Following lactate wherever it goes. | metabolism · mitochondria · heart · disease | @RWJMS | PI: @molecularpepsi
Piscataway, NJ
Joined July 2024
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📢 Very excited to share this review led by our talented postdoc Bhavya (@Bhavya391554759)!
Bhavya took a critical look at decades of lactate biology, asking what the evidence actually tells us and where our assumptions have gotten ahead of the science.
onlinelibrary.wiley.com/doi/…
Cluntun Lab retweeted
I first presented this story at @KeystoneSymp in Breckenridge in 2022.
@ZoltArany was skeptical. But he took the idea seriously.
Over the next few years, whenever we crossed paths, he kept challenging me on it. Those conversations helped me understand just how high the burden of proof would be to convince the field. The paper is better because of them.
Eventually: “You might be right.”
Four years later, @AranyLab’s Trace Thome and Zolt have written a thoughtful commentary on our paper. Apparently we’ve advanced to “dogma-defying.”
One day I might actually be right...
nature.com/articles/d41586-0…
Cluntun Lab retweeted
A tremendously collaborative effort led by co-first authors: @molecularpepsi (our amazing former postdoc), @joevisker, @jn_velascosilva, and James Carrington (our awesome grad student)!
Congrats to all authors, co-senior authors @gsducker and @StavrosDrakos, and everyone who contributed!
I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s41586-0… @UofUBiochem 1/10
Cluntun Lab retweeted
I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s41586-0… @UofUBiochem 1/10
Cluntun Lab retweeted
Jokes aside, this one means a lot.
It started when I was a postdoc, followed me into starting my own lab, and took a remarkable group of people to get across the finish line.
The question was simple: can lactate enter mitochondria?
Turns out, yes.
@RutterLab @StavrosDrakos @gsducker @joevisker @jn_velascosilva
Cluntun Lab retweeted
You can purchase the paper here:
Just kidding. We already paid @Nature so you don’t have to.💸
#OpenAccess
nature.com/articles/s41586-0…
Cluntun Lab retweeted
Folks, despite my best efforts, I regret to announce that I have published a paper in @Nature.
I can finally become one of those annoying PIs who tells trainees they don’t need a Nature paper to get a faculty job.
#blessed @mbeisen
nature.com/articles/s41586-0…
Before there was a Cluntun Lab, there was a question:
Can lactate enter mitochondria?
Today, years after that question first took shape, the answer is published in @Nature.
Yes. And MCT1 helps get it there.
nature.com/articles/s41586-0…
The work began at @UUtah and continued after the Cluntun Lab opened at Rutgers, with members of our new lab joining the effort.
Grateful for the support of @NIH and proud to continue building this work at @RutgersU and @rutgershealth.
Cluntun Lab retweeted
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
cell.com/cell/fulltext/S0092…
Cluntun Lab retweeted
Lactate is one of the most measured, yet most misunderstood, metabolites in biology. This BioEssays review revisits common myths and highlights its central roles in metabolism, redox balance, and metabolic communication. 👉 doi.org/10.1002/bies.70181
@molecularpepsi #lactate
Cluntun Lab retweeted
Lactate is toxic. Lactate causes fatigue. High lactate is bad.
We hear some version of this all the time.
But how much of it is actually true?
So we wrote a review separating what we know about lactate from what we’ve simply assumed for decades.
Led by our fantastic postdoc Bhavya Blaze! @Bhavya391554759
onlinelibrary.wiley.com/doi/…
#Lactate #Metabolism #ScienceTwitter
Cluntun Lab retweeted
Few scientists know mitochondria better than Jared. Worth listening to.
The new Huberman Lab episode is out: How Mitochondria Control Your Metabolism | Dr. Jared Rutter (@rutterlab)
0:00 Jared Rutter
2:29 Metabolism, Cells; Aging
8:36 Mitochondria, Origin & Cell Complexity
13:07 Sponsors: Joovv & BetterHelp
15:16 Mitochondria Genome, Inheritance
18:18 Mitochondria & Spatial Distribution; Cell-Specific Metabolism
25:59 Nutrient Energy, Hormones, Fat Cells
31:13 Glucose, ATP Conversion, Pyruvate
36:41 Cell Choice: Energy or Growth, Cancer; Virus
46:02 Sponsors: AG1 & Eight Sleep
48:36 Microbiome, Role of Humans
51:44 Molecule Discovery Process, MPC1, MPC2
59:42 Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart
1:07:03 Cell Resource Allocation, MPC, Heart Failure; Disease
1:11:46 Sponsor: Function
1:13:24 Cell Size vs Fuel Balance, Cell Identity & Disease
1:20:43 MPC Discovery, Genetics, Model Systems
1:24:29 Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy
1:31:32 Cancer, Mutations, Metabolism Changes & Warburg Effect
1:36:18 Cancer Challenges & Therapies
1:43:00 Therapy Combinations, Unique Cancer Mutations & Metabolism
1:48:31 Technology to Visualize Metabolism; Disease, Metabolism & Scents
1:56:34 Excess Energy & Mitochondria, Reactive Oxygen Species
2:01:12 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Includes paid partnerships.
Cluntun Lab retweeted
The new Huberman Lab episode is out: How Mitochondria Control Your Metabolism | Dr. Jared Rutter (@rutterlab)
0:00 Jared Rutter
2:29 Metabolism, Cells; Aging
8:36 Mitochondria, Origin & Cell Complexity
13:07 Sponsors: Joovv & BetterHelp
15:16 Mitochondria Genome, Inheritance
18:18 Mitochondria & Spatial Distribution; Cell-Specific Metabolism
25:59 Nutrient Energy, Hormones, Fat Cells
31:13 Glucose, ATP Conversion, Pyruvate
36:41 Cell Choice: Energy or Growth, Cancer; Virus
46:02 Sponsors: AG1 & Eight Sleep
48:36 Microbiome, Role of Humans
51:44 Molecule Discovery Process, MPC1, MPC2
59:42 Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart
1:07:03 Cell Resource Allocation, MPC, Heart Failure; Disease
1:11:46 Sponsor: Function
1:13:24 Cell Size vs Fuel Balance, Cell Identity & Disease
1:20:43 MPC Discovery, Genetics, Model Systems
1:24:29 Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy
1:31:32 Cancer, Mutations, Metabolism Changes & Warburg Effect
1:36:18 Cancer Challenges & Therapies
1:43:00 Therapy Combinations, Unique Cancer Mutations & Metabolism
1:48:31 Technology to Visualize Metabolism; Disease, Metabolism & Scents
1:56:34 Excess Energy & Mitochondria, Reactive Oxygen Species
2:01:12 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Includes paid partnerships.
Cluntun Lab retweeted
Stop what you’re doing and watch this now. I promise you won’t regret it! @hhmi_science @UofUBiochem @RutterLab
The new Huberman Lab episode is out: How Mitochondria Control Your Metabolism | Dr. Jared Rutter (@rutterlab)
0:00 Jared Rutter
2:29 Metabolism, Cells; Aging
8:36 Mitochondria, Origin & Cell Complexity
13:07 Sponsors: Joovv & BetterHelp
15:16 Mitochondria Genome, Inheritance
18:18 Mitochondria & Spatial Distribution; Cell-Specific Metabolism
25:59 Nutrient Energy, Hormones, Fat Cells
31:13 Glucose, ATP Conversion, Pyruvate
36:41 Cell Choice: Energy or Growth, Cancer; Virus
46:02 Sponsors: AG1 & Eight Sleep
48:36 Microbiome, Role of Humans
51:44 Molecule Discovery Process, MPC1, MPC2
59:42 Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart
1:07:03 Cell Resource Allocation, MPC, Heart Failure; Disease
1:11:46 Sponsor: Function
1:13:24 Cell Size vs Fuel Balance, Cell Identity & Disease
1:20:43 MPC Discovery, Genetics, Model Systems
1:24:29 Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy
1:31:32 Cancer, Mutations, Metabolism Changes & Warburg Effect
1:36:18 Cancer Challenges & Therapies
1:43:00 Therapy Combinations, Unique Cancer Mutations & Metabolism
1:48:31 Technology to Visualize Metabolism; Disease, Metabolism & Scents
1:56:34 Excess Energy & Mitochondria, Reactive Oxygen Species
2:01:12 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Includes paid partnerships.
Cluntun Lab retweeted
So happy to see this come out. Keep an eye on this, it’s a game changer!
Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors.
biorxiv.org/content/10.64898…
Cluntun Lab retweeted
Proud milestone for our lab.
This Perspective brings together ideas we've been developing for years into a conceptual framework for understanding lactate biology. I hope it provides a useful lens for thinking about lactate beyond concentration alone.
Huge congratulations to @NichoOffei for leading this work, and thanks to @RutterLab for recommending us for this invited Perspective.
#Metabolism
🚀 First paper from the Cluntun Lab!
Our invited Perspective is now out in @BiochemistryACS.
A framework for understanding lactate biology through subcellular routing and chemical form.
pubs.acs.org/doi/10.1021/acs…
@ACSPublications @RutgersHealth
Congratulations @NichoOffei!
Cluntun Lab retweeted
Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors.
biorxiv.org/content/10.64898…
Cluntun Lab retweeted
Excited to share our new preprint from @RutterLab, identifying a melanosomal tyrosine transporter!
biorxiv.org/content/10.64898…
🚀 First paper from the Cluntun Lab!
Our invited Perspective is now out in @BiochemistryACS.
A framework for understanding lactate biology through subcellular routing and chemical form.
pubs.acs.org/doi/10.1021/acs…
@ACSPublications @RutgersHealth
Congratulations @NichoOffei!