We study the interplay between genetics and epigenetics in shaping cell identity, plasticity, and resilience during development and in disease.
Heidelberg University, Germany
Joined May 2021
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The Dobreva Lab retweeted
Caloric restriction (CR), in many species, extends lifespan. In a new study, CR reduced the accumulation of somatic mutations, but that was not enough to account for change in lifespan. Work in the experimental model.
cell.com/cell/abstract/S0092…
cell.com/cell/abstract/S0092…
The Dobreva Lab retweeted
Our @Nature paper is out!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s41586-0…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
The Dobreva Lab retweeted
New! Online now: Postnatal depression-associated breastmilk extracellular vesicles mediate intergenerational effects on offspring neurodevelopment dlvr.it/TW4y5s
The Dobreva Lab retweeted
Pleased to share our new study on the role of Polycomb in leukemia!
We show that loss of PHF19 promotes stem-like features and reduced treatment response in AML, and identify PHFScore, a new signature to predict patient prognosis.
science.org/doi/10.1126/scia…
The Dobreva Lab retweeted
Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions
cell.com/immunity/fulltext/S… @ImmunityCP
The Dobreva Lab retweeted
A massive study of more than 100,000 people finds surprise connection between ‘good’ body fat and improved mental health
go.nature.com/47kU4tz
The Dobreva Lab retweeted
Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction dlvr.it/TVl8W9
The Dobreva Lab retweeted
Epigenetics Update - HP1α binding creates a local barrier against transcription activation and persists during chromatin decondensation u.epigenome.us/TcbDjse4
Robin Weinmann and @KarstenRippe @DKFZ) in @MolecularCell
#Epigenetics #Chromatin #HP1
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epigenometech.com
The Dobreva Lab retweeted
Space, the final frontier! 🚀 Check out this amazing feat of discovery from my colleague @yuefeng_1 and team. They report the first “Spatial-ATAC-Hi-C”, a method that maps 3D genome organization and chromatin accessibility together while preserving the spatial context of tissues. They have applied this method to brain and tumor samples and revealed cell-specific transcriptional regulation, oncogenic alterations, and clonal heterogeneity within their native tissue microenvironment. A fascinating new window into the spatial organization of the genome! Congratulations Feng and colleagues! @NU_BMG_SQE @NUFeinbergMed @naturemethods @Nature @CellPressNews @ScienceMagazine @theNASciences @theNAMedicine nature.com/articles/s41592-0…
The Dobreva Lab retweeted
Breakthrough Nature paper...
Brain neurons record autoimmune activity and remember it....
nature.com/articles/s41467-0…
The Dobreva Lab retweeted
A massive genomic study has linked mutations in a specific gene to an increased proportion of muscle, decreased levels of belly fat and blood sugar and a reduced risk of conditions including heart disease
go.nature.com/4xrFECL
The Dobreva Lab retweeted
Online Now: METTL3 promotes cell-cycle progression via activation of transcriptional elongation dlvr.it/TTnsY4
The Dobreva Lab retweeted
A new study in Science provides a comprehensive atlas of DNA methylation and 3D genome architecture across human cell types.
Learn more: scim.ag/4x5Y0t0
The Dobreva Lab retweeted
Excited to see our work now published science.org/doi/10.1126/scie…!
Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.
The Dobreva Lab retweeted
Sichuan University scientists develop a biomimetic coating with dynamic stiffness. The coating incorporates #ECM-mimetic components and exhibits tunable stiffness that dynamically decreases in response to microenvironmental stimuli. bit.ly/4wxJcTY
It exhibits stage-specific properties: initially suppressing acute thrombosis and directing cell adhesion; then facilitating a confluent, functional #endothelial monolayer.
#OpenAccess in @ScienceAdvances. 🔓
The Dobreva Lab retweeted
Epigenetics Update - Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor u.epigenome.us/GnuUsdpy
Katherine S. Pollard and @benoitbruneau (@GladstoneInst) in Science
#Epigenetics #Chromatin
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epigenometech.com
The Dobreva Lab retweeted
Does aging always reduce the regenerative capacity of blood vessels? #NO!
Proud to share our latest paper characterizing endothelial proliferation across organs, sex, and aging, discovering unexpected tissue-specific patterns of vascular renewal. rdcu.be/fwvQ6
The Dobreva Lab retweeted
New online! The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing dlvr.it/TTgXwF
