retweeted
Please check our new work on CAAO supported disilene just out in @ChemCommun Many congratulations to @RajaKumarGaurav and many thanks to our all the collaborators 🙏
Extremely happy and pleased to share our latest work online in @ChemCommun. Special thanks to @ShabanaKhan01 for guidance, and many congratulations to @RishukumarP, @KumarVanka1, and Simranjeet. Please follow the link for more details: doi.org/10.1039/d6cc03694e
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Vruta Gupte retweeted
Cytokinin histidine kinase receptors regulate multiple aspects of rice growth and development (Eva Mei Shouse , Alejandro Aragón-Raygoza , Emily J Tallerday , et al) doi.org/10.1093/plphys/kiag2… @ASPB #PlantSci
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In economics, we call this submitting papers with a Cambridge zip code.
When you throw a ball at a wall, you can be sure it will bounce back at you. You would be extremely surprised if the ball suddenly appeared on the other side of the wall. In quantum mechanics this type of phenomenon is called tunnelling and is exactly the type of phenomenon that has given it a reputation for being bizarre and unintuitive. The 2025 Nobel Prize laureates in physics John Clarke, Michel H. Devoret and John M. Martinis, used a series of experiments to demonstrate that the bizarre properties of the quantum world can be made concrete in a system big enough to be held in the hand. Their superconducting electrical system could tunnel from one state to another, as if it were passing straight through a wall. They also showed that the system absorbed and emitted energy in doses of specific sizes, just as predicted by quantum mechanics. In a few weeks we will be announcing this year's Nobel Prize in Physics - stay tuned.
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So elegant! Very excited to read more about this. Beautiful work!
This is an incredible flower. It is engineered. To make it, you take a gene encoding a red pigment and insert a transposon into the middle of it. This transposon keeps the gene switched 'off.' As the flower develops, the transposon spontaneously "jumps" out of the gene in some cells, thus restoring the gene and enabling it to make the color red. Every red speck, then, is a cell where that jump happened, and all the white is cells where it didn't. This is, in short, randomness in biology made manifest. You can tinker with these transposons so that they jump more often or less often. You could also insert multiple pigment genes with transposons that jump at different rates to get entirely different patterns of colors.
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Vruta Gupte retweeted
How do DNA duplexes recognize and pair with each other? Thomas Catley, @VVBerrelleza, @alicepyne and myself present the first direct visualization of DNA-DNA pairing mediated by divalent cations, confirming the decade-old DNA zipper model! doi.org/10.1093/nar/gkag817
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I think this kind of behaviour needs to be called out and condemned. The review process is already burdened significantly, so submitting a paper you don't fully understand is asking someone else to do the work so you can get the credit.
I am guilty of this myself. I am about to submit an AI-derived mathematical proof to arXiv that I don't completely understand but which addresses a problem in theoretical biology with a neat solution. I understand the problem, the approach and the result, but I don't understand all the details of the proof. It's been an exciting experience that has occupied the better part of the last month for me. I am transparent about my limitations in understanding the proof and welcome human review that proves it right or wrong (you learn something important about AI in either case). In general, I consider it an entirely good thing for people who are not specialized to use AI for solving problems in their field using tools from other fields that they don't fully understand. But I agree that it is placing a serious burden on human verifiers. Unless, of course, the AIs become so good at verifying that we don't need humans.
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Vruta Gupte retweeted
the best way to describe being in academia at the moment is that it’s like knowing that you’re starring in a mockumentary
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deep learning is hitting a wall
china’s AI robot just hit 14.5 m/s
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Vruta Gupte retweeted
Reinventing “graduate student” from 1st principles
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Why are Indian researchers not talking about how much a single #NatureCommunications costs? @NatureComms @NatureInd
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