Martin Rey (@xmr128) header
Martin Rey (@xmr128) profile picture

Martin Rey

@xmr128

Chemical Biologist https://nitter.cf/t.co/VUdJLKHwKy Current: Postdoc in the Thorn-Seshold Group Before: PhD in the Trauner Lab

thornseshold.cup.uni-muenchen.de/
Joined April 2019
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Photo by Martin Rey (@xmr128)Photo by Martin Rey (@xmr128)Photo by Martin Rey (@xmr128)Photo by Martin Rey (@xmr128)
Just posted the most biologically important photopharmacology story we've had in the last few years. Ditched the photoswitch design principles we used for the last 10 years, & started all over again. And now it will work in vivo. doi.org/10.1101/2024.07.12.6… 🧵1/n🧵
Image from Thorn-Seshold Lab 🇺🇦 (@ThornSesholdLab)
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Check out our paper on Photoactivated Protein Degraders for the Optical Control of Synaptic Function. Great collaboration with André Fenton and his team @FentonLab. @NYU_CNS, @PennChemistry, @PennSysPharmATT, @PGGUPenn, @UPennPhysiology pubs.acs.org/doi/10.1021/acs…
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Great to see our work on PHOIMiDs - photoswitchable molecular glue degraders - as a preprint! This is the next hot thing after PHOTACs. Wonderful project with the legendary @chrisarp_, @Sreekanth_Vedas + @kokkonda2 at the @ChoudharyLab, @paganolab and @DirkTrauner.
Image from Martin Rey (@xmr128)
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Check out @biorxivpreprint if you want to learn about these tools for the selective degradation of Aiolos/Ikaros using light: biorxiv.org/cgi/content/shor…
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A Photoactivated Protein Degrader for Optical Control of Synaptic Function biorxiv.org/cgi/content/shor… #bioRxiv
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PHOTACs as neuroscience tools! More applications of PHOTACs to come...
Dirk H. Trauner (@DirkTrauner) profile pictureDirk H. Trauner
@DirkTrauner15 Feb 2023
Check out our collaboration with the @FentonLab on the optical control of synaptic function using a photoswitchable #PROTAC. Works in x,y, and z! @CG_JOU,@tongil_ko, @aa_fenton biorxiv.org/content/10.1101/…
A Photoactivated Protein Degrader for Optical Control of Synaptic Function

A Photoactivated Protein Degrader for Optical Control of Synaptic Function

Hundreds of proteins determine the function of synapses, and synapses define the neuronal circuits that subserve myriad brain, cognitive, and behavioral functions. It is thus necessary to precisely...

biorxiv.org
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Ultra Excited!! #Photopharmacology watches azoCA4 isomerise and undock from tubulin from the ps to the ms scale. Turn your volume up to 11 for this tribute video! #Photoswitch congrats to Wranik, Steinmetz & Standfuss: get the original @biorxivpreprint at doi.org/10.1101/2022.02.17.4…!
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Join us NOW to see the winners of the Basic Award!—Dieter Oesterhelt of @MPI_Biochem, Peter Hegemann of @HumboldtUni, and @KarlDeisseroth of @StanfordMed—for “light-sensitive microbial proteins and #optogenetics” laskerawards.live #Lasker2021 #LaskerLaureate #LaskerAward
Image from Lasker Foundation (@LaskerFDN)
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Happy to contribute a review together with @dirktrauner discussing strategies to control PROTACs using light and grateful for the invitation by @DeyMishtu and @DanNomura
Cell Chemical Biology (@CellChemBiol) profile pictureCell Chemical Biology@CellChemBiol10 Jun 2021
Online now! Optical control of targeted protein degradation dlvr.it/S1SRkJ #chembiol
Optical control of targeted protein degradation

Optical control of targeted protein degradation

This review compares the emerging approaches to control proteolysis targeting chimeras with light. Reynders and Trauner discuss the design challenges and outline future directions for the field.

cell.com
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The following link can be used to access the article for the next 50 days: authors.elsevier.com/c/1dDNc…
Interesting paper by the group of @DirkTrauner with first author @xmr128 in @angew_chem. A photoactivatable covalent kinase inhibitor for JNK3. Using a sign-inversion approach they obtained a design that switches on the covalent reactivity with the JNK3 cysteine upon irradiation.
Dirk H. Trauner (@DirkTrauner) profile pictureDirk H. Trauner
@DirkTrauner3 Jun 2021
Check out our new paper on arming a cysteine-reactive electrophile with light. Thanks to a collaboration with Stefan Laufer and Stefan Knapp. onlinelibrary.wiley.com/doi/… @goetheuni @uni_tue @nyuchemistry @photopharma_lit
Image from Dirk H. Trauner (@DirkTrauner)
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Check out our new paper on arming a cysteine-reactive electrophile with light. Thanks to a collaboration with Stefan Laufer and Stefan Knapp. onlinelibrary.wiley.com/doi/… @goetheuni @uni_tue @nyuchemistry @photopharma_lit
Image from Dirk H. Trauner (@DirkTrauner)
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Last week’s lecture by Ugur Sahin now online available: biochem2.com/embed/2021-02-0… @iDikic2 @goetheuni @merckgroup
Image from Ingo Hartung (@HartungIngo)
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Small molecules, antibodies, siRNA, oh my! Your guide to the 53 drugs approved in 2020: ow.ly/51Es50D8yMw
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Martin Rey retweeted
Trevor Bedford (@trvrb) profile picture
Trevor Bedford
@trvrb14 Jan 2021
After ~10 months of relative quiescence we've started to see some striking evolution of SARS-CoV-2 with a repeated evolutionary pattern in the SARS-CoV-2 variants of concern emerging from the UK, South Africa and Brazil. 1/19
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The @pfizer / @BioNTech_Group vaccine is based on the delivery of synthetic RNA to cells. How does this work? The chemistry behind RNA vaccines is explored in this graphic developed with @compoundchem #CovidVaccine #COVID19 #vaccination
Image from Royal Society of Chemistry (@RoySocChem)
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Life of Brine #ChemifyAMovieTitle
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PROTAC-DB: an online database of PROTACs pubmed.ncbi.nlm.nih.gov/3301…
PROTAC-DB: an online database of PROTACs - PubMed

PROTAC-DB: an online database of PROTACs - PubMed

Proteolysis-targeting chimeras (PROTACs), which selectively degrade targeted proteins by the ubiquitin-proteasome system, have emerged as a novel therapeutic technology with potential advantages over...

pubmed.ncbi.nlm.nih.gov
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PhotoPROTACs: A Novel Biotechnology for Cancer Treatment cell.com/trends/cell-biology…
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Check out this important article: Organic Chemistry: A Call to Action for Diversity and Inclusion | ACS Central Science pubs.acs.org/doi/10.1021/acs…

Organic Chemistry: A Call to Action for Diversity and Inclusion

By now, most of us in the field of organic chemistry have become aware of the recent Perspective Article by Hudlicky published on the Angewandte Chemie, In

pubs.acs.org
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