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Falleciรณ nuestra mamรก esta tarde. Asรญ la recordaremos, feliz por tenernos, y nosotros por tenerla. Siempre nos va a acompaรฑar.
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Si Citigroup dice que la caรญda no va ser profunda, apuesto por lo contrario.
๐ youtu.be/litMhgyoPjg?si=_hO0โฆ
Citigroup CEO Jane Fraser says she does not think this correction will run deeper or longer
"I don't think so. I think it's probably time for a market correction at some point"
"This is action taken by the hedge funds to de-risk"
"The demand behind AI is real... the genie is not getting put back in the bottle here"
Fraser said institutions and retail have been quieter than hedge funds in the unwind, and that AI demand is not going away in the next few years ($C $QQQ $NVDA)
When the CEO of one of the biggest banks on Wall Street says the correction should not run deeper, that is the tape talking through a bullhorn
via @CNBC, featuring @Citi
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Scientists make cancer cells manufacture their own poison @RIKEN_JP
What if cancer cells could be tricked into manufacturing the very drugs designed to kill them?
Scientists in Japan have developed an experimental strategy that does exactly that.
The research team, led by Katsunori Tanaka at RIKEN, used a chemical reaction to manufacture an anticancer compound inside cancer cells.
The trick involves carbon monoxide.
Cancer cells naturally produce carbon monoxide as part of their metabolism. Researchers wanted to exploit this difference to selectively activate a drug-producing reaction inside tumours.
Here is how it works.
First, scientists designed a palladium-based molecular catalyst.
They then protected it inside albumin, a protein that helps transport substances through the body.
Once inside cancer cells, the naturally available carbon monoxide activates a chemical reaction that produces phenanthridinone derivatives.
Some of these compounds have powerful cell-killing properties.
The researchers tested their approach in cultured human liver, cervical, breast and lung cancer cells.
They detected the newly manufactured compound inside cancer cells, but not in the non-cancerous cells used as controls.
In additional experiments, the resulting anticancer compound damaged liver cancer cells.
Why does this matter?
One of the biggest challenges in chemotherapy is delivering enough drug to destroy cancer without causing unacceptable damage to healthy tissue.
Instead of delivering the active poison directly, this approach attempts to manufacture it at the disease site.
The limitation is significant: these are laboratory experiments, not demonstrated cancer treatment in animals or humans.
But the underlying concept is fascinating โ using the chemistry of cancer cells as a trigger for manufacturing their own treatment.
[ Kawai M et al. Harnessing endogenous carbon monoxide for cancer-selective drug synthesis. Nature Communications. 2026. DOI: 10.1038/s41467-026-77616-8 ]
Ciclos
Dear everyone ๐
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OpenAI's Greg Brockman says AI could make death a choice and predicts significant progress toward curing diseases within the next 12 to 18 months.
Once science fiction, today reality. And yet, people oppose AI.
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Six melanoma patients received vaccines containing up to 20 personalized tumor neoantigen peptides. Four remained recurrence-free at 25 months. Two patients with recurrent disease subsequently experienced complete tumor regression after anti-PD-1 treatment.
doi.org/10.1038/nature22991
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Replying to @BatPitt
Cartalax targets chondrocyte gene expression, whereas BPC-157 accelerates systemic angiogenesis and soft tissue repair. Different pathways.
Replying to @vlatdd
You lot keep inventing miracles then using them to argue about nonsense. Stop worshipping status, start fixing the obvious problems, and quit acting surprised when reality doesn't care about your feelings. You're capable of extraordinary things. Act like it.
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๐จ "ุชุนุฑุถุช ููุถุฑุจ ุญุชู ูุฏุช ุฃู
ูุช.. ููููู ุงุฎุชุฑุช ุงูุชุณุงู
ุญ!".. ุญูุงุฑ ูุงุฏุฑู ูููู ุณูููููุฌูุฉ ุฅูููู ู
ุงุณู!
โ๐ฅ ูุต ุงูุญูุงุฑ ุงูุตุงุฏู
:
โโข ุงูุตุญูู: ูู ุตุญูุญ ุฃูู ุชุนุฑุถุช ููุชูู
ุฑ ูุฃูุช ุทููุ
โข ุฅูููู: ูุนู
ุ ูุฏุฑุฌุฉ ุฃููู ููููุช ููู
ุณุชุดูู ููุงูุช ุญูุงุชู ูู ุฎุทุฑ ุญูููู.
โข ุงูุตุญูู: ุฃูู
ุชุฑุบุจ ูู ุงูุงูุชูุงู
ู
ููู
ุจุนุฏู
ุง ุฃุตุจุญุช ุงูููุฉ ูุงูู
ุงู ุจูุฏูุ
โข ุฅูููู: "ุงูุนูู ุจุงูุนูู ุชุฌุนู ุงูุนุงูู
ููู ุฃุนู
ู.. ุงูุฑุฏ ุนูู ุงููุฑุงููุฉ ุจุงููุฑุงููุฉ ูุง ููุชุฌ ุฅูุง ู
ุฒูุฏุงู ู
ููุง. ุงูุงูุชูุงู
ูู ูุบูุฑ ุงูู
ุงุถูุ ูุฃูุง ูุง ุฃุฑูุฏ ุฅุถุงุนุฉ ููุชู ุนููู."
โข ุงูุตุญูู: ูู ู
ุงุฐุง ุชุฑูุฏ ุฅุถุงุนุฉ ููุชู ุฅุฐูุ
โข ุฅูููู: "ูู ุฌุนู ุงูู
ุณุชูุจู ุฃูุถู.. ุจูุงุก ุงูุณูุงุฑุงุช ุงูููุฑุจุงุฆูุฉุ ุงูุตูุงุฑูุฎ ุงูู
ุนุงุฏ ุงุณุชุฎุฏุงู
ูุงุ ูุฌุนู ุงูุจุดุฑูุฉ ุชุนูุด ุนูู ููุงูุจ ู
ุชุนุฏุฏุฉ."
ุฃุนุธู
ุงูุชูุงู
ูู ุงููุฌุงุญ ุงูุฐู ูุฌุนู ุงูู
ุงุถู ุฎูู ุธูุฑู ููุฃุจุฏ!
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BREAKING: New GLP-1 quadruple agonist drug from Celltrion beats Retatrutide by adding Amylin, a fullness imitator!
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Elon just teased SpaceX's next-gen V4 @Starlink satellites:
"Starlink version 4 will have 10x the capability of V3 (which itself is 10x better than V2), especially with the long-distance laser links. Our next-gen laser links will be 10-terabits per second. 100x better. And we'll put 10 of them on."
~100 lasers per satellite, each operating above 10 Tb/s, with over 100k satellites should be able to outcompete undersea cables.
Speed of light in space is ~40% faster than cable and the path is direct, instead of following the outline of land masses.
Elon just teased SpaceX's next-gen V4 @Starlink satellites:
"Starlink version 4 will have 10x the capability of V3 (which itself is 10x better than V2), especially with the long-distance laser links. Our next-gen laser links will be 10-terabits per second. 100x better. And we'll put 10 of them on."
CARTALAX vs BPC-157
cartalax does what BPC-157 and KPV JUST CAN'T DO - and there's actual human evidence behind it
BPC-157 works by building blood vessels into injured tissue. that's why it's so good for tendons, ligaments and joints.
BUT deep cartilage barely has any blood supply to build into. that's the unbridgable gap.
cartalax is three amino acids (AED), made in russia as a bioregulator for cartilage and connective tissue
in cell work it pushes chondrocytes, your cartilage cells, to grow, and lowers p53 so they stay alive instead of dying off.
and the "no human data" on cartalax was wrong.
it was just in russian.
slugina et al., 2015: elderly patients, jaw surgery, cartalax used around the operation. the authors followed bone regeneration clinically and on x-ray, and concluded it worked in older age groups.
so there's the human BONE data.
now letโs think about what it could actually do;
cartilage is the most annoying tissue of the body. no blood vessels, no nerves, and chondrocytes that barely divide.
thatโs why a worn knee can't just heal itself with time. thereโs no blood supply to bring in the right repairing agents.
BPC-157 leans hard on angiogenesis. it builds vessels into damaged tissue... but again, deep cartilage has nothing to build into.
KPV canโt fill that gap either. it shuts off NF-ฮบB and calms the cytokines that chew through cartilage matrix (IL-1ฮฒ, TNF-ฮฑ), but it never tells a chondrocyte to live or make new matrix.
cartalax goes after the cell itself. in cell studies it pushes chondrocytes to grow and lowers p53, the signal that sends them toward dying off.
the theory is simple: keep the few cartilage cells you have alive and dividing.
where that could matter:
worn knees and early osteoarthritis, where chondrocyte loss is the whole story.
spinal discs, which are also avascular and degrade with age. spinal osteochondrosis is one of the things the russian institute positions it for.
aging bone, since the jaw data shows regeneration moving in old patients.
recovery around joint surgery, which is another use they position it for.
& this is where the stack clicks together.
KPV puts out the inflammation. BPC rebuilds the soft tissue around the joint. cartalax tells the cartilage cells to stay alive.
three layers of the same joint, zero overlap.
is it proven for cartilage in humans? no... these days, fucking NOTHING good is.
but the mechanism is aimed at exactly the tissue the other two canโt reach, and thatโs what makes it worth watching.
not medical advice.
Slugina et al. 2015, Kubanskii Nauchnyi Meditsinskii Vestnik (DOAJ)
AI "bubble" vs Dot.com bubble. Would still have a 10x to go from here
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The first use of a senolytic immunotherapy in people!
Thankful for my team @immortabio
SenoMune-0257
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