Dave Rhee (@DaveYRhee) header
Dave Rhee (@DaveYRhee) profile picture

Dave Rhee

@DaveYRhee

Dad | Molecular Glues | Proteomics

 Boston, MA
Joined April 2013
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  • Followers146
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Photo by Dave Rhee (@DaveYRhee)Photo by Dave Rhee (@DaveYRhee)
ESPN’s tribute to the one and only Mike Ditka:
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Harvard researcher Joan Brugge says her work has the potential to prevent breast cancer, but she was notified last spring that her federal funding was terminated. “It was just like a gut punch. My knees buckled, and I had to sit down,” she says.
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🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s41467-0…
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EndoMAP.v1 charts the structural landscape of human early endosome complexes nature.com/articles/s41586-0…
EndoMAP.v1 charts the structural landscape of human early endosome complexes

EndoMAP.v1 charts the structural landscape of human early endosome complexes

Nature - A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

nature.com
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Check out our latest study @NatureSMB: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases:#cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains! ❕Publication: nature.com/articles/s41594-0… @SamuelMaiwald @UniLeiden
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#Technology Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt at @scrippsresearch @broadinstitute @harvardmed @MassGeneralNews dlvr.it/TGwBK2
Image from Cell Chemical Biology (@CellChemBiol)
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We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! biorxiv.org/content/10.1101/… 🧵 (1/7)
A multivalent adaptor mechanism drives the nuclear import of proteasomes

A multivalent adaptor mechanism drives the nuclear import of proteasomes

Nuclear protein homeostasis, including the turnover of transcription factors, critically depends on nuclear proteasomes. After each cell division, proteasomes need to be re-imported into the newly...

biorxiv.org
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Dave Rhee retweeted
Rapé Lab (@RapeLab) profile picture
Rapé Lab@RapeLab3 Dec 2024
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. biorxiv.org/content/10.1101/…
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Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.
Nature Methods (@naturemethods) profile pictureNature Methods@naturemethods19 Nov 2024
From @bsadamson and colleagues, a prime editing platform for high-throughput functional interrogation of up to tens of thousands of small genetic variants. nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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Online now! Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt, et al at @scrippsresearch @broadinstitute @harvardmed dlvr.it/TGFYHz
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Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms Awesome collaboration with @sagarchittori . @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G
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6 years of work + Over 2 years in review + 1 extremely talented graduate student @LeonaNease + Amazing collaborators = One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA! nature.com/articles/s43018-0…
Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis

Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis

Nature Cancer - Nease and colleagues demonstrate that the methyltransferase FTSJ1 mediates selenocysteine-specific tRNA methylation of selenoproteins, which protects melanoma cells against...

nature.com
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Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds
Trends in Pharmacological Sciences (@TrendsinPharma) profile pictureTrends in Pharmacological Sciences@TrendsinPharma15 Oct 2024
Chemical proteomic mapping of reversible small molecule binding sites in native systems dlvr.it/TFMRnc
Image from Trends in Pharmacological Sciences (@TrendsinPharma)
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Postdoctoral Position in @businolab Come join us as a #postdoc studying the mechanisms by which the ubiquitin-proteasome system (UPS) controls cancer. jobrxiv.org/job/dr-luca-busi…
Postdoctoral Position in Cancer Biology

Postdoctoral Position in Cancer Biology

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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Open season on FOXA1! Our paper with the Cravatt group is out today in @MolecularCell. Please check out the updated data, including a new discovery that FOXA1 ligands mirror the effects of a nearby prostate cancer mutation. authors.elsevier.com/a/1jxLO… (1/2)
Image from Michael Erb (@Michael_A_Erb)
Image from Michael Erb (@Michael_A_Erb)
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Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF
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Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!! biorxiv.org/content/10.1101/…
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Dave Rhee retweeted
Jimmy Hu (@jimmy_k_hu) profile picture
Jimmy Hu@jimmy_k_hu11 Jun 2024
Excited to share our new paper @PLOSGenetics that reveals how Shh signaling promotes myosin II activity to regulate tooth morphogenesis in mice! doi.org/10.1371/journal.pgen…
Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement

Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement

Author summary During embryonic development, teeth, hair follicles, and glands are examples of ectodermally-derived organs that are formed from slightly thickened epithelial layers, called placodes....

journals.plos.org
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Dave Rhee retweeted
Randy King (@rwkhms) profile picture
Randy King@rwkhms4 Jun 2024
Very pleased to share our latest work on substrate identification of deubiquitylases, led by @VRossio, in collaboration with @PauloLabMS @GygiLab, available @CellChemBiol. Link below is active until July 17. authors.elsevier.com/c/1jA77…
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ZhengLab (@LabZheng) profile picture
ZhengLab@LabZheng4 Jun 2024
Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein biorxiv.org/content/10.1101/…
Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under...

Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under...

The transcription factor BACH1 regulates heme homeostasis and oxidative stress responses and promotes cancer metastasis upon aberrant accumulation. Its stability is controlled by two F-box protein...

biorxiv.org
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