@JABLab3

Jen A-Brett MD PhD ATSF | 🫁 transplant & critical care | mechanisms of #chronic airway disease | cytokines and extracellular vesicles | @CSCTR_org President

 St Louis, MO
sites.wustl.edu/jablab
Joined August 2018
  • Tweets1.1K
  • Following786
  • Followers532
205Media
Congrats to @DuttSohini on her first publication in the lab! Stay tuned for her exciting work, much more to come! doi.org/10.1016/j.healun.202…
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Anyone interested in a visit to 207 High Street, Jefferson City MO around 10am tomorrow?
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I mean, who doesn’t think AP-1 is a central player? We agree 😁
Thomas Vierbuchen@TommyVierbuchen
Mar 26
Apparently it's AP-1 controls cellular memory week. Congrats @chris_cowley14 ! I guess I convinced you AP-1 is so interesting that you never need to work on anything else again... science.org/doi/10.1126/scie…

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory

Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understo...

science.org
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AP-1 TFs control everything, example #312: nature.com/articles/d41586-0… nature.com/articles/s41586-0…

Remembrance of inflammations past

Nature - Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation.

nature.com
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Jen A-Brett retweeted
EXOKĒRYX@exokeryx
Mar 19
With just a few minutes of hands-on set-up, #DemeterEVPrep's hands-off, automated workflow isolates #EVs from up to 8 samples simultaneously. Visit us at @SelectBio's Next-Gen Instruments & Tools Driving EV Research 2026 to learn how Demeter EVPrep can speed your discovery. 🔗👇
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Please join me and @Mkg_Lehmann for a great session on #extracellularvesicles at American Thoracic Society #ATS2026 MTE4 details below: “Small but Mighty – Extracellular Vesicles in Lung Health and Disease.” Extracellular vesicles (EVs) are emerging as key mediators of cell–cell communication in the lung. They enable long-range signaling between structural, immune, and even microbial cells and may contribute to organ–organ crosstalk. At the same time, their precise mechanistic roles in chronic lung diseases remain incompletely understood. MTE EVs In this session, we will discuss how EVs contribute to diseases such as IPF, COPD, and COVID-19, and explore methodological aspects including EV isolation strategies and multi-omic approaches for their characterization. MTE EVs 📅 Sunday, May 17, 2026 ⏰ 10:45 – 11:45 AM (EDT) 📍 ATS International Conference More information and registration: 🔗 lnkd.in/dk8nfgcF #ATS2026 #ExtracellularVesicles #LungResearch #COPD #IPF #CellCommunication #EVs @Vesiculab @exokeryx

LinkedIn

This link will take you to a page that’s not on LinkedIn

lnkd.in
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ISEV members and EV researchers I’d appreciate your support in the Members at Large elections! Open until 3/22.
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Abstract deadline is today!!! Join @CSCTR_org @AFMResearch for a fantastic program! csctr.org/annual-meeting/202…
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Minus the ‘and providers’ yes, you are correct.
Mark Cuban
@mcuban
24 Dec 2025
If we fined insurers and providers $100 every time they over-billed, incorrectly denied care or misrepresented any amount of patient out of pocket, we could pay of the national debt They play on the fear and information asymmetry that exists in healthcare Break them up. Make them divest non insurance companies. And when we are done with the insurance companies , we go to the hospitals and then to the pharma wholesalers. Break em up. Make the markets efficient again.
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Jen A-Brett retweeted
Science News@SciencNews
Jan 5
How to write an excellent Review article #PhD #phdlife #postdoc #Science #academia
Science News@SciencNews
Jan 4
How to Write Your First Research Paper. #phdlife #PhD #academic #academictwitter #Science #research
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Jen A-Brett retweeted
Science News@SciencNews
Jan 6
How to Be a Graduate Advisee
Science News@SciencNews
Jan 4
How to Pick a Graduate Advisor #PhD #Science #academia #phdlife
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A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new Science study. The findings provide a pathway toward targeted therapeutic strategies. Learn more in a new #SciencePerspective: scim.ag/4j8UAA6
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Spermidine deficiency induces BNIP3/LC3B-mediated mitophagy in the salivary glands of accelerated aging mice sciencedirect.com/science/ar…
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Jen A-Brett retweeted
Dr. Dominic Ng
@DrDominicNg
Jan 2
New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵
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Organ-specific proteomic aging clocks predict disease and longevity across diverse populations nature.com/articles/s43587-0…
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Is fibroblast proliferation important in pulmonary fibrosis? Finally an answer - great paper by the super team of Christopher Molina,Tatsuya Tsukui, and Dean Sheppard #זScienceMatters #CureIPF jci.org/articles/view/191826
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Jen A-Brett retweeted
Lior Pachter@lpachter
22 Nov 2025
Academic flexes that I dislike: 1/🧵
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Let’s be data driven! Supported access to professional coaching should be a standard part of every contract 😁
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Thanks for the shout out!
WashU Medicine Department of Medicine@WashUDeptMed
14 Oct 2025
The @JABLab3 led by Jen Alexander-Brett, MD, PhD, @WashUMedPCCM analyzed COPD biospecimens released from cells into the airways. Findings help uncover cellular processes that drive chronic inflammation, tissue damage, and poor lung function. Learn more> internalmedicine.wustl.edu/b…
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🌎 Today is #WorldAlzheimersDay! Make a gift in honor of the 55 million people worldwide living with Alzheimer’s or another dementia and have DOUBLE the impact on accelerating research and helping provide vital care and support: bit.ly/4pDc2iY. #ENDALZ
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