Interested in the complexity of gene expression in Archaea? We have three open postdoc positions focussing on the coupling of transcription and translation using functional genomics, structural biology and molecular biology in Finn Werner's lab at UCL. Links below!
Functional genomics focussed:
ucl.ac.uk/work-at-ucl/search…
And finally the molecular biology focussed role:
ucl.ac.uk/work-at-ucl/search…
Fabian Blombach retweeted
We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg
Exciting to see this! Once considered the only transcription co-activator/regulator conserved between eukaryotes and archaea, it turns out Mbf1 does actually do something entirely different, sorting out ribosome collisions, at least in eukaryotes.
Online Now: Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes dlvr.it/TGGX7c
Fabian Blombach retweeted
We're recruiting a postdoc! Project focused on the molecular and evolutionary biology underpinning antibiotic tolerance. Come join us
@Dunn_School
@UniofOxford
See here for details and to apply: my.corehr.com/pls/uoxrecruit…
Fabian Blombach retweeted
I am very pleased to share our recent study on prokaryotic histone structure and diversity nature.com/articles/s41467-0… Great work by PhD student @SammyBoterhammy. With @aimeelboyle, @Vikram_Alva, Birte Hernandez Alvarez, Yimin Hu, @MPI_Bio, @LeidenScience
Fabian Blombach retweeted
Happy to share our new paper on the characterization of MSTV1, an archaeal virus infecting Methanobrevibacter smithii, the dominant archaeon in the human gut. This was a beautiful collaboration between
@mkrupovic and @SGribaldo labs. 👇🧵nature.com/articles/s41467-0…
Our review on the chromatin transcription relationship in archaea is out: doi.org/10.1111/mmi.15302. ChIP-exo profiles show how chromatin protein Cren7 contributes to the formation of chromatin-free regions around promoters in archaea lacking histones first seen by @georgimarinov.
Fabian Blombach retweeted
Nice to see our manuscript on bacterial histone HBb from Bdellovibrio online:
academic.oup.com/nar/advance…
Different from eukaryotic/archaeal histones, HBb binds and bends DNA as dimer. With Birte Hernandez Alvarez,
@Vikram_Alva
, Yimin Hu,
@SammyBoterhammy
,
@MPI_Bio
,
@LeidenScience
Fabian Blombach retweeted
I never imagined that there would be a paper from my lab titled "The structural basis of ..." but first author @2Magdalena1 and the very collaborative archaeal RNA polymerase made it work 😀. Read it here: academic.oup.com/nar/article…. Thank you also to our partners @lab_engel 🤝!
Happy new year and happy new pre-print biorxiv.org/content/10.1101/… with cryo-EM structures of the archaeal RNA polymerase in its apo state and during elongation w/ and w/o Spt4/5 featuring some distinct archaeal features. #Archaea #cryoEM #transcription Some key findings 🧵
Fabian Blombach retweeted
Please RT: Are you excited about mycobacteria and vitamin B12 metabolism? Do you think you could like working in London? Here's an amazing opportunity for an RA (or PDRA) position at @LSHTM @LSHTM_TB. jobs.lshtm.ac.uk/ITD-DIB-202…
Fabian Blombach retweeted
Our story on tracking the in vivo NusG whereabouts is on @MolecularCell! NusG rarely walks alone, enjoys 30S company, works out on anti-terminating and TT-coupling. True saga by brilliant @HAFEZELSAYYED, super support by
@ojp25 @M_Stracy and Max Gottesman! sciencedirect.com/science/ar…
Fabian Blombach retweeted
I'm happy to present our preprint on mapping chromatin structure in bacteria that have histone-based chromatin:
biorxiv.org/content/10.1101/…
Fabian Blombach retweeted
Now online our studies on the role of the Bdellovibrio bacteriovorus bacterial histone in chromatin organization biorxiv.org/content/10.1101/…
Great collaboration between @Vikram_Alva, Birte Hernandez and @DameLab spearheaded by Yimin Hu and @SammyBoterhammy. @MPIBio @LeidenScienceEN
Our paper on a DNA-bridging histone variant from archaea is out! Great collaboration with Remus Dame lab!! When AF2 predictions and biochemical data support a tetramer, but the crystal structure shows a dimer conformation ... nature.com/articles/s42003-0…
@DameLab @SammyBoterhammy
Fabian Blombach retweeted
🔥Heat shock response in #Sulfolobus🔥
👉In this new #mbio paper we combine omics-experiments to shed light on underlying regulatory mechanisms!
It was a great collaboration between @MicrVub, @SfcLab, @DinaGrohmann, @FelixGrunberger,...!
journals.asm.org/doi/full/10… @fwo @VUBrussel
Fabian Blombach retweeted
Now online Mandy Erkelens experimental studies on archaeal histone binding at a high-affinity sequence. She found that tetramer binding at the high-affinity sequence does not facilitate nucleation of hypernucleosome formation. frontiersin.org/articles/10.…
Our in-depth study of the CRISPR array-specific chromatin protein Cbp1 is now on biorxiv. We show that Cbp1 recruits the chromatin protein Cren7 to CRISPR spacers favouring transcription from the leader promoter over spacer-internal cryptic promoters...
biorxiv.org/content/10.1101/…
